A5059015465- Global Maternal and Child Health
- Malaria Research and Control
- Health Systems, Economic Evaluations, Quality of Life
- Mosquito-borne diseases and control
- Healthcare Policy and Management
- Child Nutrition and Water Access
- Pharmaceutical Economics and Policy
- Viral Infections and Outbreaks Research
- Parasites and Host Interactions
- Reproductive Health and Contraception
- Hemophilia Treatment and Research
- Global Health Care Issues
- Community Health and Development
- vaccines and immunoinformatics approaches
- Hepatitis Viruses Studies and Epidemiology
- Maternal and Perinatal Health Interventions
- Breast Cancer Treatment Studies
- Primary Care and Health Outcomes
- Vaccine Coverage and Hesitancy
- Travel-related health issues
- Health Policy Implementation Science
- Healthcare cost, quality, practices
- Interprofessional Education and Collaboration
- Advanced Breast Cancer Therapies
- Chronic Lymphocytic Leukemia Research
University of Basel
2014-2024
Swiss Tropical and Public Health Institute
2014-2022
Emory University
2007
The phase 3 trial of the RTS,S/AS01 malaria vaccine candidate showed modest efficacy against Plasmodium falciparum malaria, but was not powered to assess mortality endpoints. Impact projections and cost-effectiveness estimates for longer timeframes than follow-up across a range settings are needed inform policy recommendations. We aimed public health impact routine use in African settings.We compared four transmission models their predictions impact. used data 32 months or parameterise...
Medicare beneficiaries’ medical needs, and where beneficiaries undergo treatment, have changed dramatically over the past two decades. Twenty years ago, most spending growth was linked to intensive inpatient (hospital) services, chiefly for heart disease. Recently, much of has been attributable chronic conditions such as diabetes, arthritis, hypertension, kidney These are treated not in hospitals but outpatient settings by patients at home with prescription drugs. Health reform must address...
Appropriate treatment of life-threatening Plasmodium falciparum malaria requires in-patient care. Although the proportion severe cases accessing care in endemic settings strongly affects overall case fatality rates and thus disease burden, this is generally unknown. At present, estimates mortality are driven by prevalence or clinical incidence data, ignoring differences resulting from variations access. Consequently, impact preventive interventions on burden have not been validly compared...
Scale-up of malaria preventive and control interventions over the last decade resulted in substantial declines mortality morbidity from disease sub-Saharan Africa many other parts world. Sustaining these gains will depend on health system performance. Treatment provides individual benefits by curing infection preventing progression to severe as well community-level reducing infectious reservoir averting emergence spread drug resistance. However patients with do not access care, providers...
Introduction Tools that allow for in silico optimization of available malaria control strategies can assist the decision-making process prioritizing interventions. The OpenMalaria stochastic simulation modeling platform be applied to simulate impact interventions singly and combination as implemented Rachuonyo South District, western Kenya, support this goal. Methods Combinations were simulated using a previously-published, validated model epidemiology study area. An economic costs case...
The United States spends more on health care than any European country. Previous studies have sought to explain these differences in terms of system capacity, access technologies, gross domestic product, and prices. We examine disease prevalence treatment rates for ten the most costly conditions between countries using surveys noninstitutionalized population age fifty older. Disease medication are much higher countries. Efforts reduce U.S. chronic illness should remain a key policy goal.
The RTS,S/AS01 malaria vaccine candidate recently completed Phase III trials in 11 African sites. Recommendations for its deployment will partly depend on predictions of public health impact endemic countries. Previous these used only limited information underlying properties and have not considered country-specific contextual data. Each trial cohort was simulated explicitly using an ensemble individual-based stochastic models, many hypothetical profiles. true profile estimated by Bayesian...
Hybrid trials that include both clinical and implementation science outcomes are increasingly relevant for public health researchers aim to rapidly translate study findings into evidence-based practice. The DeWorm3 Project is a series of hybrid testing the feasibility interrupting transmission soil transmitted helminths (STH), while conducting research contextualizes provides guidance on opportunities optimize delivery STH interventions. purpose studies ensure rapid efficient translation...
Haemophilia B is a rare genetic disease that caused by deficiency of coagulation factor IX (FIX) in the blood and leads to internal external bleeding. Under current standard care, haemophilia treated either prophylactically or on-demand via intravenous infusions FIX. These treatment strategies impose high burden on patients health care systems as requires lifelong treatment, FIX costly. Etranacogene dezaparvovec (ED) gene therapy for has been recently approved United States Food Drug...
Recent results from the phase 3 trial of RTS,S/AS01 malaria vaccine show that induced partial protection against clinical in infants and children; given high burden disease it is currently considered for use endemic countries. To inform adoption decisions paper proposes a generalizable methodology to estimate cost introduction using routinely collected publicly available data cMYP, UNICEF, WHO-CHOICE. Costing carried out around set generic activities, assumptions, inputs delivery...
