A5101873405- Paraquat toxicity studies and treatments
- Heme Oxygenase-1 and Carbon Monoxide
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Hemoglobinopathies and Related Disorders
- Plant Micronutrient Interactions and Effects
- Pesticide Exposure and Toxicity
- Plant responses to water stress
- Hydrogen's biological and therapeutic effects
- MicroRNA in disease regulation
- Sulfur Compounds in Biology
Ningbo No. 2 Hospital
2025
Kunming Medical University
2017-2020
Pulmonary fibrosis (PF) is an irreversible, progressive, chronic and fatal interstitial lung disease with limited therapeutic options. Dehydrocorydaline (DHC), derived from the traditional Chinese medicinal plant Corydalis yanhusuo, has exhibited a variety of pharmacological properties. Nevertheless, potential function mechanism DHC in management PF have yet to be elucidated. To evaluate therapeutical efficacy different models elucidate its underlying mechanism. A well-established...
Abstract Oxidative stress is a key regulator of idiopathic pulmonary fibrosis. Paraquat (PQ)‐induced fibrosis seriously endangers people's health. Rapamycin has been reported to alleviate PQ‐induced fibrosis, but its underlying mechanism unclear. The nuclear factor E2‐related 2 (Nrf2) plays an important regulatory role in the antioxidant therapy In this study, we tried confirm that rapamycin attenuates by regulating Nrf2 pathway. vivo, proved could inhibit degree oxidant as well enhanced...
To investigate the effects of hydrogen water on proliferation, differentiation, collagen secretion and Nrf2 expression in paraquat-induced human lung fibroblasts.In vitro cultured fibroblasts (HFL1) exposed to 600 μmol/L paraquat (PQ) for 24 h were treated with or without RNA interference expression. The changes cell proliferation examined using MTT assay, expressions Col-I, Col-III, α-SMA cells detected Western blotting, real-time quantitative PCR immunofluorescence assay. contents SOD, CAT...
Paraquat (PQ) is a herbicide that widely used in developing countries, and pulmonary fibrosisis one of the most typical features PQ poisoning. The molecular mechanism underlying toxicity largely unknown, which makes it difficult to treat. In present study, western blot analysis, reverse transcription‑quantitative polymerase chain reaction fluorescent immunostaining were analyze effects rapamycin on PQ‑induced epithelial‑mesenchymal transition (EMT) A549 MRC‑5 cells. It was revealed...