A5102022137- Fungal Plant Pathogen Control
- Epigenetics and DNA Methylation
- Synthesis and Biological Evaluation
- Ferroptosis and cancer prognosis
- Insect Pest Control Strategies
- Cancer-related gene regulation
- Gastrointestinal Tumor Research and Treatment
- Cancer Cells and Metastasis
- Synthesis and biological activity
- Cancer-related molecular mechanisms research
- Ruminant Nutrition and Digestive Physiology
- Cancer Immunotherapy and Biomarkers
- Quinazolinone synthesis and applications
- Gastric Cancer Management and Outcomes
- Synthesis and Characterization of Heterocyclic Compounds
- Insect and Pesticide Research
- Synthesis of Organic Compounds
- Hippo pathway signaling and YAP/TAZ
- Chemokine receptors and signaling
- Ion channel regulation and function
- Plant Reproductive Biology
- Synthesis and Reactivity of Heterocycles
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Plant Molecular Biology Research
- Allelopathy and phytotoxic interactions
Shihezi University
2024
Wuxi People's Hospital
2021-2023
Nanjing Medical University
2021-2023
Henan Agricultural University
2022-2023
Nankai University
2008-2012
Hebei Normal University
2009
Institute of Organic Chemistry
2008
Two series of anthranilic diamides containing acylthiourea and acylurea linkers were designed synthesized, with changed length flexibility the to compare known diamide insecticides. In total, 26 novel compounds all characterized by 1H nuclear magnetic resonance high-resolution mass spectrometry. Their insecticidal activities against oriental armyworm (Mythimna separata), mosquito larvae (Culex pipiens pallens), diamondback moth (Plutella xylostella) evaluated. The larvicidal indicated that...
BackgroundAs a common malignant disease in females, breast cancer (BCa) causes increasing numbers of cancer-related death. Collagen X alpha 1 chain (COL10A1) plays critical role the oncogenesis and progression tumors. However, systematic analysis COL10A1 BCa has not been conducted.MethodsThe expression level prognostic value were defined through Cancer Genome Atlas (TCGA) as well Kaplan-Meier plotter data respectively. The pattern was subsequently confirmed on tissue microarray (TMA) by...
With increasing demand for high-quality pork, development of green and healthy feed finishing pigs is urgently needed. In this study, the effects mechanisms mulberry paper silages on growth performance, meat quality, intestinal health were explored. Intestinal microbiota profiled, microbially produced short-chain fatty acids (SCFAs) measured. The average daily gain (ADG) conversion rate (FCR) with not significantly different from those control. Meat quality as measured by pork marbling in...
Abstract The glycosylation pathway serves as a vital regulatory mechanism in colorectal cancer. However, how genetic variants these pathways may affect the risk of cancer is still unknown. To examine relationships between and presence selected single-nucleotide polymorphisms (SNPs), 1,150 patients 1,342 controls were included this case‒control study. We found that GALNT2 rs76000797 rs11576324, GALNT6 rs67726586, FUT8 rs117497405, FUT2 rs111311275 B4GALT5 rs6125695 strongly correlated with...
To investigate the regulatory effect of ZEB1 on PD-L1 expression and pharmacodynamic effects Biochanin A malignant biological behaviors colorectal cancer (CRC).The correlation between epithelial-mesenchymal transition (EMT) score features tumor microenvironment (TME) was investigated using Cancer Genome Atlas (TCGA) dataset. The validated immunohistochemistry (IHC) staining, explored by in vitro assays. Moreover, expression, as well CRC cells, were evaluated vivo assays.EMT positively...
Abstract In search of environmentally benign insecticides with high activity, low toxicity and residue, a novel series anthranilic acid esters containing N‐ pyridylpyrazole were designed synthesized. All the compounds characterized confirmed by IR, 1 H NMR, MS elemental analysis. The single crystal structure 14d was determined X‐ray diffraction. bioassay tests showed that synthesized exhibited good insecticidal activities against Mythimna separata Walker Culex pipiens pallens .
Pembrolizumab plus trastuzumab and chemotherapy showed remarkable efficacy as first-line therapy for advanced HER2-positive gastric cancer. Pyrotinib is an irreversible pan-HER inhibitor. This single-arm, open-label phase 1 dose-escalation (1a) expansion (1b) study investigated camrelizumab, anti-PD-1 antibody, pyrotinib treatment gastroesophageal junction (G/GEJ) adenocarcinoma.Between June 2020 2022, 41 patients with previously untreated locally unresectable or metastatic G/GEJ...
