A5039639053- Parasitic Diseases Research and Treatment
- Insects and Parasite Interactions
- Parasite Biology and Host Interactions
- Dermatological diseases and infestations
- Parasites and Host Interactions
- Mosquito-borne diseases and control
- Autoimmune Bullous Skin Diseases
- Skin and Cellular Biology Research
- Infectious Diseases and Mycology
- Insect symbiosis and bacterial influences
- Mast cells and histamine
- Mycobacterium research and diagnosis
- Global Maternal and Child Health
- Psoriasis: Treatment and Pathogenesis
- Primate Behavior and Ecology
- Autoimmune and Inflammatory Disorders
- Cytokine Signaling Pathways and Interactions
- Body Contouring and Surgery
- Systemic Sclerosis and Related Diseases
- Vasculitis and related conditions
- Cultural Competency in Health Care
- Skin Diseases and Diabetes
- Dermatologic Treatments and Research
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Dermatological and Skeletal Disorders
Watford General Hospital
2011-2023
West Hertfordshire Hospitals NHS Trust
2017-2023
Liverpool School of Tropical Medicine
2019
St John's Hospital
2017
Derriford Hospital
2012
Torbay Hospital
2012
St Thomas' Hospital
1991-2007
The London College
2002
Imperial College London
1992-1997
Ahmadu Bello University Teaching Hospital
1992-1997
Asociación entre disminución de la sensibilidad parasitaria in vitro y respuesta terapéutica en pacientes con Leishmaniasis cutánea tratados el centro dermatológico Federico Lleras Acosta ciudad Bogotá
The new Global Burden of Disease Study 2013 has identified some key trends in the major neglected tropical diseases, many with public health and policy implications.The (GBD) is a landmark initiative that systematically quantifies prevalence, morbidity, mortality for hundreds injuries, risk factors global importance.For diseases (NTDs), GBD 2010 confirmed high disease burden 17 NTDs prioritized by World Health Organization (WHO) as well selected conditions also recognized PLOS Neglected...
Introduction Onchocerciasis is targeted for elimination mainly with annual community-directed treatment ivermectin (CDTI). High infection levels have been reported in South-West Cameroon, despite ≥15 years of CDTI. The aim this study was to assess factors associated continued onchocerciasis transmission and skin disease. Methods A large-scale cross-sectional conducted 2017 20 communities a loiasis-risk area Cameroon. mixed-methods approach used. Associations between levels, disease adherence...
Although onchocerciasis is one of the most important diseases skin and eye in tropical world, to date there has been no formal consensus regarding description terminology lesions. Furthermore, contribution cutaneous pathology morbidity socio‐economic effects disease largely neglected. We present a clinical classification grading system for recording changes onchocerciasis, propose that this be used as standard method convey information between workers all endemic areas assist local...
Neglected tropical diseases (NTDs) are communicable that occur under conditions of poverty and concentrated almost exclusively in impoverished populations the developing world. NTDs affect more than 1000 million people subtropical countries, costing economies billions dollars every year. Effective control can be achieved with use large-scale delivery single-dose preventive chemotherapy (PC) or intensified disease management (IDM) both, as is case for some such lymphatic filariasis, trachoma,...
Background Onchocerciasis causes a considerable disease burden in Africa, mainly through skin and eye disease. Since 1995, the African Programme for Control (APOC) has coordinated annual mass treatment with ivermectin 16 countries. In this study, we estimate health impact of APOC associated costs from program perspective up to 2010 provide expected trends 2015. Methods Findings With data on pre-control prevalence infection population coverage treatment, simulated infection, blindness, visual...
On 8 June 2022, the World Health Organization (WHO) released pivotal guidance, “Ending neglect to attain Sustainable Development Goals: A strategic framework for integrated control and management of skin-related neglected tropical diseases.” Skin-related diseases, or skin NTDs, comprise a group NTDs that produce signs symptoms on include at least 9 diseases disease groups. Moving away from disease-specific approaches, it is anticipated synergies will be identified building this shared...
An attempt was made to assess the true public-health importance of onchocercal skin disease throughout African region and hence provide an objective basis for rational planning onchocerciasis control in area. The seven collaborative centres that participated study (three Nigeria one each Ghana, Cameroon, Tanzania Uganda) were all areas rainforest or savannah-forest mosaic where blindness is not common. A cross-sectional dermatological survey undertaken at site following a standard protocol....
