A5041650666- Orthopaedic implants and arthroplasty
- Total Knee Arthroplasty Outcomes
- Orthopedic Infections and Treatments
- Hip disorders and treatments
- Bone Tissue Engineering Materials
- Cancer-related gene regulation
- Osteoarthritis Treatment and Mechanisms
- RNA modifications and cancer
- Bone Metabolism and Diseases
- Bone health and osteoporosis research
- Epigenetics and DNA Methylation
- Knee injuries and reconstruction techniques
- Lung Cancer Treatments and Mutations
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Bone fractures and treatments
- Cell Adhesion Molecules Research
- Cellular Mechanics and Interactions
- RNA Interference and Gene Delivery
- Pelvic and Acetabular Injuries
- Bone health and treatments
- Proteoglycans and glycosaminoglycans research
- Inflammatory mediators and NSAID effects
- Periodontal Regeneration and Treatments
- Hip and Femur Fractures
Shanghai Jiao Tong University
2016-2025
Shanghai Ninth People's Hospital
2016-2025
Yue Bei People's Hospital
2019-2023
Shantou University
2019-2023
Institute of Laboratory Animal Science
2021-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2023
Research Medical Center
2023
Xinjiang Medical University
2010-2022
Ministry of Health of the Russian Federation
2021
State Administration of Traditional Chinese Medicine of the People's Republic of China
2021
Osteoarthritis (OA) is a degenerative joint disease with an immense unmet medical need. FGF18 protein potential regenerative factor for cartilage repair. However, traditional delivery methods have limited efficacy due to the short lifetime and shallow infiltration. In this work, we discovered that lipid nanoparticle (LNP) can infiltrate deliver mRNA deeper in than proteins. After UTR optimization chemical modification, expression of last up 6 days cartilage. Furthermore, delivering activates...
The purpose of this hospital-based case-control study was to evaluate the risk factors for periprosthetic joint infection (PJI) total hip arthroplasty (THA) and knee (TKA) in Chinese patients.From January 2000 December 2012, 45 patients undergoing THA TKA who developed PJI were recruited case subjects; controls 252 without PJI, matched by year index surgery type surgery. Conditional logistic regressions run compute odds ratios (ORs) 95% confidence intervals (CIs).Demographic comorbid...
Revision THA is particularly challenging in hips with severe acetabular bone loss. When the extent or geometry of loss precludes more-straightforward techniques such as jumbo hemispheric cementless shells, reconstruction morselized allograft protected by a custom cage may offer an alternative, but, to our knowledge, few series have reported on results this approach.For patients (Paprosky IIIB) defects, we asked: do individualized cages result (1) improved Harris hip scores; (2) restoration...
Surgical masks (SMs) are used to reduce bacterial shedding from the mouth, nose and face. This study aimed investigate whether SMs may be a potential source of leading an increased risk surgical site infection. Bacterial contamination was tested by making impression external surface mask on sterile culture media immediately. We investigated difference in counts between worn surgeons those placed unused operating room (OR), count variation with indicated wearing time. Moreover, first second...
Tensile load is known to regulate the osteogenesis of mesenchymal stem cells (MSCs) and osteogenic progenitors; therefore it widely used in clinical treatment tissue engineering. Meanwhile, vitro, both published studies our lab data demonstrate that application intermittent tensile loading which stimulates several minutes or hours each day for days has promoted differentiation MSCs. Whereas, clinic trails, important know accurately how long mechanical tension should be applied. Hence,...
Abstract Background Essential hypertension (EH) is a complex disease as consequence of interaction between environmental factors and genetic background, but the pathogenesis EH remains elusive. The emerging tools network medicine offer platform to explore at system level. In this study, we aimed identify key proteins biological regulatory pathways involving in further molecular connectivities these by topological analysis Protein-protein (PPI) network. Result extended including one giant...
Osteoarthritis (OA) is the most common degenerative disease of synovial joint. The membrane responsible for inflammatory reaction leading to secretion macrophage-derived pro-inflammatory cytokines, such as IL-6. Suppressing IL-6 over-expression in fibroblasts (SF) a promising method prevent OA development and progression, which prerequisite elucidation molecular mechanisms underlying SF. Currently, there are few reports concerning epigenetic modifications In present study, we attempted...
Atopic dermatitis (AD) is the most common skin disorder in infancy. However, diagnosis and definite significance of infantile AD remains a debated issue.To analyse phenotypes infancy, to establish diagnostic criteria estimate prevalence this condition China.This multicentric study, which 12 locations were chosen from different metropolitan areas China. Following careful complete history-taking examination, was made severity based on SCORAD index determined by local experienced...
Abstract Purpose Swelling in the lower limbs after total knee arthroplasty (TKA) affects surgical outcomes. Prolonged swelling requires monitoring and remote management during home-based rehabilitation. Causes of vary but, so far, no indicators are available to monitor identify causes limb swelling, making it difficult implement targeted interventions. This study aimed find rehabilitation TKA by literature research consulting experts from various disciplines. Methods The Delphi method was...
Sagittal lumbar pelvic alignment alters with posterior tilt (PT) following total hip arthroplasty (THA) for developmental dysplasia of the (DDH). The individual value sagittal inclination (PSI) rebalancing lumbar-pelvic is unknown. In different populations, PT regresses in a linear relationship incidence (PI). PSI and have direct to each other via fixed angle ∠γ. This study aimed investigate whether new PI created by acetabular component positioning during THA also has regression PT/PSI when...
The objective of this study was to investigate the mechanism by which insulin-like growth factor 2 mRNA-binding protein (IGF2BP2) interacts with downstream target genes influence progression triple-negative breast cancer (TNBC). involved a total 80 tissue samples collected from various types tumors and benign tumors. gene expression levels IGF2BP2 in were quantified using real-time quantitative reverse transcription PCR (qRT-PCR). abilities cell proliferation, apoptosis, migration, invasion...