A5047198368- Viral gastroenteritis research and epidemiology
- Salmonella and Campylobacter epidemiology
- Trypanosoma species research and implications
- Parasites and Host Interactions
- Vibrio bacteria research studies
- Respiratory viral infections research
- Pneumonia and Respiratory Infections
- Parasitic Diseases Research and Treatment
- Mosquito-borne diseases and control
- Child Nutrition and Water Access
- Influenza Virus Research Studies
- COVID-19 epidemiological studies
- Neonatal Respiratory Health Research
- Insect symbiosis and bacterial influences
- Health Systems, Economic Evaluations, Quality of Life
- Adolescent and Pediatric Healthcare
- Vector-Borne Animal Diseases
- Hepatitis Viruses Studies and Epidemiology
- Ethics and Legal Issues in Pediatric Healthcare
- Sleep and related disorders
- Chronic Disease Management Strategies
- Clostridium difficile and Clostridium perfringens research
- Meta-analysis and systematic reviews
- Animal Virus Infections Studies
- Parasitic infections in humans and animals
Swiss Tropical and Public Health Institute
2020-2025
University of Basel
2020-2025
Swiss School of Public Health
2024
University of Antwerp
2018-2023
Yale University
2014-2022
University of Chicago
2012-2014
Upcoming vaccination efforts against typhoid fever require an assessment of the baseline burden disease in countries at risk. There are no incidence data from most low- and middle-income (LMICs), so model-based estimates offer insights for decision-makers absence readily available data.We developed a mixed-effects model fit to 32 population-based studies 22 locations 14 countries. We tested contribution economic environmental indices predicting using stochastic search variable selection...
Abstract Background Respiratory syncytial virus (RSV) frequently causes acute lower respiratory infection in children under 5, representing a high burden Gavi-eligible countries (mostly low-income and lower-middle-income). Since multiple RSV interventions, including vaccines monoclonal antibody (mAb) candidates, are development, we aim to evaluate the key drivers of cost-effectiveness maternal vaccination infant mAb for 72 Gavi countries. Methods A static Multi-Country Model Application...
Multidrug resistance and fluoroquinolone non-susceptibility (FQNS) are major concerns for the epidemiology treatment of typhoid fever. The 2018 prequalification first conjugate vaccine (TCV) by WHO provides an opportunity to limit transmission burden antimicrobial-resistant fever.We combined output from mathematical models with estimates antimicrobial meta-analyses predict fever across 73 lower-income countries eligible support Gavi, Vaccine Alliance. We considered FQNS multidrug separately....
BackgroundTyphoid fever is a major cause of morbidity and mortality in low-income middle-income countries. In 2017, WHO recommended the programmatic use typhoid Vi-conjugate vaccine (TCV) endemic settings, Gavi, The Vaccine Alliance, has pledged support for introduction these Country-level health economic evaluations are now needed to inform decision-making.MethodsIn this modelling study, we compared four strategies: no vaccination, routine immunisation at 9 months, months with catch-up...
Abstract Background In recent years, a programme of vector control, screening and treatment gambiense human African trypanosomiasis (gHAT) infections led to rapid decline in cases the Mandoul focus Chad. To represent biology transmission between humans tsetse, we previously developed mechanistic model, fitted data 2000 2013 which suggested that was interrupted by 2015. The present study outlines refinements model to: (1) Assess whether elimination has already been achieved despite low-level...
Abstract Background Respiratory syncytial virus (RSV) causes a substantial burden of acute lower respiratory infection in children under 5 years, particularly low- and middle-income countries (LMICs). Maternal vaccine (MV) next-generation monoclonal antibody (mAb) candidates have been shown to reduce RSV disease infants phase 3 clinical trials. The cost-effectiveness these biologics has estimated using data from global meta-analyses, but are sensitive the detailed age breakdown paediatric...
