A5101542599- Extracellular vesicles in disease
- Venous Thromboembolism Diagnosis and Management
- AI in cancer detection
- Advanced Malware Detection Techniques
- Atherosclerosis and Cardiovascular Diseases
- Machine Learning in Materials Science
- High-pressure geophysics and materials
- Cancer-related molecular mechanisms research
- Ovarian function and disorders
- Osteoarthritis Treatment and Mechanisms
- Pharmacological Effects of Natural Compounds
- Software Engineering Research
- Software Reliability and Analysis Research
- Radiomics and Machine Learning in Medical Imaging
- Electron and X-Ray Spectroscopy Techniques
- Gynecological conditions and treatments
- Systemic Lupus Erythematosus Research
- Cooperative Communication and Network Coding
- Nutrition and Health in Aging
- Diagnosis and Treatment of Venous Diseases
- Circular RNAs in diseases
- Mesenchymal stem cell research
- Rheumatoid Arthritis Research and Therapies
- Advanced X-ray Imaging Techniques
- biodegradable polymer synthesis and properties
Panyu District Central Hospital
2016-2025
Guangzhou Medical University
2024-2025
Panyu Hospital of Chinese Medicine
2019-2025
Fudan University
2025
University of Oxford
2024
Rosalind Franklin Institute
2023-2024
Rutherford Appleton Laboratory
2024
Diamond Light Source
2024
Wannan Medical College
2024
First Affiliated Hospital of Wannan Medical College
2023-2024
Diabetic foot is caused by ischemic disease of lower extremities diabetic patients, and the effective therapy very limited. Mesenchymal stem cells (MSCs) based cell had been developed into a new treatment strategy for clinically. However, underlying molecular mechanism remains to be fully addressed. Exosomes (extracellular vesicles) secreted MSCs may play crucial role in processes mediated inhibition inflammatory microenvironment as well pro-angiogenesis tissue foot.Exosomes were isolated...
Objectives The microscopic evaluation of slides has been gradually moving towards all digital in recent years, leading to the possibility for computer-aided diagnosis. It is worthwhile know similarities between deep learning models and pathologists before we put them into practical scenarios. simple criteria colorectal adenoma diagnosis make it be a perfect testbed this study. Design model was trained by 177 accurately labelled training (156 with adenoma). detailed labelling performed on...
Peritoneal fibrosis (PF) is a serious complication commonly associated with prolonged peritoneal dialysis. Mesenchymal stem cells (MSCs) and their exosomes (Exo) have shown significant therapeutic promise in treating fibrotic conditions. Danshensu (DSS), bioactive compound from the traditional Chinese herb Danshen reverses fibrosis. This study aims to investigate novel strategy enhance efficacy against PF by DSS preconditioning MSCs-derived (DSS-Exo). The vitro studies included effects of...
Abstract Osteoarthritis (OA) is a chronic musculoskeletal disease characterized by joint inflammation and progressive degeneration of articular cartilage. Currently definitive cure for OA remains to be challenge due the very low self-repair capacity cartilage, thus development more effective therapies needed cartilage repair. Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) have shown great potential as therapeutic agents stimulating regeneration However, standardized protocol...
Phase reconstruction is important in transmission electron microscopy for structural studies. We describe Fourier ptychography and its application to phase of both radiation-resistant beam-sensitive materials. demonstrate that the exit wave can be reconstructed at high resolution using a modified iterative retrieval algorithm with data collected an alternative optical geometry. This method achieves spatial 0.63 nm fluence $4.5 \times 10^2 \, e^-/\text{nm}^2$, as validated on Cry11Aa protein...
To explore the effect of multi-disciplinary cooperative mobile device-assisted drug education on satisfaction inpatients education. Mobile nursing vehicle, IPAD, and phone were used to scan QR code play propaganda videos distribute materials. Doctors, nurses pharmacists cooperated complete for inpatients. The was collected through a third-party survey. Before implementation, four satisfactions communicating about drug, understanding purpose informing role side 83.9%, 80.4%, 83.8%...
Abstract Autoimmune hepatitis (AIH) is a necroinflammatory disease associated with interactive cell populations of the innate and adaptive immune systems. The contribution conventional dendritic cells (cDCs) to AIH underlying mechanism remain poorly understood. frequency peripheral mature cDCs increased in patients was positively correlated severity. In experimental autoimmune (EAH), hepatic accumulation observed, along an increase periphery. Sequentially, bone marrow-derived (BMDC) from EAH...
