A5100771412- Pancreatic and Hepatic Oncology Research
- Intracerebral and Subarachnoid Hemorrhage Research
- Intracranial Aneurysms: Treatment and Complications
- Cancer Cells and Metastasis
- Vascular Malformations Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Ubiquitin and proteasome pathways
- IL-33, ST2, and ILC Pathways
- Gallbladder and Bile Duct Disorders
- Cardiac Imaging and Diagnostics
- S100 Proteins and Annexins
- Neuroendocrine Tumor Research Advances
- Pancreatitis Pathology and Treatment
- Psoriasis: Treatment and Pathogenesis
- Esophageal and GI Pathology
- Alzheimer's disease research and treatments
- Pituitary Gland Disorders and Treatments
- Moyamoya disease diagnosis and treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Plant biochemistry and biosynthesis
- Biochemical and Structural Characterization
- Axon Guidance and Neuronal Signaling
- Phagocytosis and Immune Regulation
- Circular RNAs in diseases
- Osteoarthritis Treatment and Mechanisms
Guangdong University of Technology
2023-2025
First Affiliated Hospital of Kunming Medical University
2024-2025
Kunming Medical University
2024-2025
Yantaishan Hospital
2025
Huazhong University of Science and Technology
2009-2024
Henan University of Economic and Law
2024
University of Economics and Law
2024
Xiamen University
2017-2024
West China Hospital of Sichuan University
2019-2024
Tongji Hospital
2009-2024
The presence of bacteria in diabetic wounds not only leads to the formation biofilms but also triggers oxidative stress and inflammatory responses, which hinder wound-healing process. Therefore, it is imperative formulate a comprehensive strategy that can proficiently eliminate enhance wound microenvironment. Herein, this work develops multifunctional metal-phenolic nanozymes (TA-Fe/Cu nanocapsules), wherein one-pot coordination tannic acid (TA)and Fe
Abstract Protein delivery with cell-penetrating peptide is opening up the possibility of using targets inside cells for therapeutic or biological applications; however, peptide-mediated protein commonly suffers from ineffective endosomal escape and low tolerance in serum, thereby limiting vivo efficacy. Here, we present an intracellular system consisting four modules series: peptide, pH-dependent membrane active endosome-specific protease sites a leucine zipper. This exhibits enhanced...
Microvascular dysfunction caused by hyperglycemia leads to slow healing of diabetic wounds and significantly increases the risk bacterial infection. The misuse antibiotics can also lead resistance, making management more challenging. Thus, developing new antibacterial agents or strategies overcome antibiotic resistance is highly pursued. Herein, novel supramolecular photothermal nanoparticles (MCC/CS NPs), assembled from mono-carboxyl corrole (MCC) chitosan via hydrogen bonding π-π stacking,...
Cancer stem cells (CSCs)/tumor-initiating have been defined as a subset of tumor responsible for initiating and sustaining development. Emerging evidence strongly supports the existence CSCs in various solid tumors, but they not yet identified human gallbladder carcinomas (GBC). In this study, we primary GBC cell line GBC-SD using surface markers CD44 CD133. The percentages CD44+CD133+ were 1.76-3.05% tumors 40.29% cells. These showed properties, including self-renewal, differentiation...
Background Increasing evidence suggests that alterations in gut microbiota are associated with a variety of skin diseases. However, whether this association reflects causal relationship remains unknown. We aimed to reveal the between and diseases, including psoriasis, atopic dermatitis, acne, lichen planus. Methods obtained full genetic summary data for microbiota, planus from public databases used three methods, mainly inverse variance weighting, analyze relationships these diseases using...
Abstract Recent studies suggest that the ability to form and grow tumors specifically resides in a small cell population called cancer stem cells (CSCs). These were conducted mainly on various human cancers; however, isolation characterization of from cholangiocarcinoma have not been attempted. The molecular markers CD24, CD44, CD34, epithelial adhesion molecule (EpCAM) are widely used, individually or combination, characterize some types CSCs. In this study, we used these identify...
Alzheimer's disease (AD) and Parkinson's (PD) are the top two common neurodegenerative diseases in elderly. Recent studies found α-synuclein have a key role AD. Although many clinical pathological features between AD PD shared, genetic association them remains unclear, especially whether genetically alters risk. We did not obtain any significant result (OR = 0.918, 95% CI: 0.782–1.076, P 0.291) MR analysis In with risk, we only extracted rs356182 as IV through strict screening process. The...
Objective: Macrophages are a major component of the tumor microenvironment. M1 macrophages secrete pro-inflammatory factorsthat inhibit growth and development, whereas tumor-associated (TAMs) mainly exhibit an M2 phenotype. Ourprevious studies have shown that interleukin-33/ST2 (IL-33/ST2) axis is essential for activation This studyinvestigates role IL-33/ST2 in TAMs, its effects on growth, whether it participates mutual conversionbetween phenotypes. Methods: Bone marrow-derived were...
Spontaneous intracerebral hemorrhage (SICH) has been common in China with high morbidity and mortality rates. This study aims to develop a machine learning (ML)-based predictive model for the 90-day evaluation after SICH. We retrospectively reviewed 751 patients SICH diagnosis analyzed clinical, radiographic, laboratory data. A modified Rankin scale (mRS) of 0-2 was defined as favorable functional outcome, while an mRS 3-6 unfavorable outcome. evaluated outcome six ML-based models compared...
Background There was limited high-quality evidence that illuminated the efficiency of cerebral embolic protection (CEP) use during transcatheter aortic valve replacement (TAVR) for bicuspid (BAV) stenosis. Methods and Results In this retrospective cohort study, patients with BAV stenosis undergoing TAVR or without CEP were identified by querying National Inpatient Sample database. The primary end point any stroke hospitalization. composite safety included in-hospital death stroke. We applied...