A5061784604- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Malaria Research and Control
- Bacterial Infections and Vaccines
- Pneumonia and Respiratory Infections
- Influenza Virus Research Studies
- Viral gastroenteritis research and epidemiology
- Vector-borne infectious diseases
- Viral Infections and Outbreaks Research
- Virology and Viral Diseases
- Vector-Borne Animal Diseases
- Monoclonal and Polyclonal Antibodies Research
- Respiratory viral infections research
- Vaccine Coverage and Hesitancy
- Zoonotic diseases and public health
- Hepatitis Viruses Studies and Epidemiology
- Global Maternal and Child Health
- Viral Infections and Immunology Research
- Bird parasitology and diseases
- Data-Driven Disease Surveillance
- Smoking Behavior and Cessation
- Pediatric Pain Management Techniques
- Dengue and Mosquito Control Research
- Peptidase Inhibition and Analysis
- Metabolism and Genetic Disorders
Program for Appropriate Technology in Health
2016-2024
Seattle University
2016-2023
Rajshahi Medical College
2023
Chittagong Medical College
2023
Dinajpur Medical College
2023
Rangpur Medical College
2023
Institute of Epidemiology, Disease Control and Research
2023
Centers for Disease Control and Prevention
1993-2020
Royal Centre for Disease Control
2020
International Vaccine Institute
2009-2014
Dengue fever is a virus infection that spread by the Aedes aegypti mosquito and can cause severe disease especially in children. major problem tropical sub-tropical regions of world.We invited dengue experts from around world to attend meetings discuss surveillance. We reviewed literature, heard detailed reports on surveillance programs, shared expert opinions.Presentations 22 countries were during 2.5 day meetings. describe best methods general, stakeholders surveillance, steps bite...
The prevention of invasive Haemophilus influenzae type b disease requires a vaccine that is effective when administered during the first six months life. infants Alaska Natives are at particularly high risk H. disease.
Enterotoxigenic Bacteroides fragilis was isolated from stool specimens of 8 44 diarrheic individuals (ages, 4 months to 69 years). The had watery diarrhea and intestinal cramping; infants hyperthermia, vomiting, blood in the stools. No recognized enteric pathogens were detected seven eight positive for enterotoxigenic B. fragilis. bacterium produced an enterotoxin detectable concentrated broth that supported bacterial growth. Fifteen adult rabbits with ligated ceca developed fatal disease...
Vaccines against Japanese encephalitis (JE) have been available for decades. Currently, most JE-endemic countries vaccination programs their at-risk populations. Even so, JE remains the leading recognized cause of viral in Asia. In 2018, U.S. Centers Disease Control and Prevention PATH co-convened a group independent experts to review prevention control successes, identify remaining scientific operational issues that need be addressed, discuss opportunities further strengthen programs,...
To determine whether yellow fever (YF) vaccine administered in pregnancy causes fetal infection, women who were vaccinated during unrecognized a mass campaign Trinidad studied retrospectively. Maternal and cord or infant blood tested for IgM neutralizing antibodies to YF dengue viruses. One of 41 infants had elevated virus, indicating congenital infection. The infant, the first reported case virus infection after immunization pregnancy, was delivered an uncomplicated full-term appeared...
Background Dengue vaccines are now in late-stage development, and evaluation robust estimates of dengue disease burden needed to facilitate further development introduction. In Cambodia, the national case-definition only allows reporting children less than 16 years age, little is known about rural areas among older persons. To estimate true largest province Kampong Cham, we conducted community-based active fever surveillance 0-to-19–year age group villages urban during 2006–2008. Methods...
Background Disease incidence data are needed to guide decision-making for public health interventions. Although dengue is a reportable disease in Thailand and Cambodia, the degree that reported underrecognizes true burden unknown. We utilized calculated from laboratory-confirmed outpatient inpatient cases prospective cohort studies estimate magnitude of underrecognition establish more accurate estimates these countries. Methods Findings Cohort were conducted among children aged <15 years by...
Background There is an urgent need to field test dengue vaccines determine their role in the control of disease. Our aims were study epidemiology and prepare site for a vaccine efficacy trial. Methods Findings We performed prospective cohort children primary schools central Thailand from 2006 through 2009. assessed by active fever surveillance acute febrile illness as detected school absenteeism telephone contact parents, diagnostic testing. Dengue accounted 394 (6.74%) 5,842 cases...
Adouble-blind, randomized, placebo-controlled trial was conducted to evaluate the safety and efficacy of a rhesus rotavirus vaccine RIT 4237, bovine vaccine, in Navajo population. Infants aged 2–5 months were randomized receive one dose either 104 pfu or 108 4237 placebo. Eleven (10.2%) infants group, 11 (10.4%) 106 9 (8.4%) 107 placebo group experienced diarrhea during follow-up period 17 months. Thus, this population, neither efficacious preventing diarrhea.
