A5046989443- Parasitic Diseases Research and Treatment
- Insects and Parasite Interactions
- Parasite Biology and Host Interactions
- Insect symbiosis and bacterial influences
- Parasites and Host Interactions
- Dermatological diseases and infestations
- Mosquito-borne diseases and control
- Biosensors and Analytical Detection
- Health Systems, Economic Evaluations, Quality of Life
- Vector-Borne Animal Diseases
- Chronic Disease Management Strategies
- Lymphatic System and Diseases
- Nematode management and characterization studies
University of Buea
2020-2024
Liverpool School of Tropical Medicine
2024
German Center for Infection Research
2024
Conventional diagnosis of filarial infections is based on morphological identification microfilariae using light microscopy and requires considerable expertise, time-consuming, can be subjective. Loop-mediated isothermal amplification (LAMP) has advantages over or PCR because its operational simplicity, rapidity versatility readout options. LAMP assays represent a major step forward in improved diagnostic tools suitable for low resource settings field applicability. The study goal was to...
Biting midges belonging to the genus Culicoides are tiny stout-shaped hematophagous insects and thought transmit filarial nematode Mansonella perstans. Little is known about fauna in rain forest belt of Littoral Region Cameroon. This study was designed investigate diversity, abundance distribution spp. their role as purported vector(s) M. Overnight light trap collections human landing catches (HLCs) revealed eight species with C. grahamii being most abundant followed by milnei. Four...
The diagnosis of onchocerciasis in endemic areas has been demanding given the need to replace invasive skin snip method with a more sensitive and specific rapid point-of-contact tool. Filarial antigen detection tests are better alternative methods diagnosing Onchocercal infections, as they detect infections could be used monitor transmission following mass drug administration. With shift paradigme from control elimination, point- of-contact tool is required support elimination programs. This...
Ivermectin is an excellent microfilaricide against Onchocerca volvulus. However, in some regions, long term use of ivermectin has resulted sub-optimal responses to the treatment. More data properly document phenomenon various contexts mass drug administration (IVM-MDA) needed. Also, there a need accurately monitor possible repopulation skin by microfilariae following Skin snip microscopy known have low sensitivity individuals with light infections, which can be case This study was designed...
Background The impact of large scale Mass Drug Adminstration (MDA) ivermectin on active onchocerciasis transmission by Simulium damnosum , which transmits the parasite O . volvulus is great importance for control programmes. We investigated in Mbam river system area, MDA entomological indices and also verify if there are factors that could have favoured this area contribute to persistence disease. compared three independent techniques detect Onchocerca larvae blackflies analyzed within 9...
Onchocerciasis is a neglected tropical disease targeted for elimination using ivermectin mass administration. Ivermectin kills the microfilariae and temporarily arrests production by macrofilariae. We genotyped 436 from 10 people each in Ituri, Democratic Republic of Congo (DRC), Maridi County, South Sudan, collected before 4–5 months after treatment. Population genetic analyses identified 52 103 mitochondrial DNA haplotypes among DRC respectively, with few shared between people. The...
The control of lymphatic filariasis (LF) caused by Wuchereria bancrofti in the Central African Region has been hampered presence Loa loa due to severe adverse events that arise treatment with ivermectin. immunochromatographic test (ICT) cards used for mapping LF demonstrated cross-reactivity L. and posed problem delineating map. To verify endemicity forest areas Cameroon where mass drug administration (MDA) not ongoing, we recently developed strategy combined serology, microscopy molecular...
Abstract Background The mass drug administration of ivermectin for onchocerciasis control has contributed to a significant drop in Loa loa microfilaria loads humans that has, turn, led reduction infection levels Chrysops vectors. Accurate parasite detection is essential assessing loiasis transmission as it provides potential alternative or indirect strategy addressing the problem co-endemic and lymphatic filariasis through Onchocerciasis Elimination Programme further reflects true magnitude...
