A5112089719- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Multiple Myeloma Research and Treatments
- Cancer Immunotherapy and Biomarkers
- Protein Degradation and Inhibitors
- Immune Cell Function and Interaction
- Retinal and Optic Conditions
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- melanin and skin pigmentation
- Ocular Diseases and Behçet’s Syndrome
- Cancer Diagnosis and Treatment
- Skin Protection and Aging
- Nanoplatforms for cancer theranostics
- CAR-T cell therapy research
- Advancements in Transdermal Drug Delivery
- Neurological Disease Mechanisms and Treatments
- Biochemical and Molecular Research
- Advanced Nanomaterials in Catalysis
- Extracellular vesicles in disease
- Inflammatory Myopathies and Dermatomyositis
- Hormonal and reproductive studies
- Cutaneous lymphoproliferative disorders research
- Sodium Intake and Health
- Medical Imaging Techniques and Applications
- IgG4-Related and Inflammatory Diseases
The First Affiliated Hospital, Sun Yat-sen University
2019-2025
Sun Yat-sen University
2019-2025
Institute of Hematology & Blood Diseases Hospital
2023-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2025
Peking Union Medical College Hospital
2023-2025
Yangzhou University
2019-2024
Qingdao University
2019-2024
Academy of Medical Sciences
2024
Affiliated Hospital of Qingdao University
2019-2024
Second Affiliated Hospital of Xi'an Jiaotong University
2019-2024
Background Characterizing and assessing the prevalence, awareness, treatment patterns of patients with isolated diastolic hypertension ( IDH ) can generate new knowledge highlight opportunities to improve their care. Methods Results We used data from China PEACE (Patient‐centered Evaluative Assessment Cardiac Events) Million Persons Project, which screened 2 351 035 participants aged 35 75 years between 2014 2018. was defined as systolic blood pressure <140 ≥90 mm Hg; awareness...
Photoaging, primarily caused by ultraviolet (UV) light, is the major factor in extrinsic skin aging. Existing anti-photoaging strategies mainly focus on early sun protection or repairing damaged skin, lacking a comprehensive treatment strategy. Therefore, this study developed dressing that actively shields against UV radiation and repairs photoaged offering double protection. This utilized exosome-like nanovesicles derived from
Background and Purpose: Deep tiny flow voids (DTFVs) are a specific type of collaterals surrounding chronic steno-occlusive middle cerebral artery (MCA), which can be identified on high-resolution magnetic resonance imaging (HR-MRI). This study aimed to investigate the presence DTFVs in patients with acute MCA occlusion their relevance clinical outcomes. Methods: Using data from two multicenter cohort studies, we examined analyzed characteristics. Univariable multivariable logistic linear...
To evaluate the association of GGN repeat polymorphism androgen receptor (AR) with ovarian reserve and response in controlled stimulation (COS). This genetic study was conducted among a total 361 women aged ≤40 years basal FSH≤12 U/L undergoing GnRH-agonist long protocol for COS university-affiliated IVF center. AR gene analyzed Sanger sequencing. The primary endpoint number antral follicle counts (AFCs), secondary endpoints were days, dose gonadotropin (Gn) used, retrieved oocytes,...
Abstract NK-large granular lymphocytic leukemia (NK-LGLL) is a rare chronic lymphoproliferative disorder and displays heterogeneity that remains insufficiently defined. CD56 plays pivotal role in NK-cell maturation linked to cytotoxicity. However, whether might be associated with distinctive characteristics NK-LGLL has not been determined. Hence, this study aims explore potential associations between clinical biological features 47 patients NK-LGLL. Above all, anemia (57.4%) was the most...
Abstract Context Immune checkpoint inhibitor (ICI)-related hypothyroidism is mostly irreversible and prompt thyroid hormone replacement therapy crucial, especially for patients undergoing neoadjuvant immunotherapy. Objective This study aimed to propose a novel titration strategy ICI-related hypothyroidism, evaluate levothyroxine (LT4) dose differences between patterns, develop predictive equation the optimal LT4 dose. Design Retrospective study. Setting Tertiary academic hospital. Patients...
Lung cancer, a malignant neoplasm that is globally prevalent and characterized by high incidence mortality rates, has seen the rise of immune checkpoint inhibitors (ICIs) as crucial systemic treatment. However, subset patients exhibits suboptimal responses to ICIs. Recently, studies revealed role vitamin D in inflammation modulation, cell differentiation, cancer prevention. Vitamin precisely modulates inflammatory states within tumor microenvironment (TME) targeting both innate adaptive...
Immune-related adverse events (irAEs) of immunotherapy would lead to the temporary or permanent discontinuation immune checkpoint inhibitors (ICIs). Among them, inhibitor pneumonitis (CIP) is a potentially life-threatening irAE. This study aimed identify differences between patients with low-grade CIPs (grades 1–2) and high-grade 3–5) explore prognostic factors. We retrospectively reviewed medical records 916 lung cancer who were treated ICIs. Patients identified after multidisciplinary...
The closure of large or perforated defects has posed a significant challenge in the evolution endoscopic treatments. over-the-scope (OTS) clip, once mainstay for such closures, certain limitations, as necessity pre-procedure attachment to endoscope's tip, which may entail additional surgical entries and potentially longer operative times, increasing risk complications like postoperative peritonitis [1].
Background and objectives: Atypical thymic carcinoids (ATCs) are rare mediastinal malignancies that lack established treatment guidelines. Capecitabine temozolomide (CapTem) has demonstrated significant efficacy in pancreatic neuroendocrine neoplasms (NENs), while its applicability effectiveness ATCs remain underexplored. This study seeks to investigate the efficacy, safety, prognostic factors associated with CapTem ATC patients. Design methods: Thirty-eight patients treated at our center...
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e14683 Background: Checkpoint inhibitor pneumonitis (CIP) is a relatively uncommon but potentially life-threatening immune-related adverse event (irAE). Lung biopsies have not been commonly performed for CIP patients. Bronchoalveolar lavage fluid (BALF) analysis useful diagnostic approach interstitial lung disease. However, BALF features were inconsistent across different studies. Methods: We retrospectively reviewed the medical records of 154 patients with pathologically confirmed...
<h3>Background:</h3> Behçet's syndrome (BS) is a chronic, recurrent systemic vasculitis that can affect multiple systems. Neuro-Behçet's (NBS), especially parenchymal NBS(p-NBS), results in severe neurological sequelae with poor prognosis, ranging from cognitive changes to paralysis, which remains challenging clinical issue. <h3>Objectives:</h3> This study aimed evaluate the efficacy and safety of infliximab (IFX), type anti-TNF-α agents, treating patients p-NBS hopefully provide detailed...
Abstract Purpose Cutaneous metastasis (CM) accounts for 5–30% of patients with breast cancer (BC) and presents unfavorable response to treatment poor prognosis. A better understanding the molecular alterations involved in is essential, which would help identify diagnostic efficacy biomarkers CM. Materials : We retrospectively reviewed a total 13 histological or cytological diagnosis Clinical information was extracted from medical records. The mutational landscape matched primary tumors their...