Recently, an emerging trend in medical image classification is to combine radiomics framework with deep learning network integrated system. Although this combination efficient some tasks, the learning-based often difficult capture effective representation of lesion regions, and prone face challenge overfitting, leading unreliable features inaccurate results, especially when sizes lesions are small or training dataset small. In addition, these combinations mostly lack feature selection...
Atherosclerosis is the leading cause of global morbidity and mortality. Its therapy requires research in several areas, such as diagnosis early arteriosclerosis, improvement pharmacokinetics bioavailability rapamycin its therapeutic agents. Here, we used targeting peptide VHPKQHR (VHP) (or fluorescent reagent) to modify phospholipid molecules target vascular cell adhesion molecule-1 (VCAM-1) loaded ultrasmall paramagnetic iron oxide (USPIO/Fe3O4) plus (Rap) Rap/Fe3O4@VHP-Lipo...
Abstract We describe nNPipe for the automated analysis of morphologically diverse catalyst materials. Automated imaging routines and direct-electron detectors have enabled collection large data stacks over a wide range sample positions at high temporal resolution. Simultaneously, traditional image approaches are slow hence unsuitable consequently, researchers progressively turned towards machine learning deep approaches. Previous studies often detail work on uniform material systems with...
Deep vein thrombosis (DVT) is a disease caused by abnormal blood clots in deep veins. Accurate segmentation of DVT important to facilitate the diagnosis and treatment. In current study, we proposed fully automatic method delineation based on learning (DL) contrast enhanced magnetic resonance imaging (CE-MRI) images.
The objective of this study was to evaluate the effectiveness on argon-helium cryoablation combined with transcatheter arterial chemoembolization (TACE) in treating advanced hepatocellular carcinoma (HCC) and its influence factor.This trial approved by Guangzhou Panyu Central Hospital Ethics Committee. This a prospective, single-center conducted Hospital. After informed consent obtained, prospective randomized clinical data 120 patients HCC were collected. Based therapeutic scheme, divided...
Abstract Atherosclerosis is a chronic inflammatory disease characterized by the accumulation of cholesterol within arterial wall. Its progression can be monitored via magnetic resonance imaging (MRI). Ultrasmall Superparamagnetic Particles Iron Oxide (USPIO) (<5 nm) have been employed as T1 contrast agents for MRI applications. In this study, we synthesized USPIO with an average surface carboxylation approximately 5.28 nm and zeta potential −47.8 mV. These particles were phagocytosed...
Abstract Objective The primary objective of this study is to elucidate the molecular mechanism underlying reversal peritoneal fibrosis (PF) by Danshenol C, a natural compound derived from traditional Chinese medicine Salvia miltiorrhiza. By comprehensively investigating intricate interactions and signaling pathways involved in C's therapeutic effects on PF, we aim unveil novel insights into its pharmacological actions. This investigation holds potential revolutionize clinical application...
Magnetic resonance imaging (MRI) could be the ideal diagnostic modality for early rheumatoid arthritis (RA). Vascular cell adhesion molecule-1 (VCAM-1) is highly expressed in synovial locations patients with RA, which a potential target protein RA diagnosis. The peptide VHPKQHR (VHP) has high affinity to VCAM-1. To make contrast agent at an stage, we used VHP and ultrasmall paramagnetic iron oxide (USPIO) synthesize UVHP (U stands USPIO) through chemical reaction...
Abstract Ibuprofen is a nonsteroidal anti‐inflammatory agent. In this study, we compared the pharmacokinetic properties, bioequivalence, and safety of newly developed generic formulation (test) branded (reference) 0.2 g ibuprofen granules in healthy Chinese participants fasting fed arms. The randomized, single‐dose, open‐label, two‐preparation, two‐sequence, two‐period crossover study had washout period 7 days between each period. It was conducted 72 participants, 24 arm 48 arm....
Abstract This study aimed to assess the bioequivalence of 2 cefprozil dispersible tablet formulations (250 mg) in healthy Chinese volunteers under fasting and fed conditions determine pharmacokinetics cefprozil. A randomized, single‐dose, open‐label, 2‐formulation, 2‐period was conducted. The elimination period for this 7 days. Forty‐eight received 250‐mg tablets each both test reference conditions. were bioequivalent volunteers, there no significant food effect individuals receiving either...