Luc E. Coffeng
A5080298922- Parasites and Host Interactions
- Parasitic Diseases Research and Treatment
- Parasite Biology and Host Interactions
- Helminth infection and control
- Global Maternal and Child Health
- Insects and Parasite Interactions
- Research on Leishmaniasis Studies
- Child Nutrition and Water Access
- Mosquito-borne diseases and control
- COVID-19 epidemiological studies
- Malaria Research and Control
- Trypanosoma species research and implications
- Insect symbiosis and bacterial influences
- Health disparities and outcomes
- Zoonotic diseases and public health
- Dermatological diseases and infestations
- Global Health Care Issues
- Data-Driven Disease Surveillance
- Viral Infections and Vectors
- Mental Health Research Topics
- COVID-19 Digital Contact Tracing
- Parasitic Infections and Diagnostics
- Vaccine Coverage and Hesitancy
- Infant Nutrition and Health
- Leprosy Research and Treatment
Erasmus University Rotterdam
2012-2024
Erasmus MC
2015-2024
University of Oxford
2022
Swiss Tropical and Public Health Institute
2022
University of Basel
2022
Imperial College London
2022
Radboud University Nijmegen
2022
Radboud University Medical Center
2022
University of Warwick
2022
ORCID
2020-2021
Asociación entre disminución de la sensibilidad parasitaria in vitro y respuesta terapéutica en pacientes con Leishmaniasis cutánea tratados el centro dermatológico Federico Lleras Acosta ciudad Bogotá
Disability secondary to skin conditions is substantial worldwide. The Global Burden of Disease Study 2013 includes estimates global morbidity and mortality due diseases.To measure the burden diseases worldwide.For nonfatal estimates, data were found by literature search using PubMed Google Scholar in English Spanish for years 1980 through accessing administrative on hospital inpatient outpatient episodes. Data fatal based vital registration verbal autopsy data.Skin disease extracted from...
The literature focuses on mortality among children younger than 5 years. Comparable information nonfatal health outcomes these and the fatal burden of diseases injuries older adolescents is scarce.
The African Programme for Onchocerciasis Control (APOC) was created in 1995 to establish community-directed treatment with ivermectin (CDTi) order control onchocerciasis as a public health problem 20 countries that had 80 % of the global disease burden. When research showed CDTi may ultimately eliminate infection, APOC given 2008 additional objective determine when and where can be safely stopped. We report results epidemiological evaluations undertaken from 2014 assess progress towards...
The World Health Organization (WHO) has set ambitious targets for the elimination of onchocerciasis by 2020-2025 through mass ivermectin treatment. Two different mathematical models have assessed feasibility reaching this goal settings and treatment scenarios, namely individual-based microsimulation model ONCHOSIM population-based deterministic EPIONCHO. In study, we harmonize some crucial assumptions compare predictions on common outputs.Using a range initial endemicity levels compared with...
The new Global Burden of Disease Study 2013 has identified some key trends in the major neglected tropical diseases, many with public health and policy implications.The (GBD) is a landmark initiative that systematically quantifies prevalence, morbidity, mortality for hundreds injuries, risk factors global importance.For diseases (NTDs), GBD 2010 confirmed high disease burden 17 NTDs prioritized by World Health Organization (WHO) as well selected conditions also recognized PLOS Neglected...
Background Onchocerciasis causes a considerable disease burden in Africa, mainly through skin and eye disease. Since 1995, the African Programme for Control (APOC) has coordinated annual mass treatment with ivermectin 16 countries. In this study, we estimate health impact of APOC associated costs from program perspective up to 2010 provide expected trends 2015. Methods Findings With data on pre-control prevalence infection population coverage treatment, simulated infection, blindness, visual...
Abstract Due to the COVID-19 pandemic, many key neglected tropical disease (NTD) activities have been postponed. This hindrance comes at a time when NTDs are progressing towards their ambitious goals for 2030. Mathematical modelling on several NTDs, namely gambiense sleeping sickness, lymphatic filariasis, onchocerciasis, schistosomiasis, soil-transmitted helminthiases (STH), trachoma, and visceral leishmaniasis, shows that impact of this disruption will vary across diseases. Programs face...
Considerable efforts have been made to better understand the effectiveness of large-scale preventive chemotherapy therapy for control morbidity caused by infection with soil-transmitted helminths (STHs): Ascaris lumbricoides, Trichuris trichiura, and 2 hookworm species, Necator americanus Ancylostoma duodenale. Current World Health Organization (WHO) guidelines STH include mass drug administration (MDA) programs based on prevalence measurements, aiming at reducing in pre-school-aged children...
Abstract Control of soil-transmitted helminths relies heavily on regular large-scale deworming high-risk groups (e.g., children) with benzimidazole derivatives. Although drug resistance has not yet been documented in human helminths, cattle and sheep led to widespread veterinary helminths. Here we predict the population dynamics helminth infections during 20 years preventive chemotherapy, using an individual-based model. With current chemotherapy strategy mainly targeting children schools,...
Quantitative analysis and mathematical models are useful tools in informing strategies to control or eliminate disease. Currently, there is an urgent need develop these inform policy achieve the 2020 goals for neglected tropical diseases (NTDs). In this paper we give overview of a collection novel model-based analyses which aim address key questions on dynamics transmission nine NTDs: Chagas disease, visceral leishmaniasis, human African trypanosomiasis, leprosy, soil-transmitted helminths,...
Background The initial endemicity (pre-control prevalence) of onchocerciasis has been shown to be an important determinant the feasibility elimination by mass ivermectin distribution. We present first geostatistical map microfilarial prevalence in former Onchocerciasis Control Programme West Africa (OCP) before commencement antivectorial and antiparasitic interventions. Methods Findings Pre-control data from 737 villages across 11 constituent countries OCP epidemiological database were used...
Malaria elimination strategies require a thorough understanding of parasite transmission from human to mosquito. A clinical model induce gametocytes understand their dynamics and evaluate transmission-blocking interventions (TBI) is currently unavailable. Here, we explore the use well-established Controlled Human Infection (CHMI) gametocyte carriage with different antimalarial drug regimens.
Scabies is a neglected tropical disease (NTD) that causes significant health burden, particularly in disadvantaged communities and where there overcrowding. There emerging evidence ivermectin-based mass drug administration (MDA) can reduce the prevalence of scabies some settings, but remains limited, are no formal guidelines to inform control efforts. An informal World Health Organization (WHO) consultation was organized find agreement on strategies for global control. The resulted framework...
The estimation of parameters and model structure for informing infectious disease response has become a focal point the recent pandemic. However, it also highlighted plethora challenges remaining in fast robust extraction information using data models to help inform policy. In this paper, we identify discuss four broad paradigm relating modelling, namely Uncertainty Quantification framework, estimation, model-based inference prediction, expert judgement. We postulate priorities methodology...
The African Programme for Onchocerciasis Control (APOC) is currently shifting its focus from morbidity control to elimination of infection. To enhance the likelihood and speed up achievement, programs may consider increase frequency ivermectin mass treatment annual 6-monthly or even higher. In a computer simulation study, we examined potential impact increasing different settings. With ONCHOSIM model, simulated 92,610 scenarios pertaining assumptions about transmission conditions, history...
Globally, hookworms infect 440 million people in developing countries. Especially children and women of childbearing age are at risk anaemia as a result infection. To control hookworm infection disease (i.e. reduce the prevalence medium heavy to <1 %), World Health Organization has set target provide annual or semi-annual preventive chemotherapy (PC) with albendazole (ALB) mebendazole (MEB) least 75 % all endemic areas by 2020. Here, we predict feasibility achieving infection, based on...