The modulation of voltage‐gated calcium channels by chlorantraniliprole in the central neurones isolated from third‐instar larvae Spodoptera exigua is studied whole‐cell patch‐clamp technique. current S . identified as a high‐voltage activated Ca 2+ current. During 10‐min recording, current–voltage relationship curves are shifted negative direction 10 mV compared with control group. fact that gravity rundown treated group more apparent than demonstrates open constantly inactivated. In...
Abstract In search of environmentally benign insecticides with high activity, low toxicity and residual effects, a series novel amides (sulfonamides) containing N ‐pyridylpyrazole were designed synthesized. Their chemical structures characterized by 1 H NMR, MS elemental analysis or HRMS. The bioassay tests indicated that some these compounds exhibited moderate insecticidal activities against Mythimna separata Walker Culex pipiens pallens.
Peanut vine is a typical peanut by-product and can be used as quality roughage resource. Whole-plant corn silage commonly roughage. However, few studies have investigated the effects of diets combining whole-plant on growth performance, antioxidant capacity, meat quality, rumen fermentation microbiota beef cattle. To investigate these effects, eighty Simmental crossbred cattle (body weight, 451.27 ± 10.38 kg) approximately 14 months old were randomly divided into four treatments for 90-day...
A new kind of anthranilic diamides containing 5,7-dimethyl[1,2,4]triazolo[1,5- a]pyrimidine were designed and synthesised. Their structures identified by means elemental analysis, IR, 1 H NMR MS spectra. As the key intermediate, ethyl a]pyrimidine-2-carboxylate (7) was synthesised applying microwave irradiation.
Esophageal cancer is one of the most unknown and deadliest cancers in world. Although recent studies have identified some mutations linked to development squamous cell carcinoma esophagus (ESCC), specific role HomeoboxC10 (HOXC10) pathogenesis still requires further investigation.Agilent mRNA single-channel gene expression was employed identify genome-wide signatures ESCC. These were also verified using qRT-PCR, immunohistochemical staining as well Western blot. The biological functions...
In this paper, the role of plasma membrane (PM) H+-ATPase in extracellular calmodulin (CaM)-promoted pollen germination and tube growth Arabidopsis thaliana was investigated. Pollen germination, rate, free cytosolic Ca2+ concentration ([Ca2+]cyt) channel activity PM cells were measured. response to fusicoccin or CaM treatment, vitro [Ca2+]cyt a hyperpolarization-activated Ca2+-permeable increased. Sodium vanadate inhibited promotion these parameters by CaM. The results suggest that may be...
<title>Abstract</title> ATP citrate lyase (ACLY) is pivotal in de novo fatty acid synthesis. It emerges as a core metabolic enzyme implicated malignant tumor progression, especially Endometrial Cancer (EC). The present investigation revealed that Xanthohumol (XN), naturally prenylated flavonoid, novel inactivator of ACLY. XN demonstrates significant reduction synthesis and concurrent inhibition cell proliferation EC. Moreover, directly inhibits ACLY activity facilitates Smurf1-mediated...
356 Background: The combination of PD-1 and HER2 blockades showed potential benefit for patients with HER2-positive gastric cancer. This study aimed to investigate the safety efficacy camrelizumab plus pyrotinib chemotherapy in first-line setting or gastroesophageal junction (G/GEJ) adenocarcinoma. Methods: phase I, open-label, clinical trial (ChiCTR2000029717) included dose-escalation dose-expansion cohorts. Patients aged 18 older G/GEJ cancer were enrolled. In phase, administrated...
Mammalian Ste20-like kinase 2 (MST2) is a core component of the Hippo pathway and plays an important role in regulating cell apoptosis, proliferation cycle progression, but it has rarely been studied invertebrates, especially crustaceans. In this study, MST2 gene penaeus japonicus shrimp was characterized. A 2111 bp long nucleotide sequence encoding 690 amino acids obtained. The molecular weight protein 78.47222 kDa. bioinformatics analysis indicated that S_TK-c (Ser/Thr kinase) domain SARAH...
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 200 leading journals. To access of an article which published elsewhere, please select “Full Text” option. The original trackable via the “References”
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 200 leading journals. To access of an article which published elsewhere, please select “Full Text” option. The original trackable via the “References”