A5044373961- Trypanosoma species research and implications
- Mosquito-borne diseases and control
- Insect symbiosis and bacterial influences
- Research on Leishmaniasis Studies
- Vector-Borne Animal Diseases
- Parasites and Host Interactions
- Vector-borne infectious diseases
- Agriculture and Rural Development Research
- Genetic diversity and population structure
- Evolution and Genetic Dynamics
- Parasitic Diseases Research and Treatment
- Lysosomal Storage Disorders Research
- Insect-Plant Interactions and Control
- Insect behavior and control techniques
- Insect Resistance and Genetics
- Zoonotic diseases and public health
- Phytoplasmas and Hemiptera pathogens
- African Studies and Ethnography
- Migration, Identity, and Health
- Helminth infection and control
- Evolution and Paleontology Studies
- CRISPR and Genetic Engineering
- Forensic Entomology and Diptera Studies
- Diptera species taxonomy and behavior
- Insect and Pesticide Research
Université de Montpellier
2018-2024
Centre de Coopération Internationale en Recherche Agronomique pour le Développement
2015-2024
Institut de Recherche pour le Développement
2015-2024
Biologie et Génétique des Interactions Plante-Parasite
2011-2023
Interactions hotes-vecteurs-parasites-environnement dans les maladies tropicales négligées dues aux trypanosomatides
2011-2023
Agropolis International
2002-2023
Sorbonne Université
2019-2021
Pitié-Salpêtrière Hospital
2019
Institut Alfred Fournier
2017
Centre international de recherche-développement sur l'elevage en zone subhumide
2007-2016
Summary Glossina palpalis gambiensis Vanderplank (Diptera: Glossinidae) from West Africa (Senegal and Burkina Faso) were analysed for microsatellite DNA polymorphisms size of the wings. In overall sample a strong heterozygote deficiency was found at two polymorphic loci. It led to highly significant value Fis (within‐sample deficit) in western zone Sideradougou area Faso. Genetic differentiation on macrogeographic scale, i.e. between tsetse coming Senegal Wing measures also differed these...
The final outcome of infection by Trypanosoma brucei gambiense, the main agent sleeping sickness, has always been considered as invariably fatal. While scarce and old reports have mentioned cases self-cure in untreated patients, these studies suffered from lack accurate diagnostic tools available at that time. Here, using most specific sensitive to date, we report on a long-term follow-up (15 years) cohort 50 human African trypanosomiasis (HAT) patients Ivory Coast among whom 11 refused...
Background Gambian sleeping sickness (human African trypanosomiasis, HAT) outbreaks are brought under control by case detection and treatment although it is recognised that this typically only reaches about 75% of the population. Vector capable completely interrupting HAT transmission but not used because considered too expensive difficult to organise in resource-poor settings. We conducted a full scale field trial refined vector technology determine its utility HAT. Methods Findings The...
Background Gambian sleeping sickness or HAT (human African trypanosomiasis) is a neglected tropical disease caused by Trypanosoma brucei gambiense transmitted riverine species of tsetse. A global programme aims to eliminate the as public health problem 2020 and stop transmission 2030. In South Chad, Mandoul area persistent focus where around 100 cases were still diagnosed treated annually until 2013. Pre-2014, control relied solely on case detection treatment, which lead gradual decrease in...
Background Control of gambiense sleeping sickness, a neglected tropical disease targeted for elimination by 2020, relies mainly on mass screening populations at risk and treatment cases. This strategy is however challenged the existence undetected reservoirs parasites that contribute to maintenance transmission. In this study, performed in Boffa focus Guinea, we evaluated value adding vector control medical surveys measured its impact burden. Methods The was divided into two parts (screen...
Human African trypanosomiasis, or sleeping sickness caused by Trypanosoma brucei gambiense, occurs in Western and Central Africa. T. s.l. displays a huge diversity of adaptations host specificities, questions about its reproductive mode, dispersal abilities, effective size remain under debate. We have investigated genetic variation at 8 microsatellite loci b. gambiense strains isolated from human trypanosomiasis patients the Ivory Coast Guinea, with aim knowing how information was...
The success of current control tools in combatting malaria vectors is well established. However, sustained residual transmission Plasmodium parasites persists. Mass drug administration (MDA) to humans the endectocide ivermectin for vector receiving increasing attention. feeding upon animals escape this promising approach. Zoophagy mosquitoes sustains both population and endemic vector-borne pathogens. Therefore, only a strategy that will combine MDAs targeted at their peridomestic could be...
Profiling of wild and laboratory tsetse populations using 16S rRNA gene amplicon sequencing allowed us to examine whether the "Wigglesworthia-Sodalis-Wolbachia dogma" operates across species populations. The most abundant taxa, in populations, were Wigglesworthia (the primary endosymbiont), Sodalis Wolbachia as previously characterized. richness microbiota was greater than Spiroplasma identified a new symbiont exclusively Glossina fuscipes G. tachinoides, members palpalis sub-group,...
