A5078365368- Trypanosoma species research and implications
- Parasites and Host Interactions
- Mosquito-borne diseases and control
- Evolution and Genetic Dynamics
- Evolutionary Game Theory and Cooperation
- Parasitic Diseases Research and Treatment
- Mathematical and Theoretical Epidemiology and Ecology Models
- Plant and animal studies
- Influenza Virus Research Studies
- Vibrio bacteria research studies
- Insect symbiosis and bacterial influences
- Research on Leishmaniasis Studies
- Industrial Technology and Control Systems
- Advanced Neural Network Applications
- Microplastics and Plastic Pollution
- Adolescent and Pediatric Healthcare
- Animal Disease Management and Epidemiology
- COVID-19 epidemiological studies
- Mechanics and Biomechanics Studies
- Hydraulic and Pneumatic Systems
- Water Quality Monitoring Technologies
University of Warwick
2020-2024
National Tsing Hua University
2015-2022
Institute for Systems Biology
2022
Abstract Background In recent years, a programme of vector control, screening and treatment gambiense human African trypanosomiasis (gHAT) infections led to rapid decline in cases the Mandoul focus Chad. To represent biology transmission between humans tsetse, we previously developed mechanistic model, fitted data 2000 2013 which suggested that was interrupted by 2015. The present study outlines refinements model to: (1) Assess whether elimination has already been achieved despite low-level...
Gambiense human African trypanosomiasis (gHAT) is a virulent disease declining in burden but still endemic West and Central Africa. Although it targeted for elimination of transmission by 2030, there remain numerous questions about the drivers infection how these vary geographically. In this study we focus on Democratic Republic Congo (DRC), which accounted 84% global case 2016, to explore changes across country elucidate factors may have contributed persistence or success interventions...
Gambiense human African trypanosomiasis (gHAT) is marked for elimination of transmission by 2030, but the disease persists in several low-income countries. We couple and health outcomes models to examine cost-effectiveness four gHAT strategies five settings - spanning low- high-risk Democratic Republic Congo. Alongside passive screening fixed facilities, include active at average or intensified coverage levels, alone with vector control a scale-back algorithm when no cases are reported three...
Abstract Gambiense human African trypanosomiasis (sleeping sickness, gHAT) is a disease targeted for elimination of transmission by 2030. While annual new cases are at historical minimum, the likelihood achieving target unknown. We utilised modelling to study impacts four strategies using currently available interventions, including active and passive screening vector control, on burden across 168 endemic health zones in Democratic Republic Congo. Median projected years show only 98 track...
Gambiense human African trypanosomiasis (gHAT) has been targeted for elimination of transmission (EoT) to humans by 2030. Whilst this ambitious goal is rapidly approaching, there remain fundamental questions about the presence non-human animal cycles and their potential role in slowing progress towards, or even preventing, EoT. In study we focus on country with most gHAT disease burden, Democratic Republic Congo (DRC), use mathematical modelling assess whether animals may contribute specific...
Background Human African trypanosomiasis is a parasitic disease caused by trypanosomes among which Trypanosoma brucei gambiense responsible for chronic form (gHAT) in West and Central Africa. Its elimination as public health problem (EPHP) was targeted 2020. Côte d’Ivoire one of the first countries to be validated WHO 2020 this particularly challenging country still reported around hundred cases year early 2000s. This article describes strategies implemented including mathematical model...
Abstract Gambiense human African trypanosomiasis (gHAT) is marked for elimination of transmission (EoT) by 2030. We examined the cost-effectiveness (CE) EoT in Democratic Republic Congo, which has highest global gHAT burden. In 166 health zones (HZs), we modelled dynamics, outcomes, and economic costs six strategies during 2024-40, including cessation activities after case reporting reduces to zero. Uncertainty CE was assessed within net monetary framework, presented as optimal at a range...
Abstract Over the past decade, considerable progress has been made in control, elimination, and eradication of neglected tropical diseases (NTDs). Despite these advances, most NTD programs have recently experienced important setbacks; for example, interventions were some frequently severely impacted by service disruptions due to coronavirus disease 2019 (COVID-19) pandemic. Mathematical modeling can help inform selection meet targets set out road map 2021–2030, such studies should prioritize...
Abstract Background Sleeping sickness ( gambiense human African trypanosomiasis, gHAT) is a vector-borne disease targeted for global elimination of transmission (EoT) by 2030. There are, however, unknowns that have the potential to hinder achievement and measurement this goal. These include asymptomatic gHAT infections (inclusive self-cure or harbour skin-only infections) whether infection in animals can contribute cycle humans. Methods Using modelling, we explore how cryptic (undetected)...
ABSTRACT Gambiense human African trypanosomiasis (sleeping sickness, gHAT) is a disease targeted for elimination of transmission (EOT) by 2030. Despite the number new cases reported annually being at historical minimum, likelihood achieving EOT unknown. We utilised modelling to study impact four strategies comprised currently-available intervention methods including active and passive screening vector control (VC) on across 168 health zones in Democratic Republic Congo. By estimating median...
Abstract Gambiense human African trypanosomiasis (gHAT) is a virulent disease declining in burden but still endemic West and Central Africa. Although it targeted for elimination of transmission by 2030, there remain numerous questions about the drivers infection how these vary geographically. In this study we focus on Democratic Republic Congo (DRC), which accounted 84% global case 2016, to explore changes across country elucidate factors may have contributed persistence or success...
