A5008865388- Trypanosoma species research and implications
- Research on Leishmaniasis Studies
- Parasites and Host Interactions
- Insect symbiosis and bacterial influences
- Vector-borne infectious diseases
- Parasitic Diseases Research and Treatment
- Vector-Borne Animal Diseases
- Mosquito-borne diseases and control
- Evolution and Genetic Dynamics
- Lysosomal Storage Disorders Research
- Cytomegalovirus and herpesvirus research
- Rabies epidemiology and control
- MicroRNA in disease regulation
- T-cell and Retrovirus Studies
- Blood Pressure and Hypertension Studies
- African Botany and Ecology Studies
- Ethnobotanical and Medicinal Plants Studies
- Infectious Encephalopathies and Encephalitis
- Diagnosis and treatment of tuberculosis
- Virology and Viral Diseases
- Liver Disease Diagnosis and Treatment
- Poxvirus research and outbreaks
- Renal Diseases and Glomerulopathies
- Complement system in diseases
- Pancreatitis Pathology and Treatment
Nazi Boni University
2016-2025
Centre international de recherche-développement sur l'elevage en zone subhumide
2015-2024
Centre Hospitalier Universitaire Yalgado Ouédraogo
2021
University of Koudougou
2021
Centre de Coopération Internationale en Recherche Agronomique pour le Développement
2011-2015
Institut de Recherche pour le Développement
2011
The final outcome of infection by Trypanosoma brucei gambiense, the main agent sleeping sickness, has always been considered as invariably fatal. While scarce and old reports have mentioned cases self-cure in untreated patients, these studies suffered from lack accurate diagnostic tools available at that time. Here, using most specific sensitive to date, we report on a long-term follow-up (15 years) cohort 50 human African trypanosomiasis (HAT) patients Ivory Coast among whom 11 refused...
Evolutionary theory predicts that the lack of recombination and chromosomal re-assortment in strictly asexual organisms results homologous chromosomes irreversibly accumulating mutations thus evolving independently each other, a phenomenon termed Meselson effect. We apply population genomics approach to examine this effect an important human pathogen, Trypanosoma brucei gambiense. determine T.b. gambiense is asexually derived from single progenitor, which emerged within last 10,000 years....
Human African trypanosomiasis (HAT), or sleeping sickness, is caused by two subspecies of the protozoan parasite Trypanosoma brucei (T.b.) and transmitted through tsetse flies (Glossina sp.). T.b. gambiense occurs from West to Central sub-Sahara Africa, while rhodesiense endemic in East Africa. Other closely related taxa (T.b. brucei, T. evansi, equiperdum, congolense, vivax) cause animal trypanosomiases domestic animals like cattle, horse, camel, goat, sheep, buffalo Latin America, Europe,...
Important control efforts have led to a significant reduction of the prevalence human African trypanosomiasis (HAT) in Côte d'Ivoire, but disease is still present several foci. The existence an animal reservoir Trypanosoma brucei gambiense may explain persistence these foci where breeding important source income (AAT) unknown. aim this study was identify trypanosome species circulating domestic animals both Bonon and Sinfra HAT endemic foci.552 (goats, pigs, cattle sheep) were included....
Background Because of its high sensitivity and ease use in the field, card agglutination test for trypanosomiasis (CATT) is widely used mass screening sleeping sickness. However, CATT exhibits false-positive results (i) raising question whether CATT-positive subjects who are negative parasitology truly exposed to infection (ii) making it difficult evaluate Trypanosoma brucei (T.b.) gambiense still circulating areas low endemicity. The objective this study was assess value immune trypanolysis...
Gambiense human African trypanosomiasis (g-HAT) is the chronic form of sleeping sickness caused by Trypanosoma brucei gambiense in West and Central Africa, while rhodesiense causes an acute eastern Africa. g-HAT targeted for elimination as a public health problem 2020 0 transmission 2030 [1,2]. Control largely based on identification treatment infected individuals, supplemented control tsetse fly vectors [3]. There has been growing evidence that when both case activities are carried out...
Abstract Background Serological screening tests play a crucial role to diagnose gambiense human African trypanosomiasis (gHAT). Presently, they preselect individuals for microscopic confirmation, but in future “screen and treat” strategies will identify treatment. Variability reported specificities, the development of new rapid diagnostic (RDT) hypothesis that malaria infection may decrease RDT specificity led us evaluate 5 gHAT tests. Methods During active screening, venous blood samples...
