A5093871229- Parasitic Diseases Research and Treatment
- Vector-Borne Animal Diseases
- Parasites and Host Interactions
- Parasite Biology and Host Interactions
- Insect symbiosis and bacterial influences
University of Buea
2024
Biting midges belonging to the genus Culicoides are tiny stout-shaped hematophagous insects and thought transmit filarial nematode Mansonella perstans. Little is known about fauna in rain forest belt of Littoral Region Cameroon. This study was designed investigate diversity, abundance distribution spp. their role as purported vector(s) M. Overnight light trap collections human landing catches (HLCs) revealed eight species with C. grahamii being most abundant followed by milnei. Four...
Introduction Mouse models of human filarial infections are not only urgently needed to investigate the biology nematodes and their modulation host’s immunity, but will also provide a platform screen test novel anti-filarial drugs. Recently, murine Loa loa infection have been stablished using immunocompromised mouse strains, whereas Mansonella perstans implemented until now. Methods Therefore, we aim establish experimental M. strains RAG2IL-2Rγ -/- (lack B, T natural killer cells),...
Mansonella perstans infections are widespread in Sub-Saharan Africa and Central South America thus can be considered as the most prevalent parasite of man tropical Africa. In contrast to high prevalence, knowledge about biology this filarial nematode is restricted no effective treatment regimens ivermectin-resistant lacking. An obstacle for research that M. resides body cavities have been only rarely recovered during surgery or autopsy. Therefore, alternative methods like vitro culture...
Background Mansonella perstans is transmitted by Culicoides species and affects hundred millions of inhabitants in about 33 countries sub-Saharan Africa. It known that Mansonellosis due to do not result a clear clinical picture, but down-regulates the immunity patients predisposing them other diseases like tuberculosis, HIV malaria or damping vaccine efficacy. However, research novel drugs against this filarial nematode missing because lack parasite material. Previous studies have developed...