A5031818289- Intracerebral and Subarachnoid Hemorrhage Research
- Mitochondrial Function and Pathology
- Acute Ischemic Stroke Management
- Heat shock proteins research
- Neurological Disease Mechanisms and Treatments
- Endoplasmic Reticulum Stress and Disease
- Cellular transport and secretion
- Neuroinflammation and Neurodegeneration Mechanisms
- Autophagy in Disease and Therapy
- MicroRNA in disease regulation
- Extracellular vesicles in disease
- Mesenchymal stem cell research
- Retinal Development and Disorders
- Biochemical effects in animals
- Parkinson's Disease Mechanisms and Treatments
- Circular RNAs in diseases
- Liver Disease Diagnosis and Treatment
- Barrier Structure and Function Studies
- Intracranial Aneurysms: Treatment and Complications
- RNA regulation and disease
- Neurosurgical Procedures and Complications
- Connexins and lens biology
- Neurogenesis and neuroplasticity mechanisms
- Cancer, Hypoxia, and Metabolism
- ATP Synthase and ATPases Research
Second Xiangya Hospital of Central South University
2016-2025
Central South University
2015-2024
University of Pittsburgh
2023-2024
Zhejiang Chinese Medical University
1969-2024
Techmart Industrial Limited (China)
2022
Gannan Medical University
2004-2022
Jiangsu Industry Technology Research Institute
2022
Tsinghua University
2022
Peking University
2010-2021
Peking University People's Hospital
2010-2021
<h3>Importance</h3> Dyslipidemia, the prevalence of which historically has been low in China, is emerging as second leading yet often unaddressed factor associated with risk cardiovascular diseases. However, recent national data on prevalence, treatment, and control dyslipidemia are lacking. <h3>Objective</h3> To assess community residents availability lipid-lowering medications primary care institutions China. <h3>Design, Setting, Participants</h3> This cross-sectional study used from...
Cerebral ischemia-reperfusion (I/R) injury often leads to neuronal death through persistent neuroinflammatory responses. Recent research has unveiled a unique inflammatory programmed cell mode known as PANoptosis. However, direct evidence for PANoptosis in ischemic stroke-induced not been established. Although it is widely thought that modulating the balance of microglial phenotypic polarization cerebral I/R could mitigate neuroinflammation-mediated death, remains unknown whether influences...
Mesenchymal stem cells (MSCs) play important roles in tissue repair and regeneration, such as the induction of angiogenesis, particularly under hypoxic conditions. However, molecular mechanisms underlying MSC activation remain largely unknown. MSC-derived extracellular vesicles (EVs) are vital mediators cell-to-cell communication can be directly utilized therapeutic agents for regeneration. Here, we explored effects EVs from human olfactory mucosa MSCs (OM-MSCs) on angiogenesis its...
The aim of this study was to determine the effects curcumin on meat quality and antioxidant profile breast muscle in broilers. In experiment 1, birds were fed basal diet with an additional 0, 50, 100, or 200 mg/kg curcumin, respectively. results showed that dietary significantly increased redness values meat, catalase activity, ABTS radical scavenging activity decreased drip loss at 48 h. 2, reared under heat stress assigned similar treatments as 1. Significant differences redox status...
Neuronal death due to over-oxidative stress responses defines the pathology of cerebral ischemic/reperfusion (I/R) insult. Ferroptosis is a form oxidative cell that induced by disruption balance between antioxidants and pro-oxidants in cells. However, potential mechanisms responsible for I/R-induced ferroptotic neuronal have not been conclusively determined. UBIAD1, newly identified antioxidant enzyme catalyzes coenzyme Q10 (CoQ10) vitamin K2 biosynthesis Golgi apparatus membrane...
Short-chain fatty acids (SCFAs) are thought to play a key role in the microbe-gut-brain axis and involve pathogenesis of variety neurological diseases. This study aimed identify research hotspots evolution trends SCFAs central nervous diseases (CNS) examine current trends.
To investigate the value of chaperonin containing TCP1, subunit 3 (CCT3) to predict prognosis patients with hepatocellular carcinoma (HCC) and determine its function in HCC progression.CCT3 expression levels were examined human non-cancerous liver tissues a variety cell lines by quantitative real-time PCR immunoblotting. CCT3 was suppressed small interfering RNA. The effects reducing cells tested. 3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyl tetrazolium bromide (MTT) assay, counting experiment,...
Recent studies have found that administration of stem cells or extracellular vehicles (EVs) derived from exert neuroprotective effects after transient global ischemia. However, the underlying mechanisms this effect remain unclear, especially at level synaptic functions. In study, we compared suppressive on cyclooxygenase-2 (COX-2) upregulation by EVs bone marrow mesenchymal (BMSC-EV), adipose tissue MSC (AdMSC-EV) and serum (serum-EV). Then examined whether BMSC-EVs could restore functional...
Background Characterizing and assessing the prevalence, awareness, treatment patterns of patients with isolated diastolic hypertension ( IDH ) can generate new knowledge highlight opportunities to improve their care. Methods Results We used data from China PEACE (Patient‐centered Evaluative Assessment Cardiac Events) Million Persons Project, which screened 2 351 035 participants aged 35 75 years between 2014 2018. was defined as systolic blood pressure <140 ≥90 mm Hg; awareness...
Now, numerous exciting findings have been yielded in the field of energy metabolism within glioma cells. In addition to aerobic glycolysis, multiple catabolic pathways are employed for production. However, prognostic significance remains obscure. Here, we explored relationship between gene profile and outcome diffuse patients using The Cancer Genome Altas (TCGA) Chinese Glioma (CGGA) datasets. Based on expression profile, consensus clustering identified two robust clusters with distinguished...
Ischemic stroke results in severe brain damage and remains one of the leading causes death disability worldwide. Effective neuroprotective therapies are needed to reduce resulting from ischemic stroke. Mitochondria crucial for cellular energy production homeostasis. Modulation mitochondrial function mediates neuroprotection against damage. Dynamin‐related protein 1 (Drp1) parkin play a key role regulating dynamics. They potential therapeutic targets Protective effects parkin‐Drp1 pathway on...