A5103155676- Parasitic Diseases Research and Treatment
- Parasite Biology and Host Interactions
- Parasites and Host Interactions
- Insects and Parasite Interactions
- Insect symbiosis and bacterial influences
- Helminth infection and control
- Mosquito-borne diseases and control
- Dermatological diseases and infestations
- Herpesvirus Infections and Treatments
- Animal Virus Infections Studies
- Planarian Biology and Electrostimulation
- Lymphatic System and Diseases
- Virus-based gene therapy research
- Nematode management and characterization studies
- Occupational exposure and asthma
- Mast cells and histamine
- Vector-Borne Animal Diseases
- Microbial infections and disease research
- Insect and Arachnid Ecology and Behavior
- Indoor Air Quality and Microbial Exposure
- Genetic and phenotypic traits in livestock
- Virology and Viral Diseases
- Body Image and Dysmorphia Studies
- Pharmacological Effects and Toxicity Studies
- Parasitic infections in humans and animals
The Task Force for Global Health
2017-2025
Tula Foundation
2025
Hakai Institute
2025
Michigan State University
2010-2019
Michigan United
2014-2018
Liverpool School of Tropical Medicine
2015-2017
Western Michigan University
2002-2015
University of London
1980-2007
Imaging Center
2002
International Centre for Reproductive Health Kenya
1999
Implementation of an ivermectin-based community treatment strategy for the elimination onchocerciasis or lymphatic filariasis has been delayed in Central Africa because occurrence serious adverse events, including death, persons with high levels circulating Loa loa microfilariae. The LoaScope, a field-friendly diagnostic tool to quantify L. microfilariae peripheral blood, enables rapid, point-of-care identification at risk events.A test-and-not-treat was used approach ivermectin Okola health...
Mass treatment with ivermectin for onchocerciasis was stopped in 2012 Abu Hamed, an isolated focus on the River Nile northern Sudan. A 3-year posttreatment surveillance (PTS) ensued, at end of which evaluation conducted 2015 following current World Health Organization guidelines verification elimination. Vector black flies were collected from sentinel breeding sites and finger-prick bloodspots children ≤ 10 years age resident 35 communities within focus. Polymerase chain reaction (PCR)...
Ivermectin (IVM) is a broad-spectrum anthelmintic used in filariasis control programs. By binding to nematode glutamate-gated chloride channels (GluCls), IVM disrupts neurotransmission processes regulated by GluCl activity. treatment of filarial infections characterized an initial dramatic drop the levels circulating microfilariae, followed long-term suppression their production, but drug has little direct effect on microfilariae culture at pharmacologically relevant concentrations. We...
Filarial nematodes cause chronic and profoundly debilitating diseases in both humans animals. Applications of novel technology are providing unprecedented opportunities to improve diagnosis our understanding the molecular basis for host-parasite interactions. As a first step, we investigated presence circulating miRNAs released by filarial into host bloodstream. miRNA deep-sequencing combined with bioinformatics revealed over 200 mature sequences potential nematode origin Dirofilaria...
Abu Hamed, Sudan, the northernmost location of onchocerciasis in world, began community-directed treatment with ivermectin (CDTI) 1998, annual treatments enhanced to semiannual 2007. We assessed status parasite transmission 2011 entomologically, parasitologically, and serologically. O-150 pool screening showed no DNA 17,537 black flies collected (95% confidence interval upper limit [95% CI UL] = 0.023). Skin microfilariae, nodules, signs skin disease were absent 536 individuals seven local...
Background. Ivermectin (IVM) has been the drug of choice for treatment onchocerciasis. However, there have reports persistent microfilaridermia in individuals from an endemic area Ghana after many rounds IVM, raising concerns suboptimal response or even emergence resistance. Because it is considered risky to continue relying only on IVM combat this phenomenon, we assessed effect targeting Onchocerca volvulus Wolbachia endosymbionts with doxycycline these response. Methods. One hundred...
Scabies is a neglected tropical disease (NTD) that causes significant health burden, particularly in disadvantaged communities and where there overcrowding. There emerging evidence ivermectin-based mass drug administration (MDA) can reduce the prevalence of scabies some settings, but remains limited, are no formal guidelines to inform control efforts. An informal World Health Organization (WHO) consultation was organized find agreement on strategies for global control. The resulted framework...
