A5031292783- Plant-Microbe Interactions and Immunity
- Autophagy in Disease and Therapy
- Plant Stress Responses and Tolerance
- Plant nutrient uptake and metabolism
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Plant Pathogenic Bacteria Studies
- Liver Disease Diagnosis and Treatment
- Plant Parasitism and Resistance
- Biofuel production and bioconversion
- Plant Molecular Biology Research
- Plant Virus Research Studies
- Phytoplasmas and Hemiptera pathogens
- Plant responses to water stress
- Plant pathogens and resistance mechanisms
- Microscopic Colitis
- Immunotherapy and Immune Responses
- Atherosclerosis and Cardiovascular Diseases
- Dialysis and Renal Disease Management
- Vascular Procedures and Complications
- Central Venous Catheters and Hemodialysis
- Plant Gene Expression Analysis
- Plant Disease Resistance and Genetics
- Inflammatory Bowel Disease
- Heavy metals in environment
South China Normal University
2016-2025
Inner Mongolia University
2024
Anhui University of Traditional Chinese Medicine
2024
Huazhong University of Science and Technology
2018-2024
Central Hospital of Wuhan
2010-2024
Guangxi University
2024
University of North Carolina at Chapel Hill
2020-2023
Guangdong Provincial People's Hospital
2004-2020
Key Laboratory of Guangdong Province
2020
Nankai University
2017
Cadmium (Cd) is a highly toxic heavy metal that causes changes in plant metabolism through inhibiting photosynthesis and respiration. The effects of Cd on the morphology function chloroplast mitochondria, as well production localization ROS (reactive oxygen species), were studied at single-cell level Arabidopsis.The present study showed chloroplasts changed after treatment, photochemical efficiency dramatically declined prior to obvious morphological distortion chloroplasts. A quick burst...
BackgroundChlorosis of leaf tissue normally observed during pathogen infection may result from the degradation chloroplasts. There is a growing evidence to suggest that chloroplast plays significant role infection. Although most organelles and cellular structures in plants mediated by autophagy, its catabolism largely unknown. ResultsIn this study, we investigated function autophagy avirulent Pst DC3000 (AvrRps4) We examined expression defensive marker genes suppression bacterial growth...
Microbial bioremediation is a promising technology to treat heavy metal-contaminated soils. However, the efficiency of filamentous fungi as agents remains unknown, and detoxification mechanism metals by unclear. Therefore, in this study, we investigated cell morphology antioxidant systems Penicillium chrysogenum XJ-1 response different Cd concentrations (0–10 mM) using physico-chemical biochemical methods. was mainly bound wall. The malondialdehyde (MDA) level cells increased 14.82–94.67...
Gold nanoparticles (AuNPs) have been widely used as gene silencing agents and therapeutics for treatment due to their high transfection efficiency lack of cytotoxicity, but roles in plants not yet reported.
Autophagy-related gene 6 (ATG6) plays a crucial role in plant immunity. Nonexpressor of pathogenesis-related genes1 (NPR1) acts as signaling hub However, the relationship between ATG6 and NPR1 is unclear. Here, we find that directly interacts with NPR1. overexpression significantly increased nuclear accumulation Furthermore, demonstrate increases protein levels improves its stability. Interestingly, promotes formation SINCs (SA-induced condensates)-like condensates. Additionally,...
Autophagy-related gene 6 (ATG6) plays a crucial role in plant immunity. Nonexpressor of pathogenesis-related genes 1 (NPR1) acts as signaling hub However, the relationship between ATG6 and NPR1 is unclear. Here, we find that directly interacts with NPR1. overexpression significantly increased nuclear accumulation Furthermore, demonstrate increases protein levels improves its stability. Interestingly, promotes formation SINCs (SA-induced condensates)-like condensates. Additionally,...
Background Golgi protein-73 (GP73) is a newly identified candidate serum marker for liver diseases. The utility of this biomarker remains limited, largely due to the lack quantitative information. aims study were quantify GP73 (sGP73) in healthy individuals and patients with diseases, validate sGP73 as early diagnosis disease. Methods Recombinant was used generate monoclonal (mAb) polyclonal antibodies (pAb). Using these enzyme-linked immunosorbent assay, measured from 263 various forms...
