A5068965640- Parasitic Diseases Research and Treatment
- Parasite Biology and Host Interactions
- Parasites and Host Interactions
- Insects and Parasite Interactions
- Mosquito-borne diseases and control
- Agriculture and Rural Development Research
- Vector-Borne Animal Diseases
- Agricultural Systems and Practices
- Agricultural Innovations and Practices
University of Buea
2019-2024
Coral Reef Research Foundation
2020
Introduction Onchocerciasis is targeted for elimination mainly with annual community-directed treatment ivermectin (CDTI). High infection levels have been reported in South-West Cameroon, despite ≥15 years of CDTI. The aim this study was to assess factors associated continued onchocerciasis transmission and skin disease. Methods A large-scale cross-sectional conducted 2017 20 communities a loiasis-risk area Cameroon. mixed-methods approach used. Associations between levels, disease adherence...
Conventional diagnosis of filarial infections is based on morphological identification microfilariae using light microscopy and requires considerable expertise, time-consuming, can be subjective. Loop-mediated isothermal amplification (LAMP) has advantages over or PCR because its operational simplicity, rapidity versatility readout options. LAMP assays represent a major step forward in improved diagnostic tools suitable for low resource settings field applicability. The study goal was to...
Onchocerciasis is a priority neglected tropical disease targeted for elimination by 2025. The standard strategy to combat onchocerciasis annual Community-Directed Treatment with ivermectin (CDTi). Yet, high prevalence rates and transmission persist following > 12 rounds in South-West Cameroon. Challenges include programme coverage, adherence to, acceptability of an area Loa loa co-endemicity. Loiasis patients harbouring heavy infections are at risk potentially fatal serious adverse events...
The diagnosis of onchocerciasis in endemic areas has been demanding given the need to replace invasive skin snip method with a more sensitive and specific rapid point-of-contact tool. Filarial antigen detection tests are better alternative methods diagnosing Onchocercal infections, as they detect infections could be used monitor transmission following mass drug administration. With shift paradigme from control elimination, point- of-contact tool is required support elimination programs. This...
Introduction Mouse models of human filarial infections are not only urgently needed to investigate the biology nematodes and their modulation host’s immunity, but will also provide a platform screen test novel anti-filarial drugs. Recently, murine Loa loa infection have been stablished using immunocompromised mouse strains, whereas Mansonella perstans implemented until now. Methods Therefore, we aim establish experimental M. strains RAG2IL-2Rγ -/- (lack B, T natural killer cells),...
Mansonella perstans infections are widespread in Sub-Saharan Africa and Central South America thus can be considered as the most prevalent parasite of man tropical Africa. In contrast to high prevalence, knowledge about biology this filarial nematode is restricted no effective treatment regimens ivermectin-resistant lacking. An obstacle for research that M. resides body cavities have been only rarely recovered during surgery or autopsy. Therefore, alternative methods like vitro culture...
Background Mansonella perstans is transmitted by Culicoides species and affects hundred millions of inhabitants in about 33 countries sub-Saharan Africa. It known that Mansonellosis due to do not result a clear clinical picture, but down-regulates the immunity patients predisposing them other diseases like tuberculosis, HIV malaria or damping vaccine efficacy. However, research novel drugs against this filarial nematode missing because lack parasite material. Previous studies have developed...
Onchocerciasis control using ivermectin alone has been achieved in some endemic savannah zones of Africa. In the forest regions, co-endemicity with Loa loa led to severe adverse events (SAEs) resulting poor adherence community members mass drug administration (MDA). This may jeopardize achieving interruption transmission onchocerciasis. Therefore, accelerate elimination onchocerciasis L. co-endemic zones, alternative treatment strategies (ATS) including ground larviciding be necessary. study...
Abstract Background Onchocerciasis transmission in some endemic foci has been persistent despite over 18 years of annual ivermectin mass drug administration (Ivm-MDA). Several reasons including poor adherence to intake due fear severe adverse events (SAEs) areas co-infection with loiasis and the presence numerous breeding sites enhancing abundant vector population contribute this transmission. The change paradigm from onchocerciasis control elimination may not be achieved if alternative...
Background: Onchocerciasis is targeted for elimination with annual community-directed treatment ivermectin (CDTi). High infection levels were reported in South-West Cameroon, despite ≥ 15 years of CDTi. Methods: A large-scale cross-sectional study was conducted 2017 20 communities a loiasis-risk area Cameroon. mixed-methods approach used to evaluate factors associated continued transmission and skin disease. Associations between levels, disease adherence CDTi assessed using mixed regression...