Sleeping sickness, or Human African Trypanosomiasis (HAT), is caused by two distinct parasites. In East and Southern Africa, Trypanosoma brucei rhodesiense causes the Rhodesian form of disease (about 2% all reported cases [1]). Central West T. b. gambiense Gambian (G-HAT—about 98% The normally affects remote rural communities. people most at risk are those working outdoors for long periods, as they exposed to bite tsetse fly (Glossina spp.: Diptera), which transmits comparable diseases occur...
Important control efforts have led to a significant reduction of the prevalence human African trypanosomiasis (HAT) in Côte d'Ivoire, but disease is still present several foci. The existence an animal reservoir Trypanosoma brucei gambiense may explain persistence these foci where breeding important source income (AAT) unknown. aim this study was identify trypanosome species circulating domestic animals both Bonon and Sinfra HAT endemic foci.552 (goats, pigs, cattle sheep) were included....
Abstract Background In recent years, a programme of vector control, screening and treatment gambiense human African trypanosomiasis (gHAT) infections led to rapid decline in cases the Mandoul focus Chad. To represent biology transmission between humans tsetse, we previously developed mechanistic model, fitted data 2000 2013 which suggested that was interrupted by 2015. The present study outlines refinements model to: (1) Assess whether elimination has already been achieved despite low-level...
In a sleeping sickness focus of Côte d'Ivoire, trypanosomes were characterized in humans, pigs and tsetse using various techniques. Out 74 patients, all the 43 stocks isolated by KIVI (Kit for Vitro Isolation) appeared to belong only one zymodeme Trypanosoma brucei gambiense group 1 (the major Z3). The stock on rodents belonged different, new, (Z50), T. b. 1. From 18 sampled same locations as PCR showed high proportion mixed infections s. l. congolense riverine-forest. Zymodemes from these...
Field studies were done of the responses Glossina palpalis in Côte d'Ivoire, and G. p. gambiensis tachinoides Burkina Faso, to odours from humans, cattle pigs. Responses measured either by baiting (1.) biconical traps or (2.) electrocuting black targets with natural host odours. The catch was significantly enhanced (∼5×) odour but not humans. In contrast, catches electric showed inconsistent results. For both human increased (>2×) trap targets. palpalis, pigs humans numbers tsetse attracted...
Background Because of its high sensitivity and ease use in the field, card agglutination test for trypanosomiasis (CATT) is widely used mass screening sleeping sickness. However, CATT exhibits false-positive results (i) raising question whether CATT-positive subjects who are negative parasitology truly exposed to infection (ii) making it difficult evaluate Trypanosoma brucei (T.b.) gambiense still circulating areas low endemicity. The objective this study was assess value immune trypanolysis...
Background The Government of Senegal has initiated the "Projet de lutte contre les glossines dans Niayes" to remove trypanosomosis problem from this area in a sustainable way. Due past failures sustainably eradicate Glossina palpalis gambiensis Niayes area, controversies remain as best strategy implement, i.e. "eradication" versus "suppression." To inform debate, we used population genetics measure genetic differentiation between G. and those southern tsetse belt (Missira)....
We are attempting to develop cost-effective control methods for the important vector of sleeping sickness, Glossina fuscipes spp. Responses tsetse flies (in Kenya) and G. f. quanzensis Democratic Republic Congo) natural host odours reported. Arrangements electric nets were used assess effect cattle-, human- pig-odour on (1) numbers attracted odour source (2) proportion that landed a black target (1×1 m). In addition responses monitor lizard (Varanus niloticus) assessed in Kenya. The effects...
Background Tsetse flies of the Palpalis group are main vectors sleeping sickness in Africa. Insecticide impregnated targets one most effective tools for control. However, cost these devices still represents a constraint to their wider use. The objective was therefore improve effectiveness currently used devices. Methodology/Principal Findings Experiments were performed on three tsetse species, namely Glossina palpalis gambiensis and G. tachinoides Burkina Faso p. Côte d'Ivoire. 1×1 m2 black...
Control of the Riverine (Palpalis) group tsetse flies is normally achieved with stationary artificial devices such as traps or insecticide-treated targets. The efficiency biconical (the standard control device), 1×1 m black targets and small 25×25 cm flanking nets was compared using electrocuting sampling methods. work done on Glossina tachinoides G. palpalis gambiensis (Burkina Faso), fuscipes quanzensis (Democratic Republic Congo), f. martinii (Tanzania) (Kenya). killing effectiveness...
OPINION article Front. Cell. Infect. Microbiol., 31 July 2013Sec. Clinical Microbiology https://doi.org/10.3389/fcimb.2013.00033