A5011587609- Circular RNAs in diseases
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- Systemic Lupus Erythematosus Research
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Colorectal Cancer Screening and Detection
- Pharmacological Effects of Natural Compounds
- Advanced Proteomics Techniques and Applications
- RNA Research and Splicing
- Single-cell and spatial transcriptomics
- RNA modifications and cancer
- Metabolomics and Mass Spectrometry Studies
- Cancer, Lipids, and Metabolism
- Immune cells in cancer
- Genetic factors in colorectal cancer
- Gastric Cancer Management and Outcomes
- Ferroptosis and cancer prognosis
- Geography Education and Pedagogy
- Cancer, Hypoxia, and Metabolism
- Peptidase Inhibition and Analysis
- Metal-Organic Frameworks: Synthesis and Applications
- Prostate Cancer Treatment and Research
- Diet, Metabolism, and Disease
Panyu District Central Hospital
2022-2024
Guangzhou Medical University
2024
Jinan University
2024
South China Normal University
2023
Guangzhou University of Chinese Medicine
2023
Anhui University of Science and Technology
2018
Jiangxi Normal University
2010
Abstract Fenugreek is an ancient herb that has been used for centuries to treat diabetes. However, how the fenugreek‐derived chemical compounds work in treating diabetes remains unclarified. Herein, we integrate molecular docking and network pharmacology elucidate active constituents potential mechanisms of fenugreek against First, 19 from 71 key diabetes‐related targets were identified through analysis. Then, simulations results suggest diosgenin, luteolin quercetin via regulation genes...
Background Noninvasive methods for the early identify diagnosis of prostatitis, benign prostatic hyperplasia (BPH), and prostate cancer (PCa) are current clinical challenges. Methods The serum metabolites 20 healthy individuals patients with BPH, or PCa were identified using untargeted liquid chromatography-mass spectrometry (LC-MS). In addition, targeted LC-MS was used to verify organic acid in a validation cohort. Results Organic had good sensitivity specificity differentiating PCa. Three...
Purpose Sepsis-induced cardiomyopathy (SIC) is a major life-threatening condition in critically infected patients. Early diagnosis and intervention are important to improve patient prognosis. Recognizing the pivotal involvement of glycolytic pathway SIC, this study aims establish glycolysis-related ceRNA network explore novel diagnostic avenues. Materials methods SIC-related datasets were carefully filtered from GEO database. CytoHubba was used identify differentially expressed genes (DEGs)...
CRC is a malignant tumor seriously threatening human health. Quercetin and kaempferol are representative components of traditional Chinese medicine (TCM). Previous studies have shown that both quercetin antitumor pharmacological effects, nevertheless, the underlying mechanism action remains unclear. To explore synergy in colorectal cancer.
Abstract Objective The primary objective of this study is to elucidate the molecular mechanism underlying reversal peritoneal fibrosis (PF) by Danshenol C, a natural compound derived from traditional Chinese medicine Salvia miltiorrhiza. By comprehensively investigating intricate interactions and signaling pathways involved in C's therapeutic effects on PF, we aim unveil novel insights into its pharmacological actions. This investigation holds potential revolutionize clinical application...
Colorectal cancer (CRC) is among the most prevalent and life-threatening malignancies worldwide. Syndecan-2 methylation (mSDC2) testing has emerged as a widely used biomarker for early detection of CRC in stool serum samples. Cancer mSDC2
Objective. To determine the effects of circSPECC1 (hsa_circ_0000745) on proliferation and migration LNCaP prostate cancer cells to explore potential molecular mechanism. Methods. Stable shRNA-expressing circSPECC1-overexpressing cell lines were constructed, relative gene expression levels determined by RT-PCR. MTT clonogenic assays used assess proliferative ability while a scratch test was analyze migration. Western blotting protein levels. The observed in vivo. Results. found be derived...
Circulating proteins secreted by tumors are an important source of cancer biomarkers. This study aims to investigate the changes in content tumor immune-related circulating peripheral blood from patients with colorectal (CRC).
Under the guidance concept of "Changing Student's Learning Mode", Inquiry-based Geographic Course has been tried all over world. This paper took a research project "Landfill Site Selection" in geographic course "GIS Introduction" normal university as case study, made detailed description process and assessment performance among students to validate efficacy approach.
Background: The key circular RNAs (circRNAs) and the molecular mechanisms by which they regulate progression of acute myeloid leukemia (AML) in adults are unclear. Methods: We used a circRNA microarray to analyze differentially expressed circRNAs peripheral blood mononuclear cells newly diagnosed adult AML patients. Reverse transcription-PCR, fluorescence situ hybridization, Sanger sequencing, ribonuclease R tests were examine circRNF220 loop formation stability its potential value...
Abstract Purpose: To validate the effectiveness of fecal DNA Syndecan-2 methylation (m SDC2 ) test in detection colorectal cancer high-risk population China. This may provide evidence-based data diagnostic or screening for Methods A Chinese pilot comprising 1130 individuals aged 40-79 was registered (CRC) using m test. The sensitivity and specificity to CRC, advanced adenomas (AA), neoplasia (ACN) were estimated. High-risk factors incidence lesions analyzed then constructed a logistic...
Objectives To identify the most significantly differentially expressed circular RNAs (circRNAs) in colorectal cancer (CRC) tissues terms of their expression levels and circularity, to analyze relationship between clinical characteristics patients. Methods circRNA RNA-seq technology was used screen circRNAs CRC. Sanger sequencing back-splice junction sites. The relative hsa_circ_0003761 (circMSH3) CRC cell lines were detected by quantitative real-time fluorescence PCR technology. An...
Abstract Background: The key circular RNAs (circRNAs) and the molecular mechanisms by which they regulate progression of acute myeloid leukemia (AML) in adults are unclear. Methods: We used a circRNA microarray to analyze differentially expressed circRNAs peripheral blood mononuclear cells newly diagnosed adult AML patients. Reverse transcription-PCR, fluorescence situ hybridization, Sanger sequencing, ribonuclease R tests were examine circRNF220 loop formation stability its potential value...