RTS,S/AS01 is a safe and moderately efficacious vaccine considered for implementation in endemic Africa. Model predictions of impact cost-effectiveness this new intervention could aid country adoption decisions.The RTS,S was assessed 43 countries using an ensemble models Plasmodium falciparum epidemiology. Informed by the 32months follow-up data from phase 3 trial, effectiveness evaluated at levels malaria parasite prevalence, coverage control interventions immunization. Benefits costs...
Scale-up of malaria interventions over the last decade have yielded a significant reduction in transmission and disease burden sub-Saharan Africa. We estimated economic gradients distribution these efforts their impacts within across endemic countries.Using Demographic Health Surveys we computed equity metrics to characterize 30 countries proxying position with an asset-wealth index. Gradients were summarized concentration index, tabulated against level coverage, compared among...
Purpose.Examine effects of a Medicaid family planning waiver on the receipt reproductive health care and pregnancy.Design.The present study uses quasiexperimental design using data from California Women's Health Survey Behavioral Risk Factor Surveillance System (BRFSS) for exposure comparison groups, before after California's Planning Access Care Treatment waiver.Setting.The setting was states.Subjects.The included women who were ages 18 to 44 years below 200% federal poverty level (FPL),...
Effects of Medicaid family planning waivers on unintended births and contraceptive use postpartum were examined in Illinois, New York, Oregon using the Pregnancy Risk Assessment Monitoring System. Estimates for women who would be eligible "if" pregnant waiver states without expansions derived a difference-in-differences approach. Waivers York Illinois associated with almost 5.0 percentage point reduction unwanted among adults 7 to 8.0 reduction, youth less than 21 years age. Oregon's was an...
Abstract Background Malaria programmes in countries with low transmission levels require evidence to optimize deployment of current and new tools reach elimination limited resources. Recent pilots strategies Ethiopia, Senegal, Zambia produced their epidemiological impacts costs. There is a need generalize these findings different health systems contexts. Methods Drawing on experience implementing partners, operational documents costing studies from pilots, reference scenarios were defined...
Objectives Current guidelines for the control of soil-transmitted helminths (STH) recommend deworming children and other high-risk groups, primarily using school-based (SBD) programmes. However, targeting individuals all ages through community-wide mass drug administration (cMDA) may interrupt STH transmission in some settings. We compared costs cMDA to SBD inform decision-making about future updates policy. Design conducted activity-based microcosting 2 years Benin, India Malawi within an...
Abstract Background Rectal artesunate (RAS), an efficacious pre-referral treatment for severe malaria in children, was deployed at scale Uganda, Nigeria and DR Congo. In addition to distributing RAS, implementation required additional investments crucial but neglected components the care malaria. We examined real-world costs barriers RAS implementation. Methods collected primary data on baseline health system gaps subsequent expenditures. calculated equivalent annual cost of per child under...
Background Patients with hormone receptor-positive, HER2-negative breast cancer who have residual invasive disease after neoadjuvant chemotherapy (NACT) are at a high risk of relapse. PENELOPE-B was double-blind, placebo-controlled, phase III trial that investigated adding palbociclib (PAL) for thirteen 28-day cycles to adjuvant endocrine therapy (ET) in these patients. Clinical results showed no significant improvement disease-free survival PAL. Methods We performed pre-planned...
Objective To present a costing study integrated within the DeWorm3 multi-country field trial of community-wide mass drug administration (cMDA) for elimination soil-transmitted helminths. Design Tailored data collection instruments covering resource use, expenditure and operational details were developed each site. These populated alongside activities by on-site staff. Data quality control validation processes established. Programmed routines used to clean, standardise analyse derive costs...
Background RTS,S is a malaria vaccine directed at the pre-erythrocytic stage of Plasmodium falciparum ,a nd currently in late-stage Phase III clinical trials multiple sites across Africa. Modeling and simulation have been used to predict public health impact (PHI) but previous exercises had access limited trial data did not provide country-specific results. PHI sensitive many assumptions including profile underlying country specific inputs. Materials methods We simulated numbers cases deaths...
Background Scale-up of malaria preventative and control interventions over the last decade resulted in substantial declines mortality morbidity disease. Sustaining these gains future will depend on health system performance. Treatment provides individual benefits by curing infection preventing progression to severe disease as well community-level reducing infectious reservoir averting emergence spread drug resistance. However many patients with do not access care, providers always comply...
Background Malaria disease shifts to older ages when interventions are applied only the youngest children, and incidence will resurge in endemic settings intervention coverage decreases. This has consequences for deployment of long-lasting insecticide treated nets or infection blocking vaccines (e.g. pre-erythrocytic vaccines). These delay acquisition immunity, with result that previously protected individuals may experience pathology later life due undeveloped waning immunity. Here we use a...