The global health community has earmarked a number of diseases for elimination or eradication, and these goals have often been praised on the premise long-run cost savings. However, decision makers must contend with multitude demands budgets in short medium term, costs per case rise as burden disease falls, rendering such efforts beyond cost-effective use scarce resources. In addition, decisions be made presence substantial uncertainty regarding feasibility eradication efforts. Therefore,...
Background: Gambiense human African trypanosomiasis (gHAT) is marked for elimination of transmission (EOT) by 2030, but the disease persists in several low-income countries. We examine cost-effectiveness four gHAT strategies Democratic Republic Congo (DRC), which has highest burden gHAT.Methods: compared against coupling a model with health outcomes five settings – spanning low- to high-risk. Alongside passive surveillance (PS) fixed facilities, included active screening (AS) at average or...
Abstract Gambiense human African trypanosomiasis (gHAT) is marked for elimination of transmission (EOT) by 2030, but the disease persists in several low-income countries. We coupled and health outcomes models to examine cost-effectiveness four gHAT strategies five settings – spanning low- high-risk Democratic Republic Congo. Alongside passive screening (PS) fixed facilities, included active (AS) at average or intensified coverage levels, alone with vector control (VC) a scale-back algorithm...
Marine debris is a problem both for the health of marine environments and human since tiny pieces plastic called "microplastics" resulting from decomposition over time are entering food chain at any levels. For detection removal, autonomous underwater vehicles (AUVs) potential solution. In this letter, we focus on efficiency AUV vision real-time low-light object detection. First, improved class state-of-the-art detectors, namely EfficientDets, by 1.5% AP D0, 2.6% D1, 1.2% D2 1.3% D3 without...
Abstract Sleeping sickness (gambiense human African trypanosomiasis, gHAT) is a vector-borne disease targeted for global elimination of transmission (EoT) by 2030. There are, however, unknowns that have the potential to hinder achievement and measurement this goal. These include asymptomatic gHAT infections (inclusive self-cure or harbour skin-only infections) whether infection in animals can contribute cycle humans. Using modelling we explore how cryptic (undetected) impacts monitoring...
Abstract Background Human African trypanosomiasis is a parasitic disease caused by trypanosomes among which Trypanosoma brucei gambiense responsible for chronic form (gHAT) in West and Central Africa. Its elimination as public health problem (EPHP) being achieved. Côte d’Ivoire was one of the first countries to be validated WHO 2020 this particularly challenging country still reported around hundred cases year early 2000s. This article describes strategies implemented including mathematical...
Gambiense human African trypanosomiasis (gHAT) is a deadly vector-borne, neglected tropical disease found in West and Central Africa targeted for elimination of transmission (EoT) by 2030. The recent pandemic has illustrated how it can be important to quantify the impact that unplanned disruption programme activities may have achieving EoT. We used previously developed model gHAT fitted data from Democratic Republic Congo, country with highest global case burden, explore interruptions...
Human African trypanosomiasis, caused by the gambiense subspecies of Trypanosoma brucei (gHAT), is a deadly parasitic disease transmitted tsetse. Partners worldwide have stepped up efforts to eliminate disease, and Chadian government has focused on previously high-prevalence setting Mandoul. In this study, we evaluate economic efficiency intensified strategy that was put in place 2014 aimed at interrupting transmission gHAT, make recommendations best way forward based both epidemiological...
The global health community has earmarked a number of diseases for elimination or eradication, and these goals have often been praised on the premise long-run cost-savings. However, decision-makers must contend with multitude demands budgets in short- medium-term, costs-per-case rise as burden disease falls, rendering such efforts beyond cost-effective use scarce resources. In addition, decisions be made presence substantial uncertainty regarding feasibility costs eradication efforts....
Evolutionary dynamics is captured by replicator equations when populations are well mixed. However, in realistic ecosystems, competitions often occur between neighbors and the spatial structure of system significant importance. In most evolutionary algorithms, local death/birth processes relies on effective fitness: a global knowledge whole ecosystem. To make game theory logically consistent, it desirable to introduce an algorithm where only information necessary. Here we resolve challenge...
Dynamically substructured system (DSS) technique is increasing recognized in the testing field. A DSS method decomposes an entire into several substructures, which are tested numerically or physically, but run as a whole like original system. Thus, advantages of include flexibility, space-saving, and cost-reduction. In test, actuators produce unexpected disturbance, when transferring mechanical power control signals between numerical physical substructures. The ill-conditioned substructure...
We investigate the error threshold for emergence of quasispecies in Eigen model. By mapping to an effective Hamiltonian ruled by "imaginary-time" Schr\"odinger equation, a variational ansatz is proposed and applied calculate various quantities associated with quasispecies. The gives correct predictions survival population wild-type sequence also reveals unexpected universal scaling behaviors near threshold. check validity numerical methods find excellent agreement. Though not yet fully...
Abstract Human African trypanosomiasis, caused by the gambiense subspecies of Trypanosoma brucei (gHAT), is a deadly parasitic disease transmitted tsetse. Partners from around world have stepped up efforts to eliminate disease, and Chadian government had particular focus on previously high-prevalence setting Mandoul. In this study, we evaluate economic efficiency intensified strategies that were put in place 2014 aimed at interrupting transmission gHAT, make recommendations best way forward...