A5057699085- Trypanosoma species research and implications
- Insect symbiosis and bacterial influences
- Research on Leishmaniasis Studies
- Helminth infection and control
- Vector-Borne Animal Diseases
- Mosquito-borne diseases and control
- Viral gastroenteritis research and epidemiology
- Animal Virus Infections Studies
- Cytomegalovirus and herpesvirus research
- SARS-CoV-2 and COVID-19 Research
- Calcium signaling and nucleotide metabolism
Liverpool School of Tropical Medicine
2020-2024
University of Surrey
2019-2023
University of Edinburgh
2023
Roslin Institute
2023
Gambiense human African trypanosomiasis (g-HAT) is the chronic form of sleeping sickness caused by Trypanosoma brucei gambiense in West and Central Africa, while rhodesiense causes an acute eastern Africa. g-HAT targeted for elimination as a public health problem 2020 0 transmission 2030 [1,2]. Control largely based on identification treatment infected individuals, supplemented control tsetse fly vectors [3]. There has been growing evidence that when both case activities are carried out...
Abstract Animal African trypanosomiasis (AAT) is a significant food security and economic burden in sub-Saharan Africa. Current AAT empirical immunodiagnostic surveillance tools suffer from poor sensitivity specificity, with blood sampling requiring animal restraint trained personnel. Faecal could increase accessibility, scale, species range. Therefore, this study assessed feasibility of detecting Trypanosoma DNA the faeces experimentally-infected cattle. Holstein–Friesian calves were...
Abstract Disease surveillance in wildlife populations presents a logistical challenge, yet is critical gaining deeper understanding of the presence and impact pathogens. Erinaceus coronavirus (EriCoV), clade C Betacoronavirus , was first described Western European hedgehogs ( europaeus ) Germany. Here, our objective to determine whether EriCoV present, if it associated with disease, Great Britain (GB). An EriCoV-specific BRYT-Green ® real-time reverse transcription PCR assay used test 351...
Background Tsetse flies ( Glossina sp.) are vectors of Trypanosoma brucei subspecies that cause human African trypanosomiasis (HAT). Capturing and screening tsetse is critical for HAT surveillance. Classically, have been microscopically analysed to identify trypanosomes, but this increasingly replaced with molecular xenomonitoring. Nonetheless, sensitive T . -detection assays, such as TBR-PCR, vulnerable DNA cross-contamination. This may occur at capture, when often multiple live retained...
Human African Trypanosomiasis (HAT) is a potentially fatal parasitic infection caused by the trypanosome sub-species Trypanosoma brucei gambiense and T . b rhodesiense transmitted tsetse flies. Currently, global HAT case numbers are reaching less than 1 per 10,000 people in many disease foci. As such, there need for simple screening tools strategies to replace active of human population which can be maintained post-elimination Gambian long-term Rhodesian HAT. Here, we describe proof...
Abstract Animal African trypanosomiasis (AAT) is a significant food security and economic burden in sub-Saharan Africa. Current AAT surveillance tools suffer from poor sensitivity specificity, with blood sampling requiring animal restraint trained personnel. Faecal could increase accessibility, scale, host species range. Therefore, this study assessed feasibility of detecting Trypanosoma DNA the faeces experimentally-infected cattle. Holstein-Friesian calves were inoculated brucei AnTat 1.1...
Abstract Background Tsetse flies ( Glossina sp .) are vectors of Trypanosoma brucei subspecies that cause human African trypanosomiasis (HAT). Capturing and screening tsetse is critical for HAT surveillance. Classically, have been microscopically analysed to identify trypanosomes, but this increasingly replaced with molecular xenomonitoring. Nonetheless, sensitive T. -detection assays, such as TBR-PCR, vulnerable DNA cross-contamination. This may occur at capture, when often multiple live...
Abstract Background Human African Trypanosomiasis (HAT) is a potentially fatal parasitic infection caused by the trypanosome sub-species Trypanosoma brucei gambiense and T. b. rhodesiense transmitted tsetse flies. Currently, global HAT case numbers are reaching less than 1 per 10,000 people in many disease foci. As such, there need for simple screening tools strategies to replace active of human population which can be maintained post-elimination Gambian long-term Rhodesian HAT. Here we...