A5089239945- Salmonella and Campylobacter epidemiology
- Viral gastroenteritis research and epidemiology
- Vibrio bacteria research studies
- Global Maternal and Child Health
- Human Pose and Action Recognition
- Chronic Disease Management Strategies
- Viral Infections and Outbreaks Research
- Child Nutrition and Water Access
- Adolescent Sexual and Reproductive Health
- Tuberculosis Research and Epidemiology
- Global Health and Epidemiology
- Immune Response and Inflammation
- Hepatitis B Virus Studies
- Cutaneous Melanoma Detection and Management
- Glaucoma and retinal disorders
- Health disparities and outcomes
- Vaccine Coverage and Hesitancy
- Hand Gesture Recognition Systems
- Healthcare Systems and Reforms
- Global Cancer Incidence and Screening
- Clostridium difficile and Clostridium perfringens research
- Child and Adolescent Health
- Global Health Care Issues
- Frailty in Older Adults
- Cancer survivorship and care
Malawi-Liverpool-Wellcome Trust Clinical Research Programme
2018-2025
Kamuzu University of Health Sciences
2022-2025
University of Liverpool
2018-2025
International Institute for Population Sciences
2020-2024
Centurion University of Technology and Management
2022-2024
New York University
2024
Old Dominion University
2023-2024
University of Michigan–Ann Arbor
2024
Max Planck Institute for Intelligent Systems
2023
Royal Brompton Hospital
2023
Typhoid fever caused by multidrug-resistant H58 Salmonella Typhi is an increasing public health threat in sub-Saharan Africa.We conducted a phase 3, double-blind trial Blantyre, Malawi, to assess the efficacy of Vi polysaccharide typhoid conjugate vaccine (Vi-TCV). We randomly assigned children who were between 9 months and 12 years age, 1:1 ratio, receive single dose Vi-TCV or meningococcal capsular group A (MenA) vaccine. The primary outcome was confirmed blood culture. report safety...
We show, for the first time, that neural networks trained only on synthetic data achieve state-of-the-art accuracy problem of 3D human pose and shape (HPS) estimation from real images. Previous datasets have been small, unrealistic, or lacked realistic clothing. Achieving sufficient realism is non-trivial we show how to do this full bodies in motion. Specifically, our BEDLAM dataset contains monocular RGB videos with ground-truth SMPL-X format. It includes a diversity body shapes, motions,...
BackgroundRandomised controlled trials of typhoid conjugate vaccines among children in Africa and Asia have shown high short-term efficacy. Data on the durability protection beyond 2 years are sparse. We present final analysis a randomised trial Malawi, encompassing more than 4 follow-up, with aim investigating vaccine efficacy over time by age group.MethodsIn this phase 3, double-blind, Blantyre, healthy aged 9 months to 12 were randomly assigned (1:1) an unmasked statistician receive...
Abstract Background Tuberculosis, as a communicable disease, is an ongoing global epidemic that accounts for high burden of mortality and morbidity. Globally, with estimated 10 million new cases around 1.4 deaths, TB has emerged one the top causes morbidity in 2019. Worst hit 8 countries account two thirds 2019, India leading count. Despite India's engagement various control activities since its first recognition through resolution passed All-India Sanitary Conference 1912 launch National...
Cervical cancer is the fourth most common that occurs to women worldwide. This study aims assess trends in incidence and mortality of cervical India its states over past three decades for tracking progress strategies prevention control cancer.Data on from 1990 2019 were extracted Global Burden Disease utilized analysis. Spatial rank map has been used see changes different Indian states. Further, joinpoint regression analysis applied determine magnitude time age standardized rates cancer. We...
Around the world, advances in public health and changes clinical interventions have resulted increased life expectancy. Multimorbidity is becoming more of an issue, particularly countries where population rapidly ageing. We aimed to determine prevalence multimorbidity disease-specific examine its association with demographic socioeconomic characteristics among older adults India states.The individual data from longitudinal ageing study (LASI) were used for this study, 11 common chronic...
Background Monitoring the transmission patterns of human immunodeficiency virus (HIV) in a population is fundamental for identifying key and designing prevention interventions. In present study, we aimed to estimate gender disparities HIV incidence age, period, cohort effects on India predictors that might have led changes last three decades. Data methods This study utilizes data from Global Burden Disease Study period 1990–2019. The joinpoint regression analysis was employed identify...
Typhoid fever is a substantial public health problem in Africa, yet there are few clinical trials of typhoid conjugate vaccine (TCV). We assessed immunogenicity and safety Typbar TCV Malawi.
Pregnancy during adolescence is a major risk factor for adverse pregnancy outcomes. Further, Motherhood the adolescent period identified as global health burden. Considering widely known importance of negative impact pregnancy, motherhood at an early age, and outcomes, this paper aims to provide insight into correlates teen outcome. This study utilizes data from UDAYA survey conducted in Uttar Pradesh Bihar. The eligible sample size was 4897 married girls between ages 15 19 years. Bivariate...
