A5043437996- Malaria Research and Control
- Global Maternal and Child Health
- Mosquito-borne diseases and control
- Trypanosoma species research and implications
- Viral Infections and Outbreaks Research
- Child Nutrition and Water Access
- COVID-19 diagnosis using AI
- Lysosomal Storage Disorders Research
- Research on Leishmaniasis Studies
- Parasites and Host Interactions
- Digital Imaging for Blood Diseases
- Carbohydrate Chemistry and Synthesis
- Tuberculosis Research and Epidemiology
- Ethics in Clinical Research
- Genetics, Bioinformatics, and Biomedical Research
- Drug-Induced Hepatotoxicity and Protection
- Anomaly Detection Techniques and Applications
- Lung Cancer Diagnosis and Treatment
- Lipid metabolism and biosynthesis
- Pancreatic function and diabetes
- Glycosylation and Glycoproteins Research
- Mental Health and Patient Involvement
- Enzyme Catalysis and Immobilization
- Peptidase Inhibition and Analysis
- SARS-CoV-2 detection and testing
Swiss Tropical and Public Health Institute
2021-2025
University of Basel
2021-2024
Cornell University
2009-2013
University of Bern
2007-2008
To prevent child deaths from severe malaria, early parenteral treatment is essential. Yet, in remote rural areas, accessing facilities offering antimalarials may be difficult. A randomised controlled trial found pre-referral with rectal artesunate (RAS) to reduce and disability children who arrived at a referral facility delay. This study examined the effectiveness of RAS implemented through routine procedures established community-based health care systems.An observational accompanied...
The key to reducing malaria deaths in highly endemic areas is prompt access quality case management. Given that many severe cases occur at peripheral level, rectal artesunate (RAS) the form of suppositories was developed 1990s, allowing for rapid initiation life-saving antimalarial treatment before referral a health facility with full management capabilities. One randomized controlled trial published 2009 showed protective effect RAS pre-referral against overall mortality 26%, but...
Artemisinin-based combination therapies (ACTs) were introduced as the standard of care for uncomplicated malaria in Africa almost two decades ago. Recent studies East have reported a gradual increase
Introduction Tuberculosis (TB) remains a significant public health challenge in many African communities, where underreporting and underdiagnosis are prevalent due to barriers accessing care inadequate diagnostic tools. This is particularly concerning hard-to-reach areas with high burden of TB/HIV co-infection, missed or delayed diagnoses exacerbate disease transmission, increase mortality, lead severe economic consequences. To address these challenges, it crucial evaluate innovative,...
Summary Phosphatidylethanolamine (PE) and phosphatidylcholine (PC) are the two major constituents of eukaryotic cell membranes. In protist Trypanosoma brucei , PE PC synthesized exclusively via Kennedy pathway. To determine which organelles or processes most sensitive to a disruption normal phospholipid levels, cellular consequences decrease in levels PC, respectively, were studied following RNAi knock‐down four enzymes against ethanolamine‐phosphate cytidylyltransferase (ET) disrupted...
Children who receive prereferral rectal artesunate (RAS) require urgent referral to a health facility where appropriate treatment for severe malaria can be provided. However, the rapid improvement of child's condition after RAS administration may influence caregiver's decision follow this recommendation. Currently, evidence on effect completion is limited.An observational study accompanied roll-out in three endemic settings Democratic Republic Congo (DRC), Nigeria and Uganda. Community...
Background For a full treatment course of severe malaria, community-administered pre-referral rectal artesunate (RAS) should be completed by post-referral consisting an injectable antimalarial and oral artemisinin-based combination therapy (ACT). This study aimed to assess compliance with this recommendation in children under 5 years. Methods findings observational accompanied the implementation RAS Democratic Republic Congo (DRC), Nigeria, Uganda between 2018 2020. Antimalarial was assessed...
In addition to its conventional role during protein synthesis, eukaryotic elongation factor 1A is involved in other cellular processes. Several regions of interaction between and the translational apparatus or cytoskeleton have been identified, yet roles different post-translational modifications are completely unknown. One amino acid modification, which so far has only found 1A, consists ethanolamine-phosphoglycerol attached two glutamate residues that conserved mammals plants. We now...
Mature dolichol-linked oligosaccharides (mDLOs) needed for eukaryotic protein N-glycosylation are synthesized by a multistep pathway in which the biosynthetic lipid intermediate Man5GlcNAc2-PP-dolichol (M5-DLO) flips from cytoplasmic to luminal face of endoplasmic reticulum. The reticulum membrane Rft1 is intimately involved mDLO biosynthesis. Yeast genetic analyses implicated as M5-DLO flippase, but because biochemical tests challenged this assignment, function remains obscure. To...