Summary Objectives To evaluate a modification of the mini anion exchange centrifugation test (mAECT) for diagnosis Trypanosoma brucei ( T.b. ) gambiense human African trypanosomiasis (HAT). increase its sensitivity, this uses 350 μl buffy coat withdrawn from 5 ml blood instead blood. Methods The new protocol was first tested experimentally on serial dilution trypanosomes and then further evaluated under field conditions 57 patients with HAT diagnosed during medical survey in Guinea. Results...
Background Little is known about the diagnostic performance of rapid tests (RDTs) for passive screening human African trypanosomiasis (HAT) in Côte d’Ivoire. We determined HAT prevalence among clinical suspects, identified symptoms and signs associated with RDT positivity, assessed tests’ specificity, positive predictive value agreement. Methods Clinical suspects were screened SD Bioline HAT, Sero- K -Set rHAT Sero-Strip. Seropositives parasitologically examined, their dried blood spots...
Passive diagnosis of human African trypanosomiasis (HAT) at the health facility level is a major component HAT control in Guinea. We examined which clinical signs and symptoms are associated with HAT, assessed performance selected presentations, rapid diagnostic tests (RDT), reference laboratory on dried blood spots (DBS) for diagnosing Guinea.The study took place 14 facilities Guinea, where 2345 suspects were tested RDTs (HAT Sero-K-Set, rHAT Sero-Strip, SD Bioline HAT). Seropositives...
Background Human African trypanosomiasis (HAT), a lethal disease induced by Trypanosoma brucei gambiense, has range of clinical outcomes in its human host West Africa: an acute form progressing rapidly to second stage, spontaneous self-cure and individuals able regulate parasitaemia at very low levels, have all been reported from endemic foci. In order test if this diversity is influenced genetic determinants, the association between candidate gene polymorphisms HAT outcome was investigated...
The existence of an animal reservoir Trypanosoma brucei gambiense (T. b. gambiense), the agent human African trypanosomiasis (HAT), may compromise interruption transmission targeted by World Health Organization. aim this study was to investigate presence trypanosomes in pigs and people Vavoua HAT historical focus where cases were still diagnosed early 2010's.For survey, we used CATT, mini-anion exchange centrifugation technique immune trypanolysis tests. For buffy coat also as well PCR using...
The skin is an anatomical reservoir for African trypanosomes, yet the prevalence of extravascular parasite carriage in population at risk gambiense Human Trypanosomiasis (gHAT) remains unclear. Here, we conducted a prospective observational cohort study HAT foci Forecariah and Boffa, Republic Guinea. Of 18,916 subjects serologically screened gHAT, 96 were enrolled into our study. At enrolment follow-up visits, participants underwent dermatological examination had blood samples superficial...
The World Health Organisation has targeted the elimination of human African trypanosomiasis (HAT) as zero transmission by 2030. Continued surveillance needs to be in place for early detection re-emergent cases. In this context, performance diagnostic tests and testing algorithms re-emergence Trypanosoma brucei gambiense HAT remains assessed. We carried out a door-to-door active medical survey historical focus Batié, South–West Burkina Faso. Screening was done using three rapid (RDTs). Two...
Pathogens and their vectors are organisms whose ecology is often only accessible through population genetics tools based on spatio-temporal variability of molecular markers. However, may present technical difficulties due to the masking some alleles (allelic dropouts and/or null alleles), which tends bias estimation heterozygosity thus inferences concerning breeding system organism under study. This especially critical in clonal deviation from panmixia, as measured by Wright's FIS, can,...
The World Health Organization (WHO) has set the goal of gambiense-Human African trypanosomiasis (HAT) elimination as a public health problem for 2020 and interruption transmission in humans 2030. In this context, it is crucial to monitor progress towards these targets using accurate tools assess level given area. aim study was investigate relevance immune trypanolysis test (TL) population-based bioassay evaluate Trypanosoma brucei gambiense various epidemiological contexts. Significant...
Although studies on African Trypanosomiases revealed a variety of trypanosome species in the blood various animal taxa, reservoirs Trypanosoma brucei gambiense and anatomical niches such as skin have been overlooked most epidemiological settings. This study aims to update data infections animals from human trypanosomiasis (HAT) foci Cameroon. Blood snips were collected 291 domestic wild animals. DNA was extracted molecular approaches used identify different trypanosomes species....
African Animal Trypanosomosis (AAT) is a chronic debilitating disease affecting the productivity of livestock. In order to provide useful information on clinical manifestation, and species prevalence haematological alterations associated with trypanosome infection in pigs from Federal Capital Territory Nasarawa states, blood was collected 395 pigs. Diagnosis Trypanosoma were done clinically, using microscopy, serology (immune trypanoslysis test) molecular detection. Observed manifestations...