Summary Clinical and immunopathological studies of three patients with lichen planus pemphigoides (LPP) were carried out to investigate the relationship between LPP bullous pemphigoid (BP) determine whether antigen in is classical BP antigen. usually considered be coexistence BP. The bullae subepidermal indistinguishable from Indirect immunofluorescence demonstrated antibody binding epidermal surface 1 M NaCI-spIit skin mucosae. as tissue distribution mirrored stratified squamous epithelia...
The prospect of eliminating onchocerciasis from Africa by mass treatment with ivermectin has been rejuvenated following recent successes in foci Mali, Nigeria and Senegal. Elimination prospects depend strongly on local transmission conditions therefore pre-control infection levels. Pre-control levels have mapped largely means nodule palpation adult males, a relatively crude method for detecting infection. We investigated how informative prevalence data are estimating the microfilariae (mf)...
Skin-related neglected tropical diseases, or skin NTDs, comprise a group of NTDs that produce signs and symptoms on the skin, includes at least nine diseases disease groups. The World Health Organization launched ‘Ending neglect to attain Sustainable Development Goals: strategic framework for integrated control management skin-related diseases’ in June 2022, which this article summarises sets out way forward including guidance how dermatologists dermatological communities along with public...
Atypical mycobacterial infections of the skin have increased in frequency immunocompromised individuals recent years. Such patients may follow a different clinical pattern from immunocompetent patients, often lacking history preceding trauma and presenting with multiple suppurating subcutaneous nodules. A sporotrichoid spread occur species Mycobacterium kansasii M. marinum but is rare chelonei.
Summary Objectives To assess the long‐term impact of African Programme for Onchocerciasis Control on itching and onchocercal skin disease (OSD). Methods Seven study sites in Cameroon, Sudan, Nigeria Uganda participated. Two cross‐sectional surveys were conducted communities meso‐ hyper‐endemic onchocerciasis before after 5 or 6 years community‐directed treatment with ivermectin (CDTI). Individuals asked about any general health symptoms including underwent full cutaneous examinations....
To evaluate onchocerciasis control activities in the Democratic Republic of Congo (DRC) first 12 years community-directed treatment with ivermectin (CDTI).Data from National Programme for Onchocerciasis (NPO) provided by Task Force (NOTF) through annual reports 21 CDTI projects 2001-2012 were reviewed retrospectively. A hypothetical-inputs-process-outputs-outcomes table was constructed.Community-directed expanded 1968 communities 2001 to 39 100 2012 while number distributors (CDD) and health...
Onchocerciasis is a priority neglected tropical disease targeted for elimination by 2025. The standard strategy to combat onchocerciasis annual Community-Directed Treatment with ivermectin (CDTi). Yet, high prevalence rates and transmission persist following > 12 rounds in South-West Cameroon. Challenges include programme coverage, adherence to, acceptability of an area Loa loa co-endemicity. Loiasis patients harbouring heavy infections are at risk potentially fatal serious adverse events...
Onchocerciasis ("river blindness") can cause severe morbidity, including vision loss and various skin manifestations, is targeted for elimination using ivermectin mass drug administration (MDA). We calculated the number of people with Onchocerca volvulus infection onchocercal eye disease as well disability-adjusted life years (DALYs) lost from 1990 through to 2030 in areas formerly covered by African Programme Control. Per MDA implementation unit, we collated data on pre-control distribution...
Background Onchocerca volvulus infection can result in blindness, itching and skin lesions. Previous research concentrated on blindness. Methods A clinical classification system of the cutaneous changes onchocerciasis was used for first time this study within context an early ivermectin drug trial savanna region Kaduna State, northern Nigeria. Skin examinations were performed 6,790 individuals aged 5+ years endemic communities 1,343 nonendemic communities. Results / Discussion There...
A community-directed treatment with ivermectin (CDTI) for fighting onchocerciasis was started in 2003 the hyperendemic province of Bandundu, Democratic Republic Congo (DRC); such initiative supported by African Programme Onchocerciasis Control (APOC). As APOC stopped at end 2015, there an urgent need to assess sustainability treatment. cross-sectional survey knowledge, attitude and perception conducted determine awareness level local population regarding disease. multi-stage random sampling...