A5090283045- Monoclonal and Polyclonal Antibodies Research
- COVID-19 Clinical Research Studies
- Protein purification and stability
- Total Knee Arthroplasty Outcomes
- Vaccine Coverage and Hesitancy
- Assisted Reproductive Technology and Twin Pregnancy
- Noise Effects and Management
- COVID-19 Impact on Reproduction
- Long-Term Effects of COVID-19
- Blood transfusion and management
- SARS-CoV-2 and COVID-19 Research
- Heart Rate Variability and Autonomic Control
- Ovarian function and disorders
- Hearing Loss and Rehabilitation
- Spine and Intervertebral Disc Pathology
- Venous Thromboembolism Diagnosis and Management
- Cancer Genomics and Diagnostics
- Tuberculosis Research and Epidemiology
- Nutrition and Health in Aging
- Pancreatic and Hepatic Oncology Research
- Quantum Chromodynamics and Particle Interactions
- Cervical and Thoracic Myelopathy
- Diabetes Treatment and Management
- Clinical practice guidelines implementation
- Particle physics theoretical and experimental studies
Harvard University
2023-2025
Peking University Third Hospital
2016-2025
Peking University
2016-2025
Second Affiliated Hospital of Nanchang University
2025
Nanchang University
2025
Shaoxing People's Hospital
2025
People 's Hospital of Jilin Province
2025
Nanjing Medical University
2019-2024
University of South China
2023-2024
Jilin Agricultural University
2024
Efforts to further elucidate structure−activity relationships (SAR) within our previously disclosed series of β-quaternary amino acid linked l-cis-4,5-methanoprolinenitrile dipeptidyl peptidase IV (DPP-IV) inhibitors led the investigation vinyl substitution at β-position α-cycloalkyl-substituted glycines. Despite poor systemic exposure, vinyl-substituted compounds showed extended duration action in acute rat ex vivo plasma DPP-IV inhibition models. Oxygenated putative metabolites were...
Background: Vaccine hesitancy has been recognized as an urgent public health issue. We aimed to explore the acceptance of a COVID-19 vaccine and related factors among pregnant women, vulnerable population for vaccine-preventable diseases.
Importance Type 2 diabetes (T2D) is associated with the progression of cognitive dysfunction. Physical activity benefits cognition, but no evidence from randomized clinical trials has shown whether tai chi chuan better long-term than fitness walking in function for patients T2D and mild impairment (MCI). Objective To compare effectiveness chuan, a mind-body exercise, improving older adults MCI, walking. Design, Setting, Participants This trial was conducted between June 1, 2020, February 28,...
Abstract Background The triglyceride-glucose (TyG) index has been recognized as being an alternative cardiometabolic biomarker for insulin resistance associated with the development and prognosis of cardiovascular disease (CVD). However, prospective relationship between baseline long-term trajectories TyG carotid atherosclerosis (CAS) progression yet to be investigated. Methods This longitudinal cohort study included 10,380 adults multiple general health checks at Peking University Third...
Objective To explore the risk factors of diabetic retinopathy (DR) and sight-threatening (STDR) among Chinese patients with diabetes. Design, setting participants A cross-sectional investigation was performed in eight screening clinics six provinces across mainland China. Information about recorded clinics. Some (sex, age, diagnosis diabetes duration, systolic blood pressure (SBP), diastolic pressure, fasting glucose (FBG) glycosylated haemoglobin (HbA1c)) were all clinics, while others...
The aim of this study was to investigate the expression levels methylenetetrahydrofolate dehydrogenase (NADP + -dependent) 2 (MTHFD2) and associated clinical implications in breast cancer. MTHFD2 measured by Western blot immunohistochemistry 698 tissue sections taken from cancer patients. relationship between expression, clinicopathological parameters, prognosis subsequently determined. In comparison with para-carcinoma specimens, an enhanced observed specimens (P < 0.05). total, 41.12 %...
The aim of this study was to investigate the effects telemonitored exercise rehabilitation on patients with coronary heart disease (CHD) in China. Ninety-six stable CHD were included and analyzed (48 group 48 control group). All received routine follow-up, participated smartphone-based cardiac rehabilitation. Patients' demographic information, medical history, diagnosis treatment CHD, laboratory results collected. difference cardiopulmonary testing (CPET), blood test, echocardiographic...
