A5009747384- Chronic Obstructive Pulmonary Disease (COPD) Research
- Venous Thromboembolism Diagnosis and Management
- Respiratory Support and Mechanisms
- Acute Myocardial Infarction Research
- Acute Ischemic Stroke Management
- Emergency and Acute Care Studies
- Asthma and respiratory diseases
- Public Health and Nutrition
- Pneumonia and Respiratory Infections
- Amoebic Infections and Treatments
- Blood Pressure and Hypertension Studies
- Genetic and Kidney Cyst Diseases
- Congenital Anomalies and Fetal Surgery
- Parasitic infections in humans and animals
- Tissue Engineering and Regenerative Medicine
- Ultrasound in Clinical Applications
- Pleural and Pulmonary Diseases
- Diagnosis and Treatment of Venous Diseases
- Lung Cancer Diagnosis and Treatment
- Frailty in Older Adults
- Epigenetics and DNA Methylation
- Cardiac Health and Mental Health
- Phonocardiography and Auscultation Techniques
Sichuan University
2003-2025
West China Hospital of Sichuan University
2003-2025
Tianjin Medical University
2024
Abstract Background Data related to the characteristics, treatments and clinical outcomes of acute exacerbation chronic obstructive pulmonary disease (AECOPD) patients in China are limited, sex differences still a neglected topic. Methods The hospitalized for AECOPD were prospectively enrolled from ten medical centers between September 2017 July 2021. Patients some received follow-up 3 years. regarding in-hospital long-term male female included cohort analyzed compared. Results In total,...
Objectives Diabetes is a common comorbidity in COPD population. This study aimed to explore the impacts of T2DM on clinical characteristics and outcomes patients with exacerbation COPD, as well develop specified prognostic model for these patients. Methods AECOPD were enrolled from prospective, noninterventional, multicenter cohort study. Propensity score matching 1:2 ratio was performed compare prognosis between without T2DM. Predictors short-term mortality determined by logistic regression...
Sex differences in the risk of venous thromboembolism (VTE) among patients with an acute exacerbation chronic obstructive pulmonary disease (AECOPD) have so far only been sparsely described. This study aimed to investigate VTE events between male and female AECOPD determine whether any specific factors for vary sexes. We prospectively enrolled hospitalized from ten medical centers China. The primary outcome was occurrence VTE. Univariate multivariate logistic regression analyses were...
The prognostic value of blood eosinophils in patients with acute exacerbation chronic obstructive pulmonary disease (AECOPD) remains controversial. This study aimed to evaluate whether could predict in-hospital mortality and other adverse outcomes inpatients AECOPD.The hospitalized for AECOPD were prospectively enrolled from ten medical centers China. Peripheral detected on admission, the divided into eosinophilic non-eosinophilic groups 2% as cutoff value. primary outcome was all-cause...
High blood urea nitrogen (BUN) is observed in a subset of patients with acute exacerbation COPD (AECOPD) and may be linked to clinical outcome, but findings from previous studies have been inconsistent.We performed retrospective analysis prospectively enrolled the MAGNET AECOPD Registry study (ChiCTR2100044625). Receiver operating characteristic (ROC) was used determine level BUN that discriminated survivors non-survivors. Univariate multivariate Cox proportional hazards regression analyses...
Background: The Rome severity classification is an objective assessment tool for the of acute exacerbations chronic obstructive pulmonary disease (AECOPD) based on readily measurable variables but has not been widely validated. aim this study to evaluate validity in distinguishing AECOPD short-term mortality and other adverse outcomes. Methods: was applied a large multicenter cohort inpatients with AECOPD. Differences clinical features, in-hospital 60-day mortality, intensive care unit (ICU)...
Background Noninvasive mechanical ventilation (NIV) is recommended as the initial mode of to treat acute respiratory failure in patients with AECOPD. The Ventilation Outcomes (NIVO) score has been proposed evaluate prognosis AECOPD requiring assisted NIV. However, it not validated Chinese patients. Methods We used data from MAGNET Registry study, which a prospective, noninterventional, multicenter, real-world study conducted between September 2017 and July 2021 China. Data for potential risk...
Abstract Background Inpatients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) are at increased risk for venous thromboembolism (VTE); however, the prophylaxis VTE is largely underused in China. Identifying high-risk patients requiring thromboprophylaxis critical to reduce mortality and morbidity associated VTE. This study aimed evaluate compare validities Padua Prediction Score Caprini assessment model (RAM) predicting inpatients AECOPD Methods The were...
Abstract Background The morbidity and mortality among hospital inpatients with AECOPD CVDs remains unacceptably high. Currently, no risk score for predicting has been specifically developed in patients CVDs. We therefore aimed to derive validate a simple clinical assess individuals’ of poor prognosis. Study design methods evaluated prospective, noninterventional, multicenter cohort study. used multivariable logistic regression analysis identify the independent prognostic factors created...
