A5100615597- Genetic and Kidney Cyst Diseases
- Epigenetics and DNA Methylation
- Retinal Diseases and Treatments
- Retinal Development and Disorders
- Renal and related cancers
- Urological Disorders and Treatments
- Tissue Engineering and Regenerative Medicine
- Acute Myeloid Leukemia Research
- Cellular transport and secretion
- Histone Deacetylase Inhibitors Research
Nankai University
2023-2024
State Key Laboratory of Medicinal Chemical Biology
2023-2024
Abstract Phagocytosis of shed photoreceptor outer segments by the retinal pigment epithelium (RPE) is essential for homeostasis. Dysregulation phagocytotic process associated with irreversible degenerative diseases. However, molecular mechanisms underlying phagocytic activity RPE cells remain elusive. In an effort to uncover proteins orchestrating function, cylindromatosis (CYLD) deubiquitinase identified as a critical regulator segment phagocytosis. CYLD‐deficient mice exhibit abnormal...
Primary cilia are distributed extensively within the corneal epithelium and endothelium. However, presence of in stroma dynamic changes roles endothelial stromal homeostasis remain largely unknown. Here, we present compelling evidence for primary stroma, both vivo vitro. We also demonstrate during development. In addition, our data show that cryoinjury triggers dramatic cilium formation endothelium stroma. Furthermore, depletion mutant mice lacking intraflagellar transport protein 88...
ABSTRACT Primary cilia, functioning as crucial hubs for signal sensing and transduction, are integral to the development maintenance of homeostasis across various organs. However, their roles in tooth repair remain inadequately understood. In this study, we reveal an indispensable role primary cilia regulating regeneration teeth, primarily through regulation cell proliferation. Using cilium‐deficient mice, demonstrate that disruption ciliary leads abnormal morphology, stunted growth notably...