A5050359132- Knee injuries and reconstruction techniques
- Total Knee Arthroplasty Outcomes
- Lower Extremity Biomechanics and Pathologies
- Bone Tissue Engineering Materials
- Orthopaedic implants and arthroplasty
- Osteoarthritis Treatment and Mechanisms
- Sports injuries and prevention
- Orthopedic Infections and Treatments
- Shoulder Injury and Treatment
- Mesenchymal stem cell research
- Soft Robotics and Applications
- Tendon Structure and Treatment
- Musculoskeletal synovial abnormalities and treatments
- Orthopedic Surgery and Rehabilitation
- Periodontal Regeneration and Treatments
- Diabetic Foot Ulcer Assessment and Management
- Biomedical and Chemical Research
- Elbow and Forearm Trauma Treatment
- Glaucoma and retinal disorders
- Fibroblast Growth Factor Research
- Intracerebral and Subarachnoid Hemorrhage Research
- Antioxidants, Aging, Portulaca oleracea
- Bacteriophages and microbial interactions
- Polymer Surface Interaction Studies
- Covalent Organic Framework Applications
Dalian Medical University
2025
Inner Mongolia People's Hospital
2018-2025
First Affiliated Hospital of Dalian Medical University
2025
Peking University Third Hospital
2006-2018
Peking University
2006-2018
Osteoarthritis (OA) is a degenerative joint disease with an immense unmet medical need. FGF18 protein potential regenerative factor for cartilage repair. However, traditional delivery methods have limited efficacy due to the short lifetime and shallow infiltration. In this work, we discovered that lipid nanoparticle (LNP) can infiltrate deliver mRNA deeper in than proteins. After UTR optimization chemical modification, expression of last up 6 days cartilage. Furthermore, delivering activates...
Total meniscectomy leads to knee osteoarthritis in the long term. The poly(ε-caprolactone) (PCL) scaffold is a promising material for meniscal tissue regeneration, but cell-free scaffolds result relatively poor regeneration and lead joint degeneration.A novel, 3-dimensional (3D)-printed PCL augmented with mesenchymal stem cells (MSCs) would offer benefits cartilage protection.Controlled laboratory study.PCL were 3D printed seeded bone marrow-derived MSCs. Seventy-two New Zealand White...
A three-dimensional (3D) composite scaffold was prepared for enhanced cartilage tissue engineering, which composed of a poly(ε-caprolactone) (PCL) backbone network and poly(lactide-co-glycolide)-block-poly(ethylene glycol)-block-poly(lactide-co-glycolide) (PLGA⁻PEG⁻PLGA) thermogel surface. The not only possessed adequate mechanical strength similar to native osteochondral as benefit the PCL backbone, but also maintained cell-friendly microenvironment hydrogel. with homogeneously-controlled...
Tissue-engineered meniscus offers a possible solution to the regeneration and replacement problem of meniscectomy. However, nonuniform distribution declined proliferation seeded cells on scaffolds hinder application tissue-engineered as new generation graft. This study systematically investigated performances different seeding techniques by using demineralized cancellous bone (DCB) scaffold. Static seeding, injection centrifugal vacuum methods were used seed meniscal fibrochondrocytes (MFCs)...
Abstract Purpose To explore the impact of different repair methods for a lateral meniscus posterior root tear on biomechanics knee joint using finite element analysis. Methods Finite models healthy were established basis MRI data from volunteer Mimics software, and validity was tested. The changes in contact mechanics kinematics these under approaches then analyzed compared. Results normal had maximum area, minimum pressure, stress. When total meniscectomy performed, compartment pressure...
Objective: Lateral meniscal posterior root (LMPR) is an important stabilizer for knee joint, providing the stability during tibia forward shifting and internal rotating. It still controversial that whether LMPR tear (LMPRT) should be repaired together with ACL reconstruction. This study aims to investigate effects of on intact ACL. Methods: Eight cadaver knees were used performed biomechanical kinematics tests in orders of: Group A: was intact; B: cut off from its tibial end; C: LMPRT has...
The review focuses on the recent research trend scaffold types and biomedical applications, perspectives in meniscus tissue engineering.
As a cell source with large quantity and easy access, peripheral blood mesenchymal stem cells (PBMSCs) were isolated seeded in porcine demineralized cancellous bone (DCB) scaffolds, cultured chondrogenic medium evaluated for vitro chondrogenesis. Bone marrow MSCs (BMMSCs) articular cartilage chondrocytes (ACCs) underwent the same process as controls. The morphology, viability proliferation of PBMSCs DCB scaffolds similar to those BMMSCs ACCs. showed chondrogenesis potential consistent...
Walking is an indispensable mode of transportation for human survival. Gait a characteristic walking. In the clinic, patients with different diseases exhibit gait characteristics. analysis describes specific situation abnormalities by observing and studying kinematics dynamics limbs joints during walking depicting corresponding geometric curves values. foot ankle diseases, can evaluate degree nature in provide important basis diagnosis patients’ correction abnormal related treatment methods....
Background: Detailed knowledge of the anatomic course common peroneal nerve (CPN) is crucial for surgical treatment posterolateral corner (PLC) knee. Purpose: To investigate relationship CPN to PLC knee at different flexion angles. Study Design: Descriptive laboratory study. Methods: Ten healthy volunteers were recruited undergo magnetic resonance imaging (MRI) joint angles 0°, 30°, 60°, 90°, and 120°. MRI scans 3 levels (joint line, tibial cut, fibular tip) evaluated determine (1) distance...
Due to the irregular shape of patella and difficulty in identifying its bony landmarks, it can be a challenge for surgeons accurately symmetrically perform patellar resurfacing. Three-dimensional (3D) models 20 patellae were generated from computed tomographic images. Using computer-assisted preoperative planning technique, customized template designs developed guide The corresponding templates produced through rapid prototyping. accuracy this technique was assessed after applying on cadaver...
Meniscal allograft transplantation yields good and excellent results but is limited by donor availability. The purpose of the study was to evaluate effectiveness radiated deep-frozen xenogenic meniscal tissue (RDF-X) as an alternative graft choice in transplantation. tissues were harvested from inner 1/3 part porcine meniscus then irradiated deeply frozen. medial menisci rabbits replaced RDF-X. transplantation, meniscectomy sham operation served controls. Only a particular kind...
Ultrasound-based navigation, as a non-invasive and non-radiation image guiding system, is becoming research focus in minimally invasive navigation surgery, calibration between an ultrasonic probe 3D vision device one of the key technologies for registration-based navigation. In this paper, phantom model was designed benchmark calibration. Both iterative closet point (ICP) coherent drift (CPD) algorithms are chosen cloud registration methods to implement scanned points original set up...
INTRODUCTION The conventional total knee arthroplasty (TKA) is the most successful surgical procedure for relieving pain and improving poor function in patients with advanced arthritis. However, postoperative delayed rehabilitation are greatest complaints approach. Recently, various minimally invasive surgery (MIS) TKA-techniques have been developed to address concern. MIS-TKAs shown less pain, shorter hospital stays, quicker recovery after surgery. Inappropriate technique, inadequate...