Background: The optimal tool for risk prediction of venous thromboembolism (VTE) in inpatients with acute exacerbation chronic obstructive pulmonary disease (AECOPD) is still unknown. This study aimed to evaluate whether D-dimer could predict the VTE AECOPD compared Padua Prediction Score (PPS). Methods: Inpatients were prospectively enrolled from seven medical centers China between December 2018 and June 2020. On admission, was detected, PPS calculated each patient, incidence 2-month...
Introduction: Patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) admitted to intensive care unit (ICU) are exposed poor clinical outcomes, and no specific prognostic models available among these population. We aimed develop validate a risk score for prognosis prediction patients. Methods: This was multicenter observation study. AECOPD patients ICU were included model derivation from prospective, cohort Logistic regression analysis applied identify independent...
Venous thromboembolism (VTE) risk significantly increases in patients with an acute exacerbation of chronic obstructive pulmonary disease (AECOPD), which is characterized by enhanced inflammatory response. This study aimed to evaluate the predictive value biomarkers for VTE AECOPD.
Objective: To explore the relevant factors associated with poor prognosis in patients suffering from chronic obstructive pulmonary disease (COPD) combined embolism (PE), and investigate predictive value of simplified severity index (sPESI) score on adverse outcomes these patients. Methods: A total 168 COPD PE who were treated at West China Hospital Sichuan University January 1, 2018, to December 30, 2020 retrospectively included. Patients divided into outcome group control based occurrence...
Evidence for the prognostic impact of chest pain in acute pulmonary embolism (APE) is limited. This study aimed to assess value a Chinese cohort patients with APE. Consecutive hospitalized diagnosed APE between January 2016 and December 2019 were retrospectively enrolled followed prospectively 2 years at West China Hospital Sichuan University. The primary outcome was in-hospital all- cause mortality, while secondary outcomes included 3-month, 6-month, 2-year all-cause recurrence, mechanical...
ABSTRACT Primary cilia, functioning as crucial hubs for signal sensing and transduction, are integral to the development maintenance of homeostasis across various organs. However, their roles in tooth repair remain inadequately understood. In this study, we reveal an indispensable role primary cilia regulating regeneration teeth, primarily through regulation cell proliferation. Using cilium‐deficient mice, demonstrate that disruption ciliary leads abnormal morphology, stunted growth notably...
Abstract Background Hypocalcemia has been shown to be involved in the adverse outcomes of acute pulmonary embolism (APE). We aimed determine incremental value adding hypocalcemia, defined as serum calcium level ≤ 2.12 mmol/L, on top European Society Cardiology (ESC) prognostic algorithm, for prediction in-hospital mortality APE patients, which turn could lead optimization management. Methods This study was conducted at West China Hospital Sichuan University from January 2016 December 2019....
Objective: To study the clinical features and related factors of invasive pulmonary aspergillosis (IPA) in patients with acute exacerbation chronic obstructive disease (AECOPD). Methods: This retrospective enrolled hospitalized for AECOPD ten tertiary hospitals China from September 2017 to July 2021. IPA were included as case group, without randomly selected control group same hospitalization period using random function software Microsoft Excel 2003, at a ratio 2∶1. The characteristics,...
Abstract Background: Although intensively studied in patients with cardiovascular diseases (CVDs), the prognostic value of diastolic blood pressure (DBP) has little been elucidated acute exacerbation chronic obstructive pulmonary disease (AECOPD). This study aimed to reveal DBP AECOPD patients. Methods: Inpatients were prospectively enrolled from 10 medical centers China between September 2017 and July 2021. was measured on admission. The primary outcome all-cause in-hospital mortality;...
Objective: To investigate the risk factors associated with in-hospital mortality in hospitalized patients acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods: A total 6 668 for AECOPD seven tertiary hospitals from September 2017 to January 2021 were consecutively included, and clinical data related medical history, laboratory tests, treatment prognosis collected, divided into death group survival according whether they died during hospitalization. After univariate...
Objective: To explore the association between syncope and poor prognosis related factors of in patients with acute pulmonary embolism (APE). Methods: A total 740 first diagnosed APE treated West China Hospital Sichuan University from September 1, 2016 to December 30, 2019 were enrolled. The basic information clinical (including manifestations, complications, auxiliary examination, treatment prognosis, etc.) obtained inpatient medical records. divided into group non-syncope according whether...
Abstract Background Hypocalcemia has been shown to be involved in the adverse outcomes of acute pulmonary embolism (APE). We aimed determine incremental value adding hypocalcemia, defined as serum calcium level ≤ 2.12 mmol/L, on top European Society Cardiology (ESC) prognostic algorithm, for prediction in-hospital mortality APE patients, which turn could lead optimization management. Methods This study was conducted at West China Hospital Sichuan University from January 2016 December 2019....
Introduction We aim to explore the risk factors for in-hospital mortality and derive a prognostic model patients with APE in China. Materials methods Inpatients were enrolled from West China Hospital between January 2016 December 2019. Logistic regression analyses used develop model. Results A total of 813 subjects included this study, whom 542 training set 271 test set. Multivariable indicated that age, male, heart rate, systolic blood pressure, elevated NT-proBNP or troponin T, malignancy,...