A5027055495- Parasites and Host Interactions
- Parasite Biology and Host Interactions
- Global Maternal and Child Health
- Parasitic Diseases Research and Treatment
- Helminth infection and control
- Child Nutrition and Water Access
- Mosquito-borne diseases and control
- Combustion and Detonation Processes
- Risk and Safety Analysis
- Zoonotic diseases and public health
- Graphite, nuclear technology, radiation studies
- Parasitic Infections and Diagnostics
Erasmus MC
2019-2024
Radboud University Nijmegen
2022-2024
Radboud University Medical Center
2022-2024
University Medical Center
2024
Rotterdam University of Applied Sciences
2024
University Hospital and Clinics
2024
University of Oxford
2022
Swiss Tropical and Public Health Institute
2022
University of Basel
2022
Imperial College London
2022
Abstract Due to the COVID-19 pandemic, many key neglected tropical disease (NTD) activities have been postponed. This hindrance comes at a time when NTDs are progressing towards their ambitious goals for 2030. Mathematical modelling on several NTDs, namely gambiense sleeping sickness, lymphatic filariasis, onchocerciasis, schistosomiasis, soil-transmitted helminthiases (STH), trachoma, and visceral leishmaniasis, shows that impact of this disruption will vary across diseases. Programs face...
Abstract Background On 1 April 2020, the WHO recommended an interruption of all activities for control neglected tropical diseases, including soil-transmitted helminths (STH), in response to COVID-19 pandemic. This paper investigates impact this disruption on progress towards 2030 target STH. Methods We used two stochastic individual-based models simulate missing one or more preventive chemotherapy (PC) rounds different endemicity settings. also investigated extent which can be lessened by...
Starting and stopping preventive chemotherapy (PC) for soil-transmitted helminthiasis is typically based on the prevalence of infection as measured by Kato-Katz (KK) fecal smears. Kato-Katz-based egg counts can vary highly over repeated stool samples Consequentially, sensitivity KK-based surveys depends number per person smears sample. Given finite resources, collecting multiple and/or means screening fewer individuals, thereby lowering statistical precision estimates. Using population-level...
Background Soil-transmitted helminths affect almost 2 billion people globally. Hookworm species contribute to most of the related morbidity. Hookworms mainly cause anaemia, due blood loss at site attachment adult worms human intestinal mucosa. The World Health Organization (WHO) aims eliminate hookworm morbidity by 2030 through achieving a prevalence moderate and heavy intensity (M&HI) infections below 2%. In this paper, we aim assess suitability threshold reflect hookworm-attributable...
Background The transmission cycle of Schistosoma is remarkably complex, including sexual reproduction in the human hosts and asexual intermediate host (freshwater snails). Patterns rapid recrudescence after treatment stable low are often observed, hampering achievement control targets. Current mathematical models commonly assume regulation to occur at worm level through density-dependent egg production. However, conclusive evidence on this regulating mechanism weak, especially for S....
Background The transmission cycle of Schistosoma is remarkably complex, including sexual reproduction in human hosts and asexual the intermediate host (freshwater snails). Patterns rapid recrudescence after treatment stable low are often observed, hampering achievement control targets. Current mathematical models commonly assume regulation to occur at worm level through density-dependent egg production. However, conclusive evidence on this regulating mechanism weak, especially for S ....
Abstract Background Soil-transmitted helminths (STHs) are a major cause of poor health in low- and middle-income countries. In particular, hookworm is known to anaemia children women reproductive age (WRA). One goal the World Health Organization’s (WHO) 2030 roadmap for neglected tropical diseases reduce STH-related morbidity WRA. As minimal intervention, WHO recommends deworming adolescent girls annually during human papilloma virus vaccination programmes WRA pregnancy lactation. These...
The design and evaluation of control programs for soil-transmitted helminths (STHs) is based on surveillance data recording measurements egg counts in the stool infected individuals, which underpin estimates prevalence average intensity infection. There considerable uncertainty around these their interpretation. composed several sources measurement error limit detection fecal smear tests one hand, key assumptions STH biology other including aggregation worms within hosts impact...
Abstract Background On the 1 st of April 2020, World Health Organization (WHO) recommended an interruption all neglected tropical disease control programmes, including soil-transmitted helminths (STH), in response to COVID-19 pandemic. This paper investigates impact this disruption on achieved progress towards WHO 2030 target for STH. Methods We used two stochastic individual-based models simulate missing one or more preventive chemotherapy (PC) rounds different endemicity settings. also...
Abstract Background: Soil-transmitted helminths (STHs) are a major cause of poor health in low- and middle-income countries. In particular, hookworm is known to anaemia children women reproductive age (WRA). One goal the World Health Organization’s (WHO) 2030 roadmap for neglected tropical diseases reduce STH-related morbidity WRA. As minimal intervention WHO recommends deworming adolescent girls annually during human papilloma virus vaccination programmes (WRA) pregnancy lactation. These...
Abstract Background Soil-transmitted helminths affect almost 2 billion people globally. Hookworm species contribute to most of the related morbidity. Hookworms mainly cause anaemia, due blood loss at site attachment adult worms human intestinal mucosa. The World Health Organization (WHO) aims eliminate hookworm morbidity by 2030 through achieving a prevalence moderate and heavy intensity (M&HI) infections below 2%. In this paper, we aim assess suitability threshold reflect...
Abstract Background: Soil-transmitted helminths (STHs) are a major cause of poor health in low- and middle-income countries. In particular, hookworm is known to anaemia children women reproductive age (WRA). One goal the World Health Organization’s (WHO) 2030 roadmap for neglected tropical diseases reduce STH-related morbidity WRA. As minimal intervention WHO recommends deworming adolescent girls annually during human papilloma virus vaccination programmes (WRA) pregnancy lactation. These...
Abstract Background: Soil-transmitted helminths (STHs) are a major cause of poor health in low- and middle-income countries. In particular, hookworm is known to anaemia children women reproductive age (WRA). One goal the World Health Organization’s (WHO) 2030 roadmap for neglected tropical diseases reduce STH-related morbidity WRA. As minimal intervention WHO recommends deworming adolescent girls annually during human papilloma virus vaccination programmes (WRA) pregnancy lactation. These...