A5069109896- Dental Implant Techniques and Outcomes
- Periodontal Regeneration and Treatments
- Bone Tissue Engineering Materials
- Dental Radiography and Imaging
- Oral microbiology and periodontitis research
- Dental materials and restorations
- dental development and anomalies
- Orthopaedic implants and arthroplasty
- Orthodontics and Dentofacial Orthopedics
- Oral and gingival health research
- Reconstructive Surgery and Microvascular Techniques
- Oral Health Pathology and Treatment
- Cleft Lip and Palate Research
- Surgical Sutures and Adhesives
- Streptococcal Infections and Treatments
- Temporomandibular Joint Disorders
- HIV/AIDS oral health manifestations
- Oral health in cancer treatment
- 3D Printing in Biomedical Research
- Oral and Maxillofacial Pathology
- Natural product bioactivities and synthesis
- Collagen: Extraction and Characterization
- Electrospun Nanofibers in Biomedical Applications
- Gut microbiota and health
- Dental Trauma and Treatments
Yonsei University College of Dentistry
2016-2025
Yonsei University
2016-2025
Harvard University
2025
Yonsei University Dental Hospital
2021-2024
Government of the Republic of Korea
2023
Universidad Complutense de Madrid
2017-2018
National Research Foundation of Korea
2013
Hallym University
1997
The purpose of this study was to determine the clinical, microbial, and radiographic effects local minocycline combined with surgical treatment peri-implantitis. Fifty patients peri-implantitis were recruited, application either or placebo ointment performed. repeated supragingival debridement at 1, 3, 6 mo postoperatively. Plaque index, gingival index (GI), probing pocket depth (PPD), bleeding/suppuration on measured baseline 1-, 3-, 6-mo evaluations. change in supporting bone level (SBL)...
To test whether or not alveolar ridge preservation reduces vertical changes in the posterior maxilla compared to spontaneous healing following tooth extraction.Forty subjects requiring extraction of maxillary teeth with root apices protruding into sinus floor were consecutively enrolled. Patients randomly assigned either one two surgical interventions: an procedure using collagenated bovine bone mineral and a resorbable collagen membrane (test) no grafting (control). Cone-beam computed...
To evaluate in vitro the changes implant surface topography and roughness of commercial implants after instrumentation with five decontamination protocols.Seventy-two titanium a sandblasted acid-etched (SLA) were placed 5 mm supra-crestally. Five groups twelve instrumented following protocols: metal scaler tip (SCAL), thermoplastic (PEEK), round brush (RBRU), tufted bristles (TNBRU), glycine-based air-powder abrasive (GLYC). A sixth group untreated was used as control. Scanning electron...
Abstract Aim To test whether soft‐type block bone substitute used for guided regeneration (GBR) of peri‐implant defects leads to a different dimension the augmented hard tissue than particulate substitute. Materials and Methods In 40 patients, two‐piece dental implants were placed >2 months after tooth extraction. Following random allocation, 20 dehiscences grafted with made synthetic biphasic calcium phosphate (BCP) + collagen BCP. All sites covered membrane stabilized titanium pins....
Abstract Defect‐specific bone regeneration using 3‐dimensional (3D) printing of block has been developed. Polycaprolactone (PCL) is biocompatible polymer that can be used as 3D scaffold. The aim this study to assess the biocompatibility and osteogenic efficacy printed PCL scaffold evaluate effectiveness β‐tricalcium phosphate (β‐TCP) addition in In work, four circular defects (diameter: 8 mm) rabbit calvarium were randomly assigned (1) negative control (control), (2) (PCL), (3) mixed with 10...
Abstract Backgrounds Clinical benefits in bone grafting of intact extraction socket have been widely known, but limited evidence is available for the procedure damaged sockets due to periodontal disease. Purpose This study aimed determine dimensional alteration alveolar ridge following sockets, and compare outcomes using deproteinized bovine (DBBM) versus porcine mineral (DPBM) sockets. Materials Methods One hundred patients ( n = 50 each group) with periodontitis‐induced were included this...
ABSTRACT Aim To compare the dimensional stability of a self‐retaining synthetic block bone (srBB) and particles (SBP) for alveolar ridge augmentation (ARA) in damaged extraction sockets. Materials Methods ARA was randomly performed two centres on 57 participants presenting socket non‐molar tooth: (i) srBB collagen membrane (srBB group, n = 29) or (ii) SBP (SBP 28). Cone beam computed tomography (CBCT) immediately after ARP (baseline, T0) at 6 months (T1). T0 T1 CBCTs were superimposed,...
Proteolysis-targeting chimeras (PROTACs) degrade target proteins through the ubiquitin-proteasome system. To date, PROTACs are primarily used to treat various diseases; however, they have not been applied in regenerative therapy. Herein, this work introduces MDM2-targeting customized for application bone regeneration. An MDM2-PROTAC library is constructed by combining Nutlin-3 and CRBN ligands with linker designs. Through a multistep validation process, develops MDM2-PROTACs (CL144 CL174)...
