A5017813437- Genetic and Kidney Cyst Diseases
- Cellular transport and secretion
- Cancer-related Molecular Pathways
- Glycosylation and Glycoproteins Research
- Galectins and Cancer Biology
- Organ Transplantation Techniques and Outcomes
- Mitochondrial Function and Pathology
- Renal and related cancers
- Ocular Surface and Contact Lens
- Carbohydrate Chemistry and Synthesis
- Hops Chemistry and Applications
- Corneal Surgery and Treatments
- Cardiac Ischemia and Reperfusion
- Ubiquitin and proteasome pathways
- Microtubule and mitosis dynamics
- Sulfur Compounds in Biology
- Autophagy in Disease and Therapy
- Genetic Syndromes and Imprinting
- Cancer, Lipids, and Metabolism
- Heme Oxygenase-1 and Carbon Monoxide
- Epigenetics and DNA Methylation
- Transplantation: Methods and Outcomes
- Kruppel-like factors research
- Wnt/β-catenin signaling in development and cancer
- Retinal Development and Disorders
Nankai University
2023-2025
State Key Laboratory of Medicinal Chemical Biology
2023-2025
Loudi Central Hospital
2024
Lanzhou University
2020-2022
TBC1D20 deficiency causes Warburg Micro Syndrome in humans, characterized by multiple eye abnormalities, severe intellectual disability, and abnormal sexual development, but the molecular mechanisms remain unknown. Here, we identify as a novel Rab11 GTPase-activating protein that coordinates vesicle transport actin remodeling to regulate ciliogenesis. Depletion of promotes accumulation deconstruction around centrosome, facilitating initiation ciliogenesis even cycling cells. Further...
OFIP, also known as KIAA0753, is a centrosomal and pericentriolar satellite protein implicated in ciliogenesis, centriolar duplication, microtubule stability. In humans, genetic mutations affecting OFIP have been the pathogenesis of Oral-Facial-Digital (OFD) Syndrome Joubert Syndrome. Ubiquitin-fold Modifier 1 (UFM1), most recently identified ubiquitin-like protein, covalently transferred to its substrates, process UFMylation. This modification has emerged key regulator various biological...
O-GlcNAcylation functions as a cellular nutrient and stress sensor participates in almost all processes. However, it remains unclear whether plays role the establishment maintenance of cell polarity, because mice lacking O-GlcNAc transferase (OGT) are embryonically lethal. Here, mild Ogt knockout mouse model is constructed important establishing maintaining polarity demonstrated. leads to severe pulmonary fibrosis dramatically promotes epithelial-to-mesenchymal transition. Mechanistic...
Age-related macular degeneration (AMD) is a major cause of visual impairment and blindness among the elderly. AMD characterized by retinal pigment epithelial (RPE) cell dysfunction. However, pathogenesis still unclear, there currently no effective treatment. Accumulated evidence indicates that oxidative stress autophagy play crucial role in development AMD. H2S an antioxidant can directly remove intracellular superoxide anions hydrogen peroxide. The purpose this study to investigate...
Our previous study indicated that exosomes derived from mouse adipose-derived mesenchymal stem cells (mADSC-Exos) alleviated the benzalkonium chloride (BAC)-induced dry eye model. However, specific active molecules in mADSC-Exos contribute to anti-dry therapy remain unidentified. In this study, we aimed investigate efficacy and mechanisms of miR-223-3p models.
Abstract Phagocytosis of shed photoreceptor outer segments by the retinal pigment epithelium (RPE) is essential for homeostasis. Dysregulation phagocytotic process associated with irreversible degenerative diseases. However, molecular mechanisms underlying phagocytic activity RPE cells remain elusive. In an effort to uncover proteins orchestrating function, cylindromatosis (CYLD) deubiquitinase identified as a critical regulator segment phagocytosis. CYLD‐deficient mice exhibit abnormal...
Carbohydrate metabolism disorders (CMDs), such as diabetes, galactosemia, and mannosidosis, cause ciliopathy-like multiorgan defects. However, the mechanistic link of cilia to CMD complications is still poorly understood. Herein, we describe significant cilium disassembly upon treatment cells with pathologically relevant aldoses rather than corresponding sugar alcohols. Moreover, environmental aldehydes are able trigger by steric hindrance effect their formyl groups. Mechanistic studies...
Primary cilia are distributed extensively within the corneal epithelium and endothelium. However, presence of in stroma dynamic changes roles endothelial stromal homeostasis remain largely unknown. Here, we present compelling evidence for primary stroma, both vivo vitro. We also demonstrate during development. In addition, our data show that cryoinjury triggers dramatic cilium formation endothelium stroma. Furthermore, depletion mutant mice lacking intraflagellar transport protein 88...
<title>Abstract</title> ATP citrate lyase (ACLY) is pivotal in de novo fatty acid synthesis. It emerges as a core metabolic enzyme implicated malignant tumor progression, especially Endometrial Cancer (EC). The present investigation revealed that Xanthohumol (XN), naturally prenylated flavonoid, novel inactivator of ACLY. XN demonstrates significant reduction synthesis and concurrent inhibition cell proliferation EC. Moreover, directly inhibits ACLY activity facilitates Smurf1-mediated...
Abstract Background: Mitochondrial transplantation (MT) is a new technology developed in recent years, which injects healthy mitochondria directly into damaged tissues or blood vessels to play therapeutic role. It has been studied many animal models of various diseases, such as myocardial ischemia, cerebral stroke, liver and lung injury, even successfully used the treatment childhood heart disease. MT can quickly improve tissue function within few minutes after injection. This fast response...