A5005972846- Pharmacogenetics and Drug Metabolism
- Pharmacological Effects of Natural Compounds
- Drug Transport and Resistance Mechanisms
- Control Systems and Identification
- Quinazolinone synthesis and applications
- Berberine and alkaloids research
- Phenothiazines and Benzothiazines Synthesis and Activities
- Chemical synthesis and alkaloids
- Lymphoma Diagnosis and Treatment
- RNA Interference and Gene Delivery
- Cancer Genomics and Diagnostics
- Environmental DNA in Biodiversity Studies
- Mathematical Biology Tumor Growth
- DNA and Nucleic Acid Chemistry
- Metabolomics and Mass Spectrometry Studies
- Advanced biosensing and bioanalysis techniques
- Ocular Diseases and Behçet’s Syndrome
- Mathematical and Theoretical Epidemiology and Ecology Models
- Immune cells in cancer
- Food Supply Chain Traceability
- Evolution and Genetic Dynamics
- Viral-associated cancers and disorders
- Extracellular vesicles in disease
- Fault Detection and Control Systems
- Plant and Biological Electrophysiology Studies
Tianjin University of Traditional Chinese Medicine
2019-2023
Tianjin haihe hospital
2022
Tianjin Medical University Cancer Institute and Hospital
2021
Sichuan University
2010-2021
Zhejiang Sci-Tech University
2021
Southwest University
2019
Shandong University of Traditional Chinese Medicine
2019
Affiliated Hospital of Shandong University of Traditional Chinese Medicine
2019
ORCID
2019
Hohai University
2019
MicroRNAs (miRNAs) are useful biomarkers for the diagnosis of a variety cancers. However, it is major challenge to detect miRNAs, considering their high sequence similarity, low concentration, and small size nature. With establishment an efficient rolling circle amplification (RCA) molecular network by target-driven polymerization/nicking reactions, we present here exponential strategy detecting miRNA in label-free way with ultrahigh sensitivity. The target sequences can bind two ssDNA...
Berberrubine (BRB), an isoquinoline alkaloid, is a major constituent of medicinal plants Coptis chinensis Franch or Phellodendron chinense Schneid. BRB exhibits various pharmacological activities, whereas exposure to may cause toxicity in experimental animals.In this study, we thoroughly investigated the liver injury induced by mice and rats. To explore underlying mechanism, study metabolic activation was conducted. Furthermore, covalent modifications cysteine residues proteins were observed...
Precision livestock management requires animal traceability and disease trajectory, for which discriminating between or re-identifying individual animals is of significant importance. Existing re-identification (re-ID) methods are mostly proposed persons vehicles, compared with extraordinarily more challenging to be re-identified because subtle visual differences individuals. In this paper, we focus on image-based re-ID yaks (Bos grunniens), indispensable in local husbandry economy...
Objective of this paper is to excavate the siderophore synthesis gene from Brevibacillus brevis GZDF3 and verify its type antibacterial effects. The method using genome mining technology analyze genes phylogenetic tree each was constructed separately. Iron free medium utilized induce CAS liquid detection used for qualitative quantitative analysis on siderophore. preliminaries identified by Arnow effects were analyzed according agar punching method. results show that a cluster with 83%...
This article has been retracted by the publisher.
This paper introduces a robust identification solution for the linear parameter varying Autoregressive Exogenous systems with outlier-contaminated outputs. The Laplace distribution heavy tails and expectation maximization algorithm are combined to build system framework. To overcome obstacles brought by outliers, which can be decomposed into infinite Gaussian components, is applied mathematically model noise. problem of estimation solved using algorithm, equations infer noise parameters...
Background: Based on the conserved sequences of a known NBS resistance gene, pair degenerate primers was designed to amplify NBS-LRR gene from peanut using PCR and RACE methods.Results: Analyzing amino acid sequence by BLAST NCBI, which deduced 1088bp-long named PnAG1-2, showed that it had certain homology with some proteins, among Arachis cardenasii protein highest (66%).Relative quantification analysis indicated PnAG1-2 expresses more in J11 (an A. flavus-resistant variety) than JH1012...
Objective To explore the current status of nursing work process in Tianjin Third Grade A General Hospital, to interpret available space human resources, and find new ideas for configuration optimization. Methods According industrial engineering theory program analysis method, combined with characteristics professional, define name activity, build evaluation index formula level, workday practice method was used investigate analyze nurses′ processes a total 48 departments four hospitals...
Electronic health record is an important part of medical information research and has been widely used in institutions to help personnel deal with various information. However, due the lack standardized nursing language, nurses are often unable reuse data electronic records, which hinders further development sharing records. The use language can support efficient complete documents records meet requirements clinical interoperability. This paper summarizes definition significance application...
Abstract Background/purpose Cancer immunotherapy has revolutionized the clinical treatment of several tumors. Immune infiltration been found to be closely related prognosis, but it shows limited activity in breast cancer (BC). Therefore, this study aimed explore pattern immune cells BC, and find potential prognostic markers new therapeutic targets.Patients methods We downloaded genome data BC from Genome Atlas (TCGA), analyzed tumor- infiltrating (TIICs) for first time using CIBERSORT...
Linderane (LDR), the main active and distinctive component of L. aggregate, is a mechanism-based inactivator CYP2C9 in vitro, indicating occurrence herb-drug interactions. However, little known about changes pharmacokinetic properties common clinical drugs as substrates after coadministration with LDR. In this study, selective rapid ultraperformance liquid chromatography-tandem mass spectrometry (UPLC-MS-MS) method for determination diclofenac, tolbutamide, warfarin rat plasma has been...
Abstract Background Berberidis Radix (Sankezhen), a typical multi-origin Chinese medicinal material, originates from the dried roots of Berberis genus plants. Previous studies have shown that there were significant differences in chemical compositions different species. Therefore, it was exceedingly important to accurately identify species . Results In this study, for first time, we systematically compared complete chloroplast genome sequences six ( B. julianae , tsienii pruinose thunbergii...
Peptides are a class of protein fragments with relatively high biological activity, strong specificity. Some them have stimulated considerable interest because their unique advantages in many diseases. Modern studies shown that multiple anticoagulant play crucial role Shuxuetong injection (SXT). However, the extraordinary complexity Chinese medicinal formulate and lack identification method primary challenges for ingredients. In addition, infinitesimal peptides contents further hinder...