A5101705570- Dermatologic Treatments and Research
- Laser Applications in Dentistry and Medicine
- Bone Tumor Diagnosis and Treatments
- Gallbladder and Bile Duct Disorders
- Sarcoma Diagnosis and Treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Obstructive Sleep Apnea Research
- Pancreatic and Hepatic Oncology Research
- Pediatric Hepatobiliary Diseases and Treatments
- Sirtuins and Resveratrol in Medicine
- Medicinal Plants and Neuroprotection
- Neuroscience of respiration and sleep
- Advanced Breast Cancer Therapies
- Ocular and Laser Science Research
- Occupational and environmental lung diseases
- Optical Coherence Tomography Applications
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cholinesterase and Neurodegenerative Diseases
- Glutathione Transferases and Polymorphisms
- Photoacoustic and Ultrasonic Imaging
- Radiomics and Machine Learning in Medical Imaging
- PARP inhibition in cancer therapy
- Hip disorders and treatments
- Pelvic and Acetabular Injuries
- Ovarian cancer diagnosis and treatment
Hebei Medical University
2009-2025
Third Hospital of Hebei Medical University
2009-2025
Jiangsu University
2024
First People's Hospital of Kunshan
2024
Guangzhou Medical University
2024
Guangzhou Medical University Cancer Hospital
2024
Zhengzhou University
2022-2023
Hospital of Hebei Province
2023
Henan Provincial People's Hospital
2019-2023
Nanjing Medical University
2011-2022
The medicinal plant Withania somnifera has been used for over centuries in Indian Ayurvedic Medicine to treat a wide spectrum of disorders. Withaferin A (WA), bioactive compound that is isolated from this plant, anti-inflammatory, immuno-modulatory, anti-angiogenic, and anti-cancer properties. Here we investigated malignant pleural mesothelioma (MPM) suppressive effects WA the molecular mechanisms involved. inhibited growth murine as well patient-derived MPM cells part by decreasing...
The characteristics of total sagittal and coronal plane parameters in children with short stature (SS) the correlations between these are currently unknown. This case-control study sought to retrospectively investigate SS examine parameters. data aged 3-15 years normal heights were collected, allocated observation control groups, respectively. following analyzed: Cobb angle, cervical lordosis (CL) T1 slope (T1S), thoracic kyphosis (TK) lumbar (LL) sacral inclination pelvic incidence axis,...
Introduction: The purpose of this study was to investigate the morphology and distribution characteristics fat globules in osteomyelitis on magnetic resonance imaging (MRI). Materials Methods: Patients with pathologically-confirmed MRI scans were retrospectively enrolled, images analyzed. Results: Among 103 patients non-traumatic osteomyelitis, 75 globule negative 28 positive. There no statistically significant difference age gender between without (p>0.05). inflammatory indicators (CRP,...
Abstract Oxidative stress is a key regulator of idiopathic pulmonary fibrosis. Paraquat (PQ)‐induced fibrosis seriously endangers people's health. Rapamycin has been reported to alleviate PQ‐induced fibrosis, but its underlying mechanism unclear. The nuclear factor E2‐related 2 (Nrf2) plays an important regulatory role in the antioxidant therapy In this study, we tried confirm that rapamycin attenuates by regulating Nrf2 pathway. vivo, proved could inhibit degree oxidant as well enhanced...
Abstract Pulmonary fibrosis is a chronic and progressive lung disease with high mortality. This study aims to explore the protective mechanism of quercetin against pulmonary regarding cell senescence gut microbiota. Rats were intratracheally injected bleomycin (BLM) establish rat model. RLE-6TN cells stimulated BLM build model alveolar epithelial senescence, RLE-6TN-derived conditional medium (CM) was harvested further culture fibroblasts. Histopathological changes assessed by H&E Masson...
To evaluate the clinical value of dual-source CT (DSCT) coronary angiography in diagnosis artery fistula (CAF) adults.A large cohort 17,548 patients, who underwent DSCT our hospital between January 2008 and October 2013, were retrospectively reviewed for CAF. The origin, course drainage site CAF coexisting abnormalities analysed. conventional results, treatments follow-up images also evaluated.A total 33 CAFs from patients detected. incidence was 0.19% by DSCT. originating left (LCA) found...
