A5056141249- Chronic Obstructive Pulmonary Disease (COPD) Research
- Obstructive Sleep Apnea Research
- Neuroscience of respiration and sleep
- Cancer, Hypoxia, and Metabolism
- Asthma and respiratory diseases
- High Altitude and Hypoxia
- Respiratory Support and Mechanisms
- Adipose Tissue and Metabolism
- Sleep and Wakefulness Research
- Respiratory and Cough-Related Research
- COVID-19 Clinical Research Studies
- Pediatric health and respiratory diseases
- Inflammasome and immune disorders
- SARS-CoV-2 and COVID-19 Research
- Mitochondrial Function and Pathology
- Liver Disease Diagnosis and Treatment
- Eicosanoids and Hypertension Pharmacology
- Cancer-related molecular mechanisms research
- Emergency and Acute Care Studies
- RNA modifications and cancer
- Heme Oxygenase-1 and Carbon Monoxide
- Long-Term Effects of COVID-19
- Endoplasmic Reticulum Stress and Disease
- Neuroinflammation and Neurodegeneration Mechanisms
- Nitric Oxide and Endothelin Effects
Huazhong University of Science and Technology
2015-2025
Tongji Hospital
2016-2025
Army Medical University
2022
Southwest Hospital
2022
The 180th Hospital of PLA
2022
National Natural Science Foundation of China
2013-2017
University of Shanghai for Science and Technology
2017
Guizhou Institute of Technology
2015-2017
Public Health Institute
2015
Indiana University Bloomington
2013
Abstract Background The 2019 novel coronavirus (2019-nCoV) causing an outbreak of pneumonia in Wuhan, Hubei province China was isolated January 2020. This study aims to investigate its epidemiologic history, and analyze the clinical characteristics, treatment regimens, prognosis patients infected with 2019-nCoV during this outbreak. Methods Clinical data from 137 2019-nCoV-infected admitted respiratory departments nine tertiary hospitals December 30, 24, 2020 were retrospectively collected,...
Abstract Background Since early December 2019, the 2019 novel coronavirus disease (COVID-19) has caused pneumonia epidemic in Wuhan, Hubei province of China. This study aimed to investigate factors affecting progression COVID-19 patients. Associated results will be used evaluate prognosis and find optimal treatment regimens for pneumonia. Methods Patients tested positive based on nucleic acid detection were included this study. admitted 3 tertiary hospitals Wuhan between 30, January 15,...
Abstract Background The 2019 novel coronavirus has caused the outbreak of acute respiratory disease in Wuhan, Hubei Province China since December 2019. This study was performed to analyze clinical characteristics patients who succumbed and recovered from (COVID-19). Methods Clinical data were collected two tertiary hospitals Wuhan. A retrospective investigation conducted fatal cases COVID-19 (death group) we compare them with (recovered group). Continuous variables analyzed using...
BACKGROUND. Fatal cases of COVID-19 are increasing globally. We retrospectively investigated the potential immunologic parameters as early predictors COVID-19.
With a large number of COVID-19 patients discharging from hospital, some had showed re-fever and positive nucleic acid test after discharge hospital. This might be due to the biological characteristics 2019-nCoV, also related basic disease, clinical status, glucocorticoid using, sample sampling, processing detecting patients, even re-infection or secondary bacterial virus infection. Therefore, we suggest that in view this phenomenon, further stratified management hospital should carried out...
Abstract A drug conjugate consists of a cytotoxic bound via linker to targeted ligand, allowing the delivery one or more tumor sites. This approach simultaneously reduces toxicity and increases efficacy, with powerful combination efficient killing precise targeting. Antibody‒drug conjugates (ADCs) are best-known type conjugate, combining specificity antibodies cytotoxicity chemotherapeutic drugs reduce adverse reactions by preferentially targeting payload tumor. The structure ADCs has also...
Abstract Background Neutrophilic airway inflammation is a challenge in asthma management and associated with poor patient prognosis. Mucin 1 (MUC1), which contains cytoplasmic tail (MUC1-CT), has been found to mediate glucocorticoid sensitivity asthma; however, its role modulating neutrophilic remains unknown. Methods Human-induced sputum cells were collected from healthy participants (n = 12), patients mild-to-moderate 34), those severe 18). In vitro human lung bronchial epithelial cell...