Loiasis is an endemic filarial infection in the rainforest zone of West and Central Africa. Repeated annual community-directed treatment with ivermectin (CDTI) delivered for several years to control onchocerciasis has been shown reduce prevalence intensity some
Abstract Background Prior to carrying out clinical trials, it is important assess the health status of study participants be able interpret subsequent changes that may related effects treatments during follow-up patients. This presents clinical, haematological and biochemical profiles podoconiosis patients prior their involvement in PodoLEDoxy trial. Methods All lower limb lymphoedema visiting centre were screened a diagnosis was based on manifestation detailed medical history. Patients who...
Abstract Background Onchocerciasis transmission in some endemic foci has been persistent despite over 18 years of annual ivermectin mass drug administration (Ivm-MDA). Several reasons including poor adherence to intake due fear severe adverse events (SAEs) areas co-infection with loiasis and the presence numerous breeding sites enhancing abundant vector population contribute this transmission. The change paradigm from onchocerciasis control elimination may not be achieved if alternative...
Abstract Background/Objective The Mass Drug Administration of ivermectin for onchocerciasis control has contributed to a significant drop in Loa loa microfilaria loads humans that led reduction the levels infection Chrysops vectors. Accurate parasite detection is essential success any filariasis program. Although microscopy gold standard detecting infection, its sensitivity compromised when intensity low. Loop-mediated isothermal amplification (LAMP) DNA an alternative method which offers...
Abstract Background Ivermectin is an excellent microfilaricide against Onchocerca volvulus. However, in some regions, long term use of ivermectin has resulted sub-optimal responses to the treatment. More data properly document phenomenon various contexts mass drug administration (IVM-MDA) needed. Also, there a need accurately monitor possible repopulation skin by microfilariae following Microscopy known have low sensitivity detect microfilariae, when their density This study was designed...
Abstract Background: The Mass Drug Administration of ivermectin for onchocerciasis control has contributed to a significant drop in Loa loa microfilaria loads humans that led reduction the levels infection Chrysops vectors. Accurate parasite detection is essential assessing loiasis transmission; as such potential alternative or an indirect strategy address problem co-endemic presents LF and elimination programme also, further reflecting true magnitude excess human mortality been reported be...
Abstract Background. Ivermectin is an excellent microfilaricide against Onchocerca volvulus. However, in some regions, long term use of ivermectin has resulted sub-optimal responses to the treatment. More data properly document phenomenon various contexts mass drug administration (IVM-MDA) needed. Also, there a need accurately monitor possible repopulation skin by microfilariae following Skin snip microscopy known have low sensitivity individuals with light infections, which can be case This...
Abstract Background The control of lymphatic filariasis (LF) caused by Wuchereria bancrofti in the Central African Region has been hampered presence Loa loa due to severe adverse events that arise treatment with ivermectin. immunochromatographic test (ICT) cards used for mapping LF demonstrated cross-reactivity L. and posed problem delineating map. To verify endemicity forest areas Cameroon where mass drug administration (MDA) not ongoing, we recently developed strategy combined serology,...
Abstract Background . Ivermectin is an excellent microfilaricide against Onchocerca volvulus. However, in some regions, long term use of ivermectin has resulted sub-optimal responses to the treatment. More data properly document phenomenon various contexts mass drug administration (IVM-MDA) needed. Also, there a need accurately monitor possible repopulation skin by microfilariae following Skin snip microscopy known have low sensitivity individuals with light infections, which can be case...
Abstract Background The control of lymphatic filariasis (LF) caused by Wuchereria bancrofti in the Central African Region has been hampered presence Loa loa due to severe adverse events that arise treatment with ivermectin. immunochromatographic test (ICT) cards used for mapping LF demonstrated cross-reactivity L. and posed problem delineating map. To verify endemicity forest areas Cameroon where mass drug administration (MDA) not ongoing, we recently developed strategy combined serology,...
Abstract Background . Ivermectin is an excellent microfilaricide against Onchocerca volvulus. However, in some regions, long term use of ivermectin has resulted sub-optimal responses to the treatment. More data properly document phenomenon various contexts mass drug administration (IVM-MDA) needed. Also, there a need accurately monitor possible repopulation skin by microfilariae following Skin snip microscopy known have low sensitivity individuals with light infections, which can be case...