A5070271380- Neurological Disease Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Traditional Chinese Medicine Studies
- Acupuncture Treatment Research Studies
- Stroke Rehabilitation and Recovery
- Tryptophan and brain disorders
- Neurological Disorders and Treatments
- Healthcare and Venom Research
- Traditional Chinese Medicine Analysis
- Diet and metabolism studies
- Cardiac Health and Mental Health
- Medical Research and Treatments
- Acute Ischemic Stroke Management
- Nerve injury and regeneration
- Neurogenesis and neuroplasticity mechanisms
- Neuroscience and Neuropharmacology Research
- AI and Big Data Applications
- Medicinal Plant Pharmacodynamics Research
- Plant-based Medicinal Research
- Obstructive Sleep Apnea Research
- Biofield Effects and Biophysics
- Paraquat toxicity studies and treatments
- Plant-derived Lignans Synthesis and Bioactivity
- Cerebrovascular and Carotid Artery Diseases
- Heme Oxygenase-1 and Carbon Monoxide
Affiliated Hospital of Shaanxi University of Chinese Medicine
2010-2024
Shaanxi University of Chinese Medicine
2009-2023
State Administration of Traditional Chinese Medicine of the People's Republic of China
2013
Shanxi University of Traditional Chinese Medicine
2010-2011
Shanxi Normal University
2007
Shaanxi Normal University
2007
Background. The neurotrophic pathway regulated by the brain‐derived factor (BDNF) plays a crucial role in pathogenesis of poststroke depression (PSD). How traditional Chinese medicine compound preparation Xingnao Jieyu (XNJY) decoction regulates to treat PSD is unclear. Objective. This study aimed investigate antidepressant effect XNJY on rat model and molecular mechanism intervening pathway. Methods. After middle cerebral artery occlusion was established, chronic unpredictable mild stress...
Thrombotic diseases have high disability rates, mortality and seriously endanger human health safety. Platelets play an important role in the process of thrombus formation. Salvia miltiorrhiza has been widely recognized clinical practice both domestically internationally for its ability to promote blood circulation, remove stasis, antioxidant, anti-platelet aggregation, anti-atherosclerosis effects. Due multi-component, multi-pathway, multi-target characteristics aggregation mechanism...
Dementia is a progressive neurodegenerative condition, while metabolic syndrome (MetS) characterized by combination of abnormalities such as hypertension, high blood sugar, and obesity. There exists connection overlap between the two conditions in certain aspects, both are influenced to varying degrees process aging. This study presents an overview current research landscape regarding dementia MetS through bibliometric analysis.
Post-stroke depression is an affective disorder that occurs after stroke. Its pathogenesis has not yet been fully understood, and it mainly involves neurobiology, neuroanatomy, psychology. This paper provides overview on the neurobiological mechanism of post-stroke to further understand provide references for research.
The study of post-stroke constipation in Chinese medicine has been systematically described and summarized recent years. Through the relevant literature at home abroad years, we introduced historical origin, etiology, etiological mechanism prescriptions TCM from aspects internal treatment, external treatment other means analyzed explained various characteristic treatments such as acupuncture, tui-na, tuina, acupuncture point patching, enema, summarizes methods physical stimulation...
The Xingnao Jieyu capsule has been shown to effectively relieve neurologic impairments and lessen depression. It remains poorly understood whether this can be used treat post-stroke Thus, in the present study, we established a rat model of depression using left middle cerebral artery occlusions combination chronic unpredictable stress solitary housing during development. Experimental rats received intragastric perfusion with 0.82, 0.41, 0.20 g/kg capsules separately dissolved 2 mL distilled...
Cerebral small vascular disease is a common clinical neurological degenerative disease, an important risk factors of stroke, cognitive impairment and death. CSVD can be acute onset, manifested as cerebral hemorrhage or ischemic but most its onset hidden, slow progress, some patients with dysfunction dementia, memory loss, decline, etc, serious harm to the health elderly quality life. There lack early diagnosis methods intervention measures for this so clarify current situation future...
The theory of liver heat and blood stasis is one the characteristic theories in traditional Chinese medicine (TCM) for understanding, preventing, treating stroke. This article starts from physiological pathological relationships between kidney connection liver, kidney, brain TCM, elaborates on how syndrome affects precursor stroke, presents relevant modern clinical application studies.
The present study established a rat model of post-stroke depression using incomplete ischemia induced by unilateral carotid artery ligation in combination with solitary raising and subcutaneous injection small dose reserpine. After intragastric perfusion 45 mg/100 g, 15 7.5 g Xingnao Jieyu for 7, 14 21 days, neuronal morphology the frontal lobe hippocampus was improved, state voluntary behaviors were also effectively improved rats depression. Moreover, effects at similar to traditional...
To observe the effect of tonifying liver and kidney-essence herbs on expression a nerve regeneration inhibitor, Nogo for neuron A (Nogo-A), its associated signaling molecule, low-affinity neurotrophin receptor p75 (p75NTR), in rats with cerebral ischemic stroke (CIS), aim exploring possible mechanism recovery following injury to central nervous system. model SD was established suture-occlusion method. Successful were divided into placebo herb groups at random; sham-operated control set up...
The neuroinflammatory pathway regulated by nuclear factor kappa-B (NF-κB) plays an important role in the occurrence, development, and prognosis of poststroke depression (PSD). regulatory effect traditional Chinese medicine compound Xingnao Jieyu decoction (XNJY) on NF-κB PSD is still unclear. This study aimed to observe XNJY explore molecular mechanism its intervention pathway. Middle cerebral artery occlusion (MCAO) chronic unpredictable mild stress were used establish a rat model. Body...
Objective: Based on deep learning, to explore the clinical effect of early rehabilitation intervention management model recovery neurological function in patients with acute stroke. Methods: A total 86 inpatients our department from June 2019 August 2020 were selected. According ward distribution, hospital was randomly divided into routine drug treatment group (control group, 44 cases) and another comprehensive (treatment 42 cases). The received regular training addition medication, while...
Cerebral small vessel disease is a kind of aging cerebral microvascular disease, accounting for 83.8% all cerebrovascular diseases, and gradually become an important affecting human health. When vascular in the early stage, damage to cognitive function not obvious, onset often hidden.With further development behavioral dysfunction appears, which can eventually cause dementia seriously decline quality life patients. Early diagnosis intervention are great value controlling impairment caused by...