Typhoid fever remains endemic in low- and middle-income countries. Programmatic use of existing vaccines is limited, but upcoming typhoid conjugate (TCVs) could warrant wider use. We evaluated the cost-effectiveness five TCV delivery strategies three urban areas (Delhi Kolkata, India Nairobi, Kenya) two rural settings (Lwak, Kenya Dong Thap, Vietnam) with varying incidence. routine infant vaccination without catch-up campaigns among older individuals. used a dynamic model transmission to...
Introduction Tuberculosis (TB) remains a significant public health challenge in many African communities, where underreporting and underdiagnosis are prevalent due to barriers accessing care inadequate diagnostic tools. This is particularly concerning hard-to-reach areas with high burden of TB/HIV co-infection, missed or delayed diagnoses exacerbate disease transmission, increase mortality, lead severe economic consequences. To address these challenges, it crucial evaluate innovative,...
A novel typhoid conjugate vaccine (TCV) presentation, the microarray patch (MAP), is in early-stage development and could potentially help to increase coverage hard-to-reach populations beyond what being achieved with current TCV a vial presentation administered needle syringe (TCV-N&S). However, TCV-MAPs may come at higher price per dose than TCV-N&S. Our analysis evaluated potential cost-effectiveness of alongside TCV-N&S compared alone. global extended analysis, taking health care...
Gambiense human African trypanosomiasis (gHAT) is marked for elimination of transmission by 2030, but the disease persists in several low-income countries. We couple and health outcomes models to examine cost-effectiveness four gHAT strategies five settings - spanning low- high-risk Democratic Republic Congo. Alongside passive screening fixed facilities, include active at average or intensified coverage levels, alone with vector control a scale-back algorithm when no cases are reported three...
Background Planning interventions to respond cholera epidemics requires an understanding of the major transmission routes. Interrupting short-cycle (household, foodborne) may require different approaches as compared long-cycle (environmentally-mediated/waterborne) transmission. However, differentiating relative contribution short- and routes has remained difficult, most outbreak control efforts focus on interrupting Here we use high-resolution epidemiological municipal infrastructure data...
Introduction of Vibrio cholerae to Haiti during the deployment United Nations (UN) peacekeepers in 2010 resulted one largest cholera epidemics modern era. Following outbreak, a UN-commissioned independent panel recommended three pre-deployment intervention strategies minimize risk introduction future peacekeeping operations: screening for V. carriage, administering prophylactic antimicrobial chemotherapies, or immunizing with oral vaccines. However, uncertainty regarding effectiveness these...
Interventions to protect young infants against respiratory syncytial virus (RSV) are in advanced phases of development and expected be available the foreseeable future. Gavi, Vaccine Alliance, included maternal vaccines infant monoclonal antibodies for RSV as part 2018 vaccine investment strategy (VIS) decided support these products subject licensure, World Health Organization prequalification, Strategic Advisory Group Experts recommendation, meeting financial assumptions used basis case....
Abstract Gambiense human African trypanosomiasis (gHAT) is marked for elimination of transmission (EoT) by 2030. We examined the cost-effectiveness (CE) EoT in Democratic Republic Congo, which has highest global gHAT burden. In 166 health zones (HZs), we modelled dynamics, outcomes, and economic costs six strategies during 2024-40, including cessation activities after case reporting reduces to zero. Uncertainty CE was assessed within net monetary framework, presented as optimal at a range...
Each year in the United States, influenza causes illness 9.2 to 35.6 million individuals and is responsible for 12,000 56,000 deaths. The U.S. Centers Disease Control Prevention (CDC) tracks activity through a national surveillance network. These data are only available after delay of 1 2 weeks, thus epidemiologists transmission modelers have explored use other sources produce more timely estimates predictions activity. We evaluated whether collected from commercial network diagnostic...
Models are useful to inform policy decisions on typhoid conjugate vaccine (TCV) deployment in endemic settings. However, methodological choices can influence model-predicted outcomes. To provide robust estimates for the potential public health impact of TCVs that account structural model differences, we compared four dynamic and one static mathematical transmission impact. All models were fitted a common dataset age-specific fever cases Kolkata, India. We evaluated three TCV strategies: no...