Community health workers (CHW) usually refer children with suspected severe malaria to the nearest public facility or a designated referral (RHF). Caregivers do not always follow this recommendation. This study aimed at identifying post-referral treatment-seeking pathways that lead appropriate antimalarial treatment for less than five years malaria. An observational in Uganda enrolled below presenting CHWs signs of Children were followed up 28 days after enrolment assess their condition and...
Evidence suggests that pre-referral Rectal Artesunate (RAS) can be a life-saving intervention for severe malaria in remote settings Africa. Recognition of danger signs indicative is critical prompt and appropriate case management.
Summary Glycosylphosphatidylinositol (GPI) lipids of Trypanosoma brucei undergo lipid remodelling, whereby longer fatty acids on the glycerol are replaced by myristate (C14:0). A similar process occurs GPI proteins Saccharomyces cerevisiae where Per1p first deacylates, Gup1p subsequently reacylates anchor lipid, thus replacing a shorter acid C26:0. Heterologous expression GUP1 homologue T. bruce i in gup1 Δ yeast cells partially normalizes phenotype and restores transfer labelled from...
Abstract Background For children below 6 years with suspected severe malaria attending a health care provider unable to provide parenteral treatment, pre-referral rectal artesunate (RAS) is recommended by the World Health Organization prevent death and disability. A number of African countries are in process rolling out quality-assured RAS for treatment at community-level. The success depends, among other factors, on acceptability communities where it being rolled-out. Yet date, there...
Abstract Background Appropriate clinical management of severe malaria is critical to avert morbidity and death. Recommended treatment consists an injectable antimalarial followed by a full course oral artemisinin-based combination therapy (ACT). Children who cannot access prompt parenteral should be administered single dose rectal artesunate (RAS) promptly referred appropriate facility for further care. This study aimed assess compliance with the recommendation in children under 5 years...
Abstract Background To prevent child deaths from severe malaria, early parenteral treatment is essential. Yet, in remote rural areas, higher-level facilities offering antimalarials are often difficult to access. A randomised controlled trial found pre-referral rectal artesunate (RAS) reduce death and disability children who delay arriving at a referral facility. This study examined the effectiveness of RAS established community-based health care systems. Methods An observational accompanied...
Identification, stabilization, and prompt referral of children with signs severe febrile disease (danger signs) in rural communities are crucial for preventing complications death from malaria, pneumonia, diarrhea. We set out to determine the treatment-seeking practices treatment patterns < 5 years age an acute illness, or without danger disease, a highly malaria-endemic area northern Uganda. Three household surveys were conducted November through December each year 2018, 2019, 2020....
Digital health has gained traction in research and development, clinical decision support systems. The COVID-19 pandemic accelerated the adoption of decentralised trials (DCTs) as a mitigation efficiency improvement strategy. We assessed opportunities challenges digital transformation sub-Saharan Africa from different stakeholders' perspectives.A qualitative study, including 40 in-depth semi structured interviews, was conducted with investigators three leading institutions Switzerland,...
Abstract Introduction Community health workers (CHW) usually refer children with suspected severe malaria to the nearest public facility or a designated referral (RHF). Caregivers do not always follow this recommendation. This study aimed at identifying post-referral treatment-seeking pathways that lead appropriate antimalarial treatment for less than five years malaria. Methods An observational in Uganda enrolled below presenting CHWs signs of Children were followed up 28 days after...
Abstract Background Children who receive pre-referral rectal artesunate (RAS) require urgent referral to a health facility where appropriate treatment for severe malaria can be provided. However, the rapid improvement of child’s condition after RAS administration may influence caregiver’s decision follow this recommendation. Currently, evidence on effect completion is limited. In study, we investigated relationship between implementation and completion. Methods Findings An observational...
Background: The emergence of artemisinin-resistant P. falciparum in Africa has recently been documented several studies. inadequate use artesunate monotherapies is suspected to be a driver this recent emergence. Rectal (RAS) as pre-referral treatment for severe malaria children was implemented 2019 Northern Uganda. objective study determine whether such strategy would result selection resistance.Method: In the frame Community Access Artesunate Malaria project, blood samples were collected...
Malaria remains a major public health issue in the Democratic Republic of Congo (DRC), accounting for 44% deaths among outpatient visits children < 5 years age, and 22% facility deaths. Understanding determinants caregivers' treatment-seeking patterns decision-making is crucial reducing malaria burden.In frame Community Access to Rectal Artesunate (CARAMAL) project, cross-sectional household surveys that randomly sampled villages households were carried-out three rural DRC zones prior...