Background People with disabilities due to neglected tropical diseases (NTDs), such as leprosy and lymphatic filariasis (LF), often encounter situations of stigma discrimination that significantly impact their mental wellbeing. Mental wellbeing services are not available at the peripheral level in NTD-endemic countries, there is a need for services. Basic psychological support persons NTDs (BPS-N) from peers an important potential solution addressing problems. As was no written document...
Large changes in marine CO2 chemistry manifest areas with weakly-buffered seawater where ocean acidification (OA) acts concert natural additions. These settings can exhibit periods of extreme OA the form multiple co-occurring stressors, including calcite undersaturation and low pH. Such conditions were observed northern Strait Georgia, on northeast Pacific coast, spanned a 3-year period. Here, we utilized an 8-year, highly-resolved record partial pressure total dissolved inorganic carbon to...
Journal Article Eosinophil leucocytes in filarial infections Get access C.D. Mackenzie Dept. of Medical Helminthology, London School Hygiene and Tropical Medicine, Keppel Street, WC1E 7HT U.K. Search for other works by this author on: Oxford Academic PubMed Google Scholar Transactions The Royal Society Medicine Hygiene, Volume 74, Issue Supplement, 1980, Pages 51–58, https://doi.org/10.1016/0035-9203(80)90273-4 Published: 01 January 1980
Background Individuals with high intensity of Loa loa are at risk developing serious adverse events (SAEs) post treatment ivermectin. These SAEs have remained unclear and a programmatic impediment to the advancement community directed The pathogenesis these following ivermectin has never been investigated experimentally. Loa/baboon (Papio anubis) model can be used investigate Loa-associated encephalopathy in humans. Methods 12 baboons microfilarial loads > 8,000mf/mL blood were randomised...
Chronic degeneration of articular cartilage and bone in a rabbit model post-traumatic osteoarthrosis has been hypothesized to occur due acute stresses that exceed threshold for injury. In this study, we impacted the patellofemoral joint at low high intensities. High-intensity impacts produced degenerative changes joint, such as softening retropatellar cartilage, measured by indentation, an increase histopathology thickness sub-chondral underlying cartilage. Low-intensity did not cause these...
Abstract Background The characterization of proteins released from filariae is an important step in addressing many the needs diagnosis and treatment these clinically parasites, as well contributing to a clearer understanding their biology. This report describes findings on during vitro cultivation adult Dirofilaria immitis , causative agent canine feline heartworm disease. Differences protein secretion among nematodes vivo may relate ecological niche each parasite pathological changes that...
A test-and-not-treat (TaNT) strategy has been developed to prevent people with high concentrations of circulating Loa loa microfilariae (>20 000 per mL) developing serious adverse events after ivermectin treatment during mass drug administration eliminate onchocerciasis. An important question related cost and programmatic issues is whether annual retesting required for everyone. We therefore aimed investigate changes in L microfilarial densities TaNT campaigns run 18 months apart.In this...
Providing and improving the care of patients suffering from lymphedema remains an essential goal for clinical management populations affected by lymphatic filariasis. Although Essential Package Care (EPC) recommended WHO leads to important positive benefits many these patients, it is continue address challenges that remain both in quantifying effects ensuring optimal care. This report, based on authors’ scientific field experience, focuses impact significance lymphedema, its presentation,...
Abstract The goal of this study was to document the effect blunt‐impact trauma on knee in a small animal model that incorporated known level physical exercise after impact. We hypothesized single blunt impact patellofemoral joint, magnitude comparable with our earlier studies, would result degenerative changes cartilage and subchondral bone patella. Blunt impacts were delivered rabbit joints without producing fracture, biomechanical histological analyses performed joint tissues at various...
Mouse monoclonal antibodies directed against biochemically defined surface antigens of Trichinella spiralis were selected and tested for their ability to destroy parasites in vivo vitro. One these (NIM-M5; IgG1), which recognised a component approximately 64 K molecular weight newborn larvae (NBL), bound this stage (as shown by fluorescence), mediated the adherence rodent eosinophil leucocytes living NBL. Following cell antibody, worms killed. This effect was enhanced fresh normal serum...