Huanglongbing (HLB) is a devastating disease of citrus, which mostly caused by Candidatus Liberibacter asiaticus (CLas). To realize the specific application nano-transgenic technology in HLB, AuNPs-PEI (Gold Nanoparticles-Polyethylenimine) was used to carry foreign genes into leaves periwinkle (Catharanthus roseus) infiltration. Here, we demonstrated that NPR1-GFP protein expression observed from 12th hour 10th day after infiltrating AuNPs-PEI-pNPR1 (Arabidopsis thaliana nonexpressor...
Atherosclerosis is the leading cause of global morbidity and mortality. Its therapy requires research in several areas, such as diagnosis early arteriosclerosis, improvement pharmacokinetics bioavailability rapamycin its therapeutic agents. Here, we used targeting peptide VHPKQHR (VHP) (or fluorescent reagent) to modify phospholipid molecules target vascular cell adhesion molecule-1 (VCAM-1) loaded ultrasmall paramagnetic iron oxide (USPIO/Fe3O4) plus (Rap) Rap/Fe3O4@VHP-Lipo...
Background: Chronic kidney disease-associated pruritus (CKD-aP) is very common and sometimes refractory to treatment in hemodialysis patients. In a trial conducted Japan, nalfurafine, effectively reduced itching of treatment-resistant CKD-aP. Our present bridging study aimed evaluate the efficacy safety nalfurafine Chinese cohort with CKD-aP.Methods: this phase III, multicenter at 22 sites China, 141 cases CKD-aP were randomly (2:2:1) assigned receive 5 μg, 2.5 μg or placebo orally for 14...
The present study compared the efficacy of standard and extended durations PEG-IFNα-2a monotherapy for treatment HBeAg-negative Chinese patients with chronic hepatitis B. Patients were randomized to receive therapy (n = 38; 48 weeks treatment) or 42; 72 treatment). Extended resulted in a significantly higher HBV DNA inhibition at 24 after end treatment, sustained lower HBsAg level (P < 0.05 all comparisons). clearance rate was greater group than post-treatment (33.3% vs. 10.5% 35.7% 10.5%,...
INTRODUCTION: Children with inflammatory bowel disease (IBD) may respond differently to COVID-19 immunization as compared healthy children or adults IBD. Those younger than 12 years receive a lower vaccine dose adults. We sought describe the safety and humoral immune response in METHODS: recruited IBD, ages 5–17 years, who received ≥ 2 doses of BNT162b2 by direct-to-patient outreach at select sites. Patient demographics, IBD characteristics, medication use, adverse events were collected. A...
Damaged or unwanted cellular proteins are degraded by either autophagy the ubiquitin/proteasome pathway. In Arabidopsis thaliana, sensing of D-glucose is achieved heterotrimeric G protein complex and regulator G-protein signaling 1 (AtRGS1). Here, we showed that starvation increases proteasome-independent AtRGS1 degradation, it correlated with increased autophagic flux. RGS1 promoted production autophagosomes flux; RGS1-yellow fluorescent (YFP) was surrounded vacuolar dye FM4-64 (red...
Psm ES4326/AvrRpt2 (AvrRpt2) was widely used as the reaction system of hypersensitive response (HR) in Arabidopsis. The study showed that npr1 (GFP-ATG8a), AvrRpt2 more effective at inducing production autophagosome and autophagy flux than GFP-ATG8a. mRNA expression ATG1, ATG6 ATG8a were during early HR. Based on transcriptome data analysis, enhanced disease susceptibility 1 (EDS1) up-regulated wild-type (WT) but not induced atg4a4b (ATG4 deletion mutant) infection. Compared with WT, had...
Patients with low hepatitis B surface antigen (HBsAg) levels and virus (HBV) DNA suppression by nucleos(t)ide analogues (NAs) achieve high rate of HBsAg loss through switching to PegIFNα in pre-registration study. The aim this study was higher extended PegIFN treatment. 98 patients < 2,000 IU/ml HBV 20 were randomized receive PegIFNα-2b or continuing NA therapy for 60 weeks. At the end treatment (EOT) follow-up (EOF), only who switched achieved (32.6%) seroconversion (27.9% 25.6%). also...