Abstract Background Data related to the characteristics, treatments and clinical outcomes of acute exacerbation chronic obstructive pulmonary disease (AECOPD) patients in China are limited, sex differences still a neglected topic. Methods The hospitalized for AECOPD were prospectively enrolled from ten medical centers between September 2017 July 2021. Patients some received follow-up 3 years. regarding in-hospital long-term male female included cohort analyzed compared. Results In total,...
Abstract Emerging studies have shown that the aberrant expression and function of long non-coding RNAs (lncRNAs) are involved in carcinogenesis development various cancers. The noncoding RNA JPX (lncRNA JPX) on X chromosome is an activator X-inactive-specific transcript (XIST) a molecular switch for X-chromosome inactivation. However, exact mechanism by which acts non-small-cell lung cancer (NSCLC) not well studied. Here, through integrating clinical data series functional experiments, we...
Abstract Cancer immunotherapy has great potential in tumor eradication and metastasis suppression. However, systemic administration of immune adjuvants inadequate specificity cancer treatment, lead to restricted therapeutic benefits immune‐related side effects clinical settings. In this report, the synthesis various lengths heptamethine cyanine small molecules act as multifunctional photosensitizers (PS) for tumor‐specific accumulation, near‐infrared (NIR) fluorescent imaging,...
According to the latest epidemiological investigation, lung adenocarcinoma (LUAD) is one of most fatal cancer among both men and women. Despite continuous advancements in treatment approaches recent years, prognosis for LUAD remains relatively poor. Given crucial role solute carrier (SLC) family maintaining cellular energy metabolism stability, we conducted a comprehensive analysis association between SLC genes prognosis. In present study, identified 71 members, which 32 were downregulated...
Gefitinib exhibits significant clinical efficacy in patients with non-small cell lung cancer (NSCLC) harboring epidermal growth factor receptor (EGFR) sensitive mutations. However, its is severely limited by acquired resistance. Herein, we designed and synthesized a series of dual-targeting thioredoxin reductase (TrxR)-EGFR gold complexes attaching ligand to the parent structure gefitinib, 4-anilinoquinazoline. Among them, L1Au2 exhibited activity against both gefitinib-sensitive resistant...
Sex differences in the risk of venous thromboembolism (VTE) among patients with an acute exacerbation chronic obstructive pulmonary disease (AECOPD) have so far only been sparsely described. This study aimed to investigate VTE events between male and female AECOPD determine whether any specific factors for vary sexes. We prospectively enrolled hospitalized from ten medical centers China. The primary outcome was occurrence VTE. Univariate multivariate logistic regression analyses were...
Objective: We examined whether race/ethnicity was related to exposure acute economic losses in the 2008–2009 recession, even accounting for individual-level and geographic variables, it influenced associations between drinking patterns problems. Method: Data were from 2010 National Alcohol Survey (N = 5,382). Surveys assessed both severe (i.e., job housing loss) moderate reduced hours/pay trouble paying rent/mortgage) attributed recession. outcomes included total annual volume, monthly...
Glutathione peroxidases (GPxs) constitutes an enzyme family which has the ability to reduce free hydrogen peroxide water and lipid hydroperoxides their corresponding alcohols, its main biological roles are protect organisms from oxidative stress-induced damage. GPxs include eight members in different tissues of body, they play essential carcinogenesis. However, prognostic value individual GPx non-small cell lung cancer (NSCLC) remains elusive.In current study, we investigated NSCLC patients...
Abstract: Erectile dysfunction (ED) is a frequent occurrence in male patients with obstructive sleep apnea syndrome (OSAS). Long‐term intermittent hypoxia (LTIH), one of the hallmarks OSAS, could mediate ED. The objective this study was to test hypothesis that increased nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity contributes ED rat responses LTIH. Healthy Sprague‐Dawley rats were randomly distributed into 4 groups: LTIH group, an apocynin (a selective NADPH...
The prognostic value of blood eosinophils in patients with acute exacerbation chronic obstructive pulmonary disease (AECOPD) remains controversial. This study aimed to evaluate whether could predict in-hospital mortality and other adverse outcomes inpatients AECOPD.The hospitalized for AECOPD were prospectively enrolled from ten medical centers China. Peripheral detected on admission, the divided into eosinophilic non-eosinophilic groups 2% as cutoff value. primary outcome was all-cause...