Abstract Purpose The objective of this study was to determine the effectiveness collagenated biphasic calcium phosphate ( CBCP ) as a carrier for bone morphogenetic protein‐2 BMP ‐2) at early stage healing in rabbit sinus. Material and Methods In 16 rabbits, ‐2‐loaded grafted into one sinus (the group) saline‐soaked another CTL group). groups were assigned randomly. After 2 weeks n = 8) or 4 8), radiographic histological analysis performed. Results Total augmented volume significantly larger...
Biphasic calcium phosphate (BCP) is the most frequently used synthetic bone substitutes, which comprises a combination of hydroxyapatite (HA) and beta-tricalcium (b-TCP). Thanks to recent advances in digital dentistry three-dimensional (3D) printing technology, block substitutes can be customized fit individual defect morphologies. The diameter pores influence rate formation material resorption. aim this study was compare three-dimensionally printed biphasic with different pore diameters...
Abstract Aim The objective of this study was to determine the efficacy bone morphogenetic protein 2 ( BMP ‐2) in a bovine hydroxyapatite/collagen BHC ) carrier augment formation canine nasal sinus model. Methods Eight mongrel dogs, approximately 12 months old and 30 kg weight were used. Following preparation bilateral access windows, alone (control) or loaded with E. coli ‐derived BMP‐2 at 0.1 mg/ml implanted four animals, 0.5 1.5 animals. animals euthanized 20 weeks when block sections...
This study histologically analyzed biopsy samples obtained from sites of damaged extraction socket grafting using deproteinized bovine bone mineral (DBBM) or porcine (DPBM) with coverage by a collagen membrane.One hundred patients participated in this randomized controlled clinical trial grafts performed cases periodontally compromised teeth. All participants were blinded to their group allocations, and each material was grafted membranes after the tooth removal granulation tissue. At...
Clinical benefits of local antibiotics as an adjunct to nonsurgical treatment peri-implantitis have been widely reported, but most studies evaluated incipient lesions, and showed incomplete success rates.To assess the clinical microbiological outcomes administering metronidazole in combination with minocycline a peri-implantitis.One hundred eighteen subjects were recruited four-center, three-arm, 12-week randomized controlled trial. Subjects randomly assigned receive one following...
Guided bone regeneration aided by the application of occlusive membranes is a promising therapy for diverse inflammatory periodontal diseases. Symbiosis, homeostasis between host microbiome and cells, occurs in oral environment under normal, but not pathologic, conditions. Here, we develop symbiotically integrating membrane mimicking tooth enamel growth or multiple nucleation biomineralization processes. We perform human saliva vivo canine experiments to confirm that induces symbiotic...
Abstract This retrospective study aimed to determine risk factors associated with post-operative bleeding after dentoalveolar surgery in patients taking anticoagulants. Patients anticoagulants who were planned undergo periodontal flap operation, tooth extraction or implant included. divided into two subgroups according the maintenance of following medical consultation: (1) group and (2) discontinuation group. The analysed patient-related included systemic diseases, types anticoagulant....
The use of appropriate instruments to clean surfaces with minimal change, is critical for the successful maintenance a dental implant. However, there no consensus about type and methodology such instruments. aim this study was characterize changes in roughness titanium treated by various scaling Thirty-seven identical disks (5 mm diameter) were investigated study. specimens divided into eight groups according types instrumentation angle application. Ultrasonic systems applied on disk...
Objectives This study histologically evaluated the influence of cortical perforation grafted autogenous block bone (ABB) and/or recipient bed at different healing periods in dogs. Material and methods Four ABBs harvested from posterior mandible were bilaterally fixed onto maxillary premolar region five mongrel The experiments involved four groups according to site: ABB bed. animals killed 1, 4, 10 days (early periods) 4 8 weeks (late postoperatively. Specimens prepared for histological...
This study evaluated histologically the tissue responses to and effects of a customized nano-hydroxyapatite (n-HA) block bone graft on periodontal regeneration in one-wall periodontal-defect model. A for filling standardized defect was fabricated from prefabricated n-HA powders polymeric sponge. Bilateral 4×4×5 mm (buccolingual width×mesiodistal width×depth), one-wall, critical-size intrabony defects were surgically created at mandibular second fourth premolars five Beagle dogs. In each dog,...
The aim of the present study was to evaluate physiochemical properties and resorption progress two cross-linked, porcine skin-derived collagen membranes compare their features with those a membrane without cross-linking (Bio-Gide® [BG], Geistlich Biomaterials, Wolhusen, Switzerland). Three membranes, dehydrothermally (DHT) cross-linked (experimental), DHT 1-ethyl-3(3-dimethylaminopropyl)-carbodiimide (DHT/EDC) (experimental) BG were investigated for morphology, enzyme resistance, tensile...