A5075286475- Gastric Cancer Management and Outcomes
- Colorectal Cancer Surgical Treatments
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Colorectal and Anal Carcinomas
- Colorectal Cancer Screening and Detection
- Peptidase Inhibition and Analysis
- Pancreatic and Hepatic Oncology Research
- Immune Cell Function and Interaction
- Metastasis and carcinoma case studies
- MicroRNA in disease regulation
- Immunotherapy and Immune Responses
- Nanoplatforms for cancer theranostics
- T-cell and B-cell Immunology
- Colorectal Cancer Treatments and Studies
- Gastrointestinal Tumor Research and Treatment
- Mycobacterium research and diagnosis
- Gastrointestinal disorders and treatments
- Esophageal and GI Pathology
- Nanoparticle-Based Drug Delivery
- Ferroptosis and cancer prognosis
- Hernia repair and management
- Hepatocellular Carcinoma Treatment and Prognosis
- Aquaculture Nutrition and Growth
- Immune Response and Inflammation
Xinjiang Medical University
2010-2025
Tumor Hospital of Xinjiang Medical University
2025
Murdoch University
2025
Dalian University of Technology
2024
Liaoning Cancer Hospital & Institute
2018-2024
China Medical University
2015-2024
Yinchuan First People's Hospital
2019-2024
Ningxia Medical University
2019-2024
Second Affiliated Hospital of Xinjiang Medical University
2024
Xian Yang Central Hospital
2024
The blood-brain barrier (BBB) is the main bottleneck to prevent some macromolecular substance entering cerebral circulation, resulting failure of chemotherapy in treatment glioma. Cancer nanotechnology displays potent applications glioma therapy owing their penetration across BBB and accumulation into tumor core. In this study, we have tailored particle size mesoporous silica nanoparticles (MSNs) through controlling hydrolysis rate polycondensation degree reactants, optimized nanosystem that...
Abstract Nanorod‐based drug delivery systems have attracted great interest because of their enhanced cell internalization capacity and improved loading property. Herein, novel mesoporous silica nanorods (MSNRs) with different lengths are synthesized used as nanocarriers to achieve higher anticancer activity. As expected, MSNRs‐based can effectively enhance the drugs penetrate into tumor cells more rapidly than spherical nanoparticles due greater surface area trans‐membrane transporting...
N6-methyladenosine (m 6 A) is a common form of mRNA modification regulated by m6A RNA methylation regulators and play an important role in the progression gastric cancer (GC). However, prognostic m A-related lncRNA has not been fully explored. This study aims at exploring biological function roles signature cancer. A total 800 m6A-related lncRNAs were identified through Pearson correlation analysis between all lncRNAs. Eleven signatures survival Kaplan-Meier (KM) curve results suggest that...
T cell immunoglobulin and ITIM domain (TIGIT) is a recently identified coinhibitory receptor. Studies have shown that TIGIT expressed in colon adenocarcinoma, uterine corpus endometrioid carcinoma, breast carcinoma kidney renal clear carcinoma. However, the role of TIGIT/human poliovirus receptor (CD155) pathway pathogenesis hepatocellular (HCC) remains to be elucidated. In present study, expression CD155 HCC tissues peripheral blood were determined, correlations among TIGIT, CD155, TIGIT+...
Gallium(III)-based drugs have gained momentum in cancer therapy due to their iron-dependent anticancer activity. Judicious choice of ligands is critical for improved oral bioavailability, antitumor efficacy, and distinct mechanisms from simple GaIII salts. We describe complexes with planar tetradentate salen [salen=2,3-bis[(4-dialkylamino-2-hydroxybenzylidene)amino]but-2-enedinitrile)] labile axial solvent ligands, which display tumor growth inhibition vitro vivo comparable cisplatin....
Objective EVA1B, a protein coding gene, is critical paralog of EVA1A gene. Herein, our study was conducted to investigate the role EVA1B in colorectal cancer (CRC) progression and prognosis. Methods Pan-cancer analysis analyze expression, genetic epigenetic alterations, immunological characteristics EVA1B. Especially, mutational landscape were compared between high low expression groups combined TCGA-COAD TCGA-READ datasets. Through random survival forest analysis, an EVA1B-derived genomic...
The objective of this study was to investigate the mechanism by which insulin-like growth factor 2 mRNA-binding protein (IGF2BP2) interacts with downstream target genes influence progression triple-negative breast cancer (TNBC). involved a total 80 tissue samples collected from various types tumors and benign tumors. gene expression levels IGF2BP2 in were quantified using real-time quantitative reverse transcription PCR (qRT-PCR). abilities cell proliferation, apoptosis, migration, invasion...
Nanomaterials-based drug delivery systems display potent applications in cancer therapy, owing to the enhanced permeability and retention effect diversified chemical modification. In this study, we have tailored synthesized different sized mesoporous silica nanoparticles (MSNs) through reactant control investigate relevancy of nanoparticle size toward anticancer efficacy suppressing multidrug resistance. The MSNs loaded with ruthenium complex (RuPOP) conjugated folate acid (FA) enhance...
Gastric cancer (GC) remains an important malignancy worldwide with poor prognosis. Long noncoding RNAs (lncRNAs) can markedly affect progression. Moreover, lncRNAs have been proposed as diagnostic or prognostic biomarkers of GC. Therefore, the current study aimed to explore lncRNA-based for LncRNA expression profiles from Gene Expression Omnibus (GEO) database were first downloaded. After re-annotation lncRNAs, a univariate Cox analysis identified 177 lncRNA probes in training set GSE62254...
Based on the relationship between gut microbiota and colorectal cancer, we developed a new probiotic powder for treatment of cancer. Initially, evaluated effect CRC using hematoxylin eosin staining, mouse survival rate tumor size. We then investigated effects microbiota, immune cells, apoptotic proteins 16S rDNA sequencing, flow cytometry, western blot, respectively. The results showed that improved intestinal barrier integrity, rate, reduced size in mice. This was associated with changes...
Objective To examine the efficacy and safety of telitacicept in treatment patients with SLE everyday clinical practice. Methods Seventy-two active who received for more than 24 weeks at multiple centres China between 2019 2022 were retrospectively identified. Twenty-one these 52 continuous telitacicept. Treatment outcomes analysed separately according to whether had renal or haematological abnormalities. Trajectory analysis was performed identify a limited response. Factors contributing...
Numerous microRNAs (miRNAs/miRs) are involved in suppressing or promoting the formation of cancer. However, to best our knowledge, role miRNA-1258 gastric cancer (GC) has not previously been investigated. Our previous study demonstrated an increased expression heparanase (HPSE) GC tissues and HPSE-facilitated invasion metastasis cells. Consequently, present study, function miR-1258 cells was investigated determine whether is associated with through HPSE. Reverse transcription-quantitative...