COVID-19 infections are returning to many countries because of the emergence variants or declining antibody levels provided by vaccines. An additional dose vaccination is recommended be a considerable supplementary intervention. We aim explore public acceptance third vaccine and related influencing factors in China. This nationwide cross-sectional study was conducted general population among 31 provinces November, 2021. collected information on basic characteristics, knowledge attitudes,...
Background The reluctance of individuals to obtain solid vaccine-induced immunity represents a fundamental challenge containing the spread SARS-CoV-2, including its highly mutated variants. We aimed assess vaccination acceptance and associated factors for COVID-19 vaccine booster dose among elderly people (≥60 years old) in China, providing theoretical practical reference universal policy. Methods A national anonymous survey was conducted mainland China from May 25 June 8, 2022, using...
To explore inequalities in human resources for health (HRH) relation to all cause and specific mortality globally 1990-2019.Observational study.172 countries territories.Databases of the Global Burden Disease Study 2019, United Nations Statistics, Our World Data.The main outcome was age standardized per 100 000 population HRH density 10 population, secondary mortality. The Lorenz curve concentration index (CCI) were used assess trends HRH.Globally, total increased, from 56.0 1990 142.5...
Importance Prehypertension increases the risk of developing hypertension and other cardiovascular diseases. Early effective intervention for patients with prehypertension is highly important. Objective To assess efficacy Tai Chi vs aerobic exercise in prehypertension. Design, Setting, Participants This prospective, single-blinded randomized clinical trial was conducted between July 25, 2019, January 24, 2022, at 2 tertiary public hospitals China. included 342 adults aged 18 to 65 years...
Abstract Background The associations between trajectories of different health conditions and cognitive impairment among older adults were unknown. Our cohort study aimed to investigate the impact various trajectories, including sleep disturbances, depressive symptoms, functional limitations, multimorbidity, on subsequent risk impairment. Methods We conducted a prospective by using eight waves national data from Health Retirement Study (HRS 2002–2018), involving 4319 aged 60 years or in USA....
Chemical modifications can potentially change monoclonal antibody's (mAb) local or global conformation and therefore impact their efficacy as therapeutic drugs. Modifications in the complementarity-determining regions (CDRs) are especially important because they impair binding affinity of an antibody for its target drug potency a result. In order to understand on mAb attributes induced by specific chemical within CDR, hydrogen-deuterium exchange mass spectrometry (HDX MS) was used...
Background: In March 2018, the Government of India launched a direct benefit transfer (DBT) scheme to provide nutritional support for all tuberculosis (TB) patients in line with END TB strategy. Here, money (@INR 500 [~8 USD] per month) is deposited electronically into bank accounts beneficiaries. To avail benefit, are be notified NIKSHAY (web-based notification portal India's national programme) and account details. Once these details entered NIKSHAY, checked approved by programme...
Background: This study aimed to explore the association between risk perception and coronavirus disease 2019 (COVID-19) vaccine hesitancy among reproductive women in China supplement limited studies this area. Methods: From December 14, 2020, January 31, 2021, an anonymous cross-sectional online survey was conducted on COVID-19 for children China. We assessed perception, including perceived susceptibility, severity, barriers, benefits using health belief model, then classified each variable...
Given the prevalence of omicron variant and decreased immunity provided by vaccines, it is imperative to enhance resistance COVID-19 in old population. We planned explore hesitancy rate toward booster dose vaccine association between risk perception abovementioned among people aged 60 older.This national cross-sectional study was conducted mainland China from 25 May 8 June 2022, targeting who were years or above. Four dimensions extracted Health Belief Model (HBM) assess participants'...
Background Poor sleep status as a common concern is risk factor for many health problems among older people. China with an aging society lacks relevant nationwide data on the Therefore, purpose of this study was to investigate trends and disparities in quality duration adults, exploring influencing factors poor between 2008 2018. Method We used four-waves Chinese Longitudinal Healthy Longevity Survey (CLHLS) from Sleep average hours per day investigated by using questionnaires CLHLS....
Background Myopia is a serious public health issue. High school–aged adolescents in Beijing have an alarming prevalence of myopia. Therefore, determining myopia protective factors essential. Green space has certain association with that can protect against Objective This study aims to examine the effects green around schools on individual risk high and school-level prevalence. Methods was measured using normalized difference vegetation index (NDVI). A total 13,380 samples 51 were selected...