We compared the immunogenicity of four available Haemophilus influenzae type b (Hib) conjugate vaccines in Alaska Native infants. Three vaccines, Hib oligosaccharide-CRM197 (HbOC), polyribosylribitol phosphate-diphtheria toxoid (PRP-D) and phosphate-tetanus (PRP-T), were given at 2, 4 6 months age, PRP Neisseria meningitidis outer membrane protein (PRP-OMP) vaccine was 2 age. Enrollment largely sequential by availability beginning with HbOC ending PRP-T. A total 225 infants completed full...
Abstract The number of cases and severity disease associated with dengue infection in Sri Lanka has been increasing since 1989, when the first epidemic hemorrhagic fever was recorded. We identified a new virus 1 strain circulating that coincided 2009 epidemic.
Background Dengue infection is one of the most important mosquito-borne diseases. More data regarding disease burden and prevalence each clinical spectrum among symptomatic infections manifestations are needed. This study aims to describe incidence dengue in Thai children during 2006 through 2008. Study Design a school-based prospective open cohort with 9,448 person-year follow-up aged 3–14 years. Active surveillance for febrile illnesses was done studied subjects. Subjects who had illness...
SUMMARY Robust disease burden estimates are important for decision-making concerning introduction of new vaccines. Dengue is a major public health problem in the tropics but robust lacking. We conducted two-sample, capture–recapture study largest province Cambodia to determine under-recognition National Surveillance System (NDSS). During 2006–2008, community-based active surveillance acute febrile illness was 0- 19-year-olds rural and urban areas combined with testing dengue virus infection....
We analyzed surveillance data of a dengue outbreak (2010) reported to the Hadramout Health Office (Yemen) and retrospectively dengue-related epidemiological entomological events in from 2005 2009. A total 630 immunoglobulin M (IgM) -confirmed cases 982 febrile was during period February June 2010; 12 died, giving case fatality rate 1.9%. Among cases, highest proportion (37.3%) 15- 24-year-old age group. The overall attack 0.89/1,000. average number by month over preceding 5-year compared...
Dengue is the most significant arthropod-borne viral infection of humans. Persons infected with dengue viruses (DENV) have subclinical or clinically apparent infections ranging from undifferentiated fever to hemorrhagic fever/shock syndrome. Although recent studies estimated that Indian subcontinent has greatest burden DENV and disease worldwide, we do not reliable, population-based estimates incidence in this region. The goal study was follow-up a cohort 800 children living heavily...
Maternal smoking during pregnancy may decrease breastfeeding, in part perhaps by decreasing milk supply; furthermore, prenatal is a predictor of postpartum smoking. In this study, birth certificate data, including maternal smoking, for 1998 Oregon resident live births were linked to newborn screening data obtained from Oregon's Newborn Screening Program (NSP), allowing study risk factors failure breastfeed. NSP collects information on infant feeding before discharge and again at about 2...
Prospective surveillance of Haemophilus influenzae type b (Hib) disease has been done since 1981 in two high-risk populations, White Mountain Apaches and Navajos. The attack rate children less than 5 years age is 5-10 times higher the general US population. Three vaccines were evaluated. Unconjugated Hib capsular polysaccharide produced lower antibody responses 18- 24-month-old Apache infants white infants. HbOC (Hib oligosaccharide covalently linked to nontoxic mutant diphtheria toxin...
A dengue fever surveillance study was conducted at three medical facilities located in the low-income district of San Javier Medellin, Colombia. During March 2008 to 2009, 781 patients with regardless chief complaint were recruited for acute virus infection testing. Of tested, 73 (9.3%) positive infection. Serotypes DENV-2 (77%) and -3 (23%) detected by PCR. One patient met diagnostic criteria hemorrhagic fever. Only 3 out (4.1%) febrile subjects testing diagnosed treating physician. This...
An Eastern equine encephalitis (EEE) outbreak in 1989 led to nine human and 196 cases, chiefly coastal Atlantic Gulf Coast counties. In the past two decades, EEE age-specific incidence mortality rates have declined compared with earlier years. Analysis of rainfall patterns areas where cases occurred between 1983 revealed an association occurrence excess rainfall. The was stronger data from local weather stations than statewide averages predictive models were best when applied northern...
In a high risk Navajo population we compared the immunogenicity of new Haemophilus influenzae type b mutant-diphtheria toxic conjugate vaccine (HbOC) with simultaneous active and passive immunization bacterial polysaccharide immunoglobulin prepared from adults immunized H. b, pneumococcal meningococcal vaccines Only 7 26 (27%) 2-month-olds had an increase in capsular antibody after single dose HbOC, proportion similar to that saline controls (9 25, 36%). After second HbOC at 4 months 88%...
Disease caused by Neisseria meningitidis occurs in the United States population with an incidence of 0.6 to 1.3/100 000 depending on serotype (∼2600 cases annually). Case fatality is 12% 45% annually reported Group C organisms. Outbreaks Serogroup meningococcal disease have occurred increasing frequency recent past.1 Asymptomatic carriage general at any given time from 5 10%.2 meningococcus a for which polysaccharide vaccine efficacious persons older than 2 years3 and considered useful tool...