Abstract: The "Designing and Implementation of Disease Prediction Application Using Machine Learning" project aims to develop an innovative healthcare solution that leverages machine learning techniques predict diseases based on userprovided symptoms. system involves a user interface where patients can input their symptoms through chat box. These symptom descriptions are then processed using predefined prompt in Palm API. API returns the predicted disease, which is displayed screen. This...
Abstract Background Globally, most children seek emergency care at general rather than specialized pediatric departments. There remains significant variation in the provision of care, particularly resource-constrained settings. The objective this study is to pilot a self-assessment tool evaluate capabilities low- and middle-income country (LMIC) hospitals on African Continent. Methods This was prospective cross-sectional descriptive using convenience sample sub-Saharan hospitals. assessment...
Background: OP poisoning occurs in various state occupational exposures during working farm and pest control, their manufacturing, storage transport. There is limited availability of facilities resources at peripheral centers developing countries all patients are difficult to manage. Hence it important know the clinical features other factors that indicates severity criteria speculate need for early referral which should be identified initial examination.
Objective: To determine in a cohort of TB patients 1) the prevalence diabetes (DM) and impaired fasting glucose (IFG), 2) time taken for diagnosis, 3) demographic clinical factors associated with DM IFG, 4) number needed to screen (NNS) diagnosing new cases IFG.Design: Descriptive study.TB registered between January September 2012 were asked whether they had history DM.Those unknown tested random blood (FBG).FBG ⩾126 mg/dl 110-125 considered indicative respectively.Results: Of 556 patients,...
Typhoid fever is an acute infection characterized by prolonged following the ingestion and subsequent invasion of Salmonella enterica serovar Typhi (S. Typhi), a human-restricted pathogen. The incidence typhoid has been most reported in children 5-15 years age, but increasingly recognized younger than 5 old. There recent expansion multidrug-resistant globally. Prior vaccines were not suitable for use youngest countries with high burden disease. This study aims to determine efficacy conjugate...
Background: Depression is a major public health concern among Indian adolescents. Pre- and post-natal depression can often alter fetal development have negative consequences on the physical mental of mother. This paper aims to draw attention prevalence its correlates currently married, ever-pregnant adolescents from two States, i.e. Uttar Pradesh Bihar. Methods: study utilizes data subsample ( n = 3116) prospective cohort Understanding Lives Adolescents Young Adults (UDAYA) 10 19 year-old...
Ciprofloxacin is the first-line drug for treating typhoid fever in many countries Africa with a high disease burden, but emergence of non-susceptibility poses challenge to public health programmes. Through enhanced surveillance as part vaccine evaluation, we investigated occurrence and potential determinants ciprofloxacin Blantyre, Malawi.
Natural Language Processing (NLP) uses Sentiment Analysis (SA) to determine text sentiment. SA is often used on datasets assess consumer demands, the sentiment of customer for a product, and brand monitoring. Deep Learning (DL) subset Machine (ML) that mimics how humans learn. In this work, Reptile Search Algorithm (SA-DLRSA) model introduced accurate automatic SA. The SA-DLRSA utilizes Word2Vec word embedding reduce language processing dependent data pre-processing. SVM, CNN, RNN, BiLSTM,...
Non-typhoidal Salmonella (NTS) are a major cause of bloodstream infections amongst children in sub-Saharan Africa. A clear understanding the seroepidemiology and correlates protection for invasive NTS (iNTS) relation to key risk factors (malaria, anaemia, malnutrition) Africa is needed inform strategies disease control including vaccine implementation.
Vaccine safety and immunogenicity data in human immunodeficiency virus (HIV)-exposed uninfected (HEU) children are important for decision-making HIV typhoid co-endemic countries. In an open-label study, we recruited Malawian HEU unexposed (HUU) infants aged 9 - 11 months. participants were randomized to receive Vi-tetanus toxoid conjugate vaccine (Vi-TT) at months, Vi-TT 15 or HUU received Safety outcomes included solicited unsolicited adverse events (AE) serious AEs (SAEs) within 7 days, 28...
Typhoid conjugate vaccines are being introduced in low-income and middle-income countries to prevent typhoid illness children. Vaccine effectiveness studies assess vaccine performance after introduction. The test-negative design is a commonly used method estimate that has not been applied because of concerns over blood culture insensitivity. overall aim the study was evaluate appropriateness using Vi polysaccharide-tetanus toxoid (Vi-TT) gold standard randomised controlled trial...
Abstract Background To determine the efficacy of a new typhoid conjugate vaccine in an endemic setting sub-Saharan Africa, Typhoid Vaccine Acceleration Consortium is conducting phase-3 randomized controlled trial Blantyre, Malawi. This article describes community and stakeholder engagement activities before during trial, challenges, lessons learned. Methods In October 2017, Malawi-Liverpool Wellcome Trust (MLW) organized wide range activities, including meetings with Ministry Health...