J. He

ORCID: 0009-0009-0457-9105
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About
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Research Areas
  • biodegradable polymer synthesis and properties
  • Silicone and Siloxane Chemistry
  • Aerogels and thermal insulation
  • Advanced Polymer Synthesis and Characterization
  • Diatoms and Algae Research
  • Hydrogels: synthesis, properties, applications
  • Photopolymerization techniques and applications
  • Advanced Theoretical and Applied Studies in Material Sciences and Geometry
  • Adsorption, diffusion, and thermodynamic properties of materials
  • Innovations in Concrete and Construction Materials
  • Surface Modification and Superhydrophobicity
  • Catalysis and Oxidation Reactions
  • Advanced Thermodynamics and Statistical Mechanics
  • Recycling and utilization of industrial and municipal waste in materials production
  • Advanced Battery Materials and Technologies
  • Polysaccharides Composition and Applications
  • Advancements in Battery Materials
  • Building materials and conservation
  • Material Properties and Applications
  • Synthesis and properties of polymers
  • Injection Molding Process and Properties
  • Fiber-reinforced polymer composites
  • Calcium Carbonate Crystallization and Inhibition
  • Polymer Nanocomposites and Properties
  • RNA Interference and Gene Delivery

Foshan University
2024

Panyu District Central Hospital
2024

Guangzhou Medical University
2024

Shenzhen University
2023

Chinese Academy of Sciences
2016

<title>Abstract</title> Oligonucleotide therapeutics, including antisense oligonucleotides (ASOs) and duplex RNAs like siRNA, saRNA miRNA, hold immense potential for treating genetic acquired diseases by modulating gene expression in a target-specific manner. However, effective delivery to extrahepatic tissues, particularly the central nervous system (CNS), remains significant challenge. While GalNAc conjugation has enabled liver-specific delivery, leading several approved siRNA drugs...

10.21203/rs.3.rs-5904176/v1 preprint EN cc-by Research Square (Research Square) 2025-03-26

ABSTRACT Oligonucleotide therapeutics, including antisense oligonucleotides (ASOs) and duplex RNAs like siRNA, saRNA, miRNA, hold immense potential for treating genetic acquired diseases by modulating gene expression in a target-specific manner. However, effective delivery to extrahepatic tissues, particularly the central nervous system (CNS), remains significant challenge. While GalNAc conjugation has enabled liver-specific delivery, leading several approved siRNA drugs hepatic targets, CNS...

10.1101/2024.10.29.620792 preprint EN bioRxiv (Cold Spring Harbor Laboratory) 2024-10-29
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