Abstract Background Due to the inadequacy of published evidence, association telomere length (TL), obesity and tobacco smoking with idiopathic pulmonary fibrosis (IPF) remains unclear. The aim study was explore whether these exposures genetically affected risk disease. Methods Genetic variants from genome-wide studies for TL, body mass index (BMI), fat percentage (BFP) (including maternal smoking) were used as instrumental variables. Inverse-variance weighted mainly adopted determine genetic...
Selective photothermolysis is the basic principle for laser treatment of vascular malformations such as port wine stain birthmarks (PWS). During cutaneous surgery, blood inside vessels heated due to selective absorption energy, while surrounding normal tissue spared. As a result, and experience local thermodynamic non-equilibrium condition. Traditionally, PWS process was simulated by discrete-blood-vessel model that simplifies into parallel cylinders buried in multi-layer skin model. In this...
Background and Objective Port wine stains (PWS) are congenital vascular malformations that progressively darken thicken with age. Laser therapy is currently the most effective way in clinical practice for PWS. A 1,064 nm Nd:YAG laser near‐infrared band can achieve a deeper treatment depth compared to current widely adopted pulsed dye laser. However, because of its relatively weak absorption by blood, single‐pulse requires high energy density cause vessel damage, but may inflict undesirable...
Background and Objective Pulsed dye laser (PDL) is a commonly used treatment for Port Wine Stain birthmarks (PWS). However, deeper components of PWS are often resistant to PDL. Deeper penetrating lasers, including the long pulsed Neodymium:Yttrium Aluminum Garnet (Nd:YAG) have been used, but carry greater risk. This study evaluates distinct blood vessel thermal responses visible (595 nm) near infrared (1,064 lasers using animal numerical models. Study Design/Materials Methods Blood vessels...
Abstract This study was performed to propose a method, the Feature Ambiguity Mitigate Operator (FAMO) model, mitigate feature ambiguity in bone fracture detection on radiographs of various body parts. A total 9040 radiographic studies were extracted. These images classified into several part types including 1651 hand, 1302 wrist, 406 elbow, 696 shoulder, 1580 pelvic, 948 knee, 1180 ankle, and 1277 foot images. Instance segmentation annotated by radiologists. The ResNext-101+FPN employed as...
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive interstitial lung disease that leads rapidly to death. The present study aimed at discovering the in-depth pathogenesis of IPF, exploring role adiponectin/carnitine palmityl transferase 1A- (APN/CPT1A-) mediated fatty acid metabolism during development and excavating its potential mechanism. Here, THP-1 cells were differentiated into M0 macrophages, followed by polarization M1 macrophages upon hypoxia. Subsequently, fibroblast...
Idiopathic pulmonary fibrosis (IPF) is a highly fatal lung disease of unknown etiology with median survival after diagnosis only 2-3 years. Its poor prognosis due to the limited therapy options available as well lack effective prognostic indicators. This study aimed construct novel signature for IPF assist in personalized management patients during treatment.Differentially-expressed genes (DEGs) versus healthy individuals were analyzed using "limma" package R software. Immune-related (IRGs)...
Objective: To determine the neuroprotective effects and underpinning mechanisms of thrombopoietin (TPO), Matrix Metalloproteinase-9(MMP-9) Nuclear Factor-κB (NF-κB) after focal cerebral ischemia-reperfusion in rats.Methods: Male rats underwent 2 hours right middle artery occlusion (MCAO) followed by 22 reperfusion.PBS or TPO (0.1ug/kg) was administered from caudal vein before reperfusion.Neurologic deficits, brain edema, Evans blue (EB) extravasation, NF-κB MMP-9 expression were subsequently...
Cerebral ischemia-reperfusion injury can activate signal transducers and activators of transcription (STAT). STAT1 initiates neuronal apoptosis following cerebral ischemia-reperfusion, while STAT3 is neuroprotective. Erythropoietin (EPO) promotes regeneration through facilitates survival ischemia. However, there are few reports on the effects EPO phosphorylated (P-STAT1) level in rats, no evidence simultaneous observation four kinds protein:STAT1, P-STAT1, STAT3, P-STAT3.We established a rat...