A5101752317- Cancer Genomics and Diagnostics
- Colorectal Cancer Treatments and Studies
- Cancer-related molecular mechanisms research
- Multiple Myeloma Research and Treatments
- Genetic factors in colorectal cancer
- Lung Cancer Treatments and Mutations
- Cancer, Lipids, and Metabolism
- Esophageal Cancer Research and Treatment
- MicroRNA in disease regulation
- Wnt/β-catenin signaling in development and cancer
- Cancer Immunotherapy and Biomarkers
- Cytokine Signaling Pathways and Interactions
- Advanced Statistical Process Monitoring
- Ginseng Biological Effects and Applications
- Pharmacological Effects of Natural Compounds
- Clinical Laboratory Practices and Quality Control
- Chronic Lymphocytic Leukemia Research
- Ferroptosis and cancer prognosis
- Renal cell carcinoma treatment
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Advanced Proteomics Techniques and Applications
- Statistical Methods in Clinical Trials
The First Affiliated Hospital, Sun Yat-sen University
2017-2025
Zhongshan Hospital
2017-2025
Fudan University
2017-2025
Sun Yat-sen University
2017-2025
Stomatology Hospital
2025
Shenzhen University
2025
Panyu District Central Hospital
2024
Guangzhou Medical University
2024
First Hospital of Shijiazhuang
2024
Second People’s Hospital of Huai’an
2017
Non‐coding RNAs have been reported to participate in the pathophysiology of neuropathic pain. The objective our study was investigate biological role XIST pain development. In study, we identify and validate that lncRNA markedly increased miR‐137 significantly decreased chronic constriction injury (CCI) rats. silencing alleviated behaviors including both mechanical thermal hyperalgesia CCI predicted interact with by bioinformatics technology dual‐luciferase reporter assays confirmed...
An increasing number of studies have reported that lncRNAs are responsible for the development neuropathic pain. In our current study, chronic constriction injury (CCI) rat models were established and we observed lncRNA XIST was greatly increased. Knockdown can relieve pain characteristics including both mechanical thermal hyperalgesia in CCI rats. Meanwhile, down‐regulation could inhibit neuro‐inflammation by reducing expression inflammatory cytokines tumor necrosis factor (TNF)‐α, IL‐1β,...
Abstract Objectives Recent advances in information technology have renewed interest patient-based real-time quality control (PBRTQC) as an alternative to internal (IQC). However, since regulations mandate IQC, PBRTQC can only be implemented a separate system. The additional labor required for may hinder widespread adoption. Therefore, more efficient system that integrates IQC with is needed laboratories implement the methods effectively. Methods A QC proposed. maximum average number of...
To explore the possible diagnostic value of liquid biopsy, two multiplex panels using picoliter-droplet digital polymerase chain reaction (ddPCR) were established to quantitatively assess epidermal growth factor receptor (EGFR) mutations in cell‑free DNA (cfDNA) extracted from plasma advanced non‑small cell lung cancer (NSCLC) patients. Plasma samples derived 22 patients with stage IIIB/IV NSCLC harboring EGFR matched tumor tissues confirmed by amplification refractory mutation system (ARMS)...
Abstract Background Evaluating the tumor RAS/BRAF status is important for treatment selection and prognosis assessment in metastatic colorectal cancer (mCRC) patients. Correction of artifacts from library preparation sequencing essential accurately analyzing circulating DNA (ctDNA) mutations. Here, we assessed analytical clinical performance a novel amplicon-based next-generation (NGS) assay, Firefly™, which employs concatemer-based error correction strategy. Methods Firefly assay targeting...
One of the primary reasons for failure therapy in nasopharyngeal cancer (NPC) is radio resistance-related localized one, which may lead to tumor residuals or recurrences. Several studies have linked interleukin-10 (IL-10) crucial functions development and response therapy. Its function NPC's resistance is, however, not well understood. Enzyme-linked immunosorbent assay (ELISA) quantitative real-time PCR were utilized confirming IL-10 expression NPC cell lines. The prognostic significance was...
Circulating proteins secreted by tumors are an important source of cancer biomarkers. This study aims to investigate the changes in content tumor immune-related circulating peripheral blood from patients with colorectal (CRC).
e15083 Background: Clonal hematopoiesis (CH) leads to blood-derived somatic mutations in KRAS, NRAS and BRAF. Our aim is identify the prevalence of CH-derived these three genes metastatic colorectal cancer (mCRC) patients reveal practical clinical implication on plasma genotyping. Methods: We analyzed BRAF genotypes matched tumor tissues 236 mCRC through next-generation sequencing (NGS) polymerase chain reaction. Suspected CH were defined as those only detected with variant allelic...
e15084 Background: Evaluating the tumor RAS/BRAF status is important for treatment selection and prognosis assessment in metastatic colorectal cancer (mCRC) patients. Correction of artifacts from library preparation sequencing essential accurately analyzing circulating DNA (ctDNA) mutations. Here, we assessed analytical clinical performance a novel amplicon-based next-generation (NGS) assay, Firefly, which employs concatemer-based error correction strategy. Methods: Firefly assay targeting...