A5101806227- Cancer Immunotherapy and Biomarkers
- Lung Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Treatments and Mutations
- RNA modifications and cancer
- Immunotherapy and Immune Responses
- Cancer Cells and Metastasis
- Immune Cell Function and Interaction
- Cancer-related molecular mechanisms research
- HER2/EGFR in Cancer Research
- T-cell and B-cell Immunology
- Esophageal Cancer Research and Treatment
- MicroRNA in disease regulation
- Gastric Cancer Management and Outcomes
- Traditional Chinese Medicine Analysis
- Consumer Attitudes and Food Labeling
- Liver Disease Diagnosis and Treatment
- Atherosclerosis and Cardiovascular Diseases
- Cardiovascular Health and Risk Factors
- Color perception and design
- Traditional Chinese Medicine Studies
- Coffee research and impacts
- Textile materials and evaluations
- Advanced Drug Delivery Systems
- Ferroptosis and cancer prognosis
Center for Disease Control
2024
Xuzhou Medical College
2005-2024
Shandong University
2018-2024
Fudan University Shanghai Cancer Center
2024
Affiliated Hospital of Xuzhou Medical College
2024
Chongqing University
2024
Harbin Medical University
2020-2021
Fourth Affiliated Hospital of Harbin Medical University
2020-2021
Sichuan University
2021
West China Hospital of Sichuan University
2021
Two major treatment strategies employed in non-small cell lung cancer, NSCLC, are tyrosine kinase inhibitors, TKIs, and immune checkpoint ICIs. The choice of strategy is based on heterogeneous biomarkers that can dynamically change during therapy. Thus, there a compelling need to identify comprehensive be used longitudinally help guide therapy choice. Herein, we report 18F-FDG-PET/CT-based deep learning model, which demonstrates high accuracy EGFR mutation status prediction across patient...
Abstract Background Current treatment options for human epidermal growth factor receptor 2 (HER2)‐overexpressing gastric cancer at third‐line have shown limited clinical benefit. Further, there is no specific HER2 immunohistochemistry (IHC) 2+ and fluorescence in‐situ hybridization‐negative patients. Here, we report the efficacy safety of a novel anti‐HER2 antibody RC48 patients with HER2‐overexpressing, advanced or gastroesophageal junction cancer. Methods Patients HER2‐overexpressing (IHC...
It has been acknowledged that circulating tumor cells (CTCs) are promising biomarkers in liquid biopsy for cancer diagnosis and prognosis. However, the relationship between CTC number gastric scarcely quantitatively investigated. Moreover, single criterion of epithelial cell adhesion molecule (EpCAM) antibody/aptamer to specifically recognize CTCs cannot be universally applied clinical applications, as it fails EpCAM-negative CTCs. Herein, we propose simple, low-cost, dual-aptamer (EpCAM...
Abstract Colon cancer is a common and deadly human digestive tract malignant tumor with poor prognosis. Immunotherapy has elicited tremendous success as treatment modality for multiple solid tumors. Triptolide extracted from the traditional Chinese medicine Tripterygium wilfordii Hook. F which shows various pharmacological actions including antitumor, anti‐inflammatory, antimicrobial, antifibrosis, antirheumatic. However, influence of triptolide on remodeling immune microenvironment still...
Circulating tumor cells (CTC) have been represented by different phenotypes due to the epithelial–mesenchymal transition (EMT), which are epithelial CTC (E-CTC), mesenchymal (M-CTC), and mixed (epithelial, mesenchymal) (EM-CTC). Limited work has systematically discussed associations of number, especially proportions E-CTC, M-CTC, EM-CTC in total CTC, with colorectal cancer (CRC) progressions via a simple method high performances. To achieve this goal, paper presents fabrication novel...
Abstract Long noncoding RNAs (lncRNAs) are recently recognized as noteworthy regulators of different tumors, counting gastric cancer (GC). Lately, long intergenic RNA (LINC) 00665 has been verified to display significant parts in several cancers. Be that it may, its role and mechanism GC movement still stay uninvestigated. As now, we observed LINC00665 was obviously cells (MKN28, BGC‐823, SGC7‐901, AGS, HGC‐27) comparison GES‐1 cells, which identified human normal epithelial cells. Then,...
Pembrolizumab plus trastuzumab and chemotherapy showed remarkable efficacy as first-line therapy for advanced HER2-positive gastric cancer. Pyrotinib is an irreversible pan-HER inhibitor. This single-arm, open-label phase 1 dose-escalation (1a) expansion (1b) study investigated camrelizumab, anti-PD-1 antibody, pyrotinib treatment gastroesophageal junction (G/GEJ) adenocarcinoma.Between June 2020 2022, 41 patients with previously untreated locally unresectable or metastatic G/GEJ...
Lung cancer remains a big threat to human health. Growing evidence has reported the crucial regulatory effect of lncRNAs on NSCLC progression. Nevertheless, detailed function lncRNA MBNL1-AS1 involved in development is poorly known. In our research, we confirmed that was significantly reduced patient tissues and cells. Meanwhile, overexpression obviously repressed A549 H1975 cell proliferation, blocked cycle inhibited migration invasion. Moreover, apoptosis increased by MBNL1-AS1. Then,...
Background Determining the status of lymph node (LN) metastasis in rectal cancer patients preoperatively is crucial for treatment option. However, diagnostic accuracy current imaging methods low. Purpose To develop and test a model predicting metastatic LNs based on clinical data MR images to improve diagnosis LNs. Study type Retrospective. Subjects In all, 341 with histologically confirmed were divided into one training set (120 cases) three validation sets (69, 103, 49 cases). Field...
How to recognize precisely epidermal growth factor receptor (EGFR) mutation in lung cancer patients owns great clinical requirement. In this study, 1575 radiomics features were extracted from PET images of 75 based on contrast agents such as 18F-MPG and 18F-FDG. The Mann-Whitney U test was used for single analysis, the Least Absolute Shrinkage Selection Operator (Lasso) Regression feature screening, then classification models established by using support vector machines ten-fold...
(1) Background: Chemotherapy-induced cognitive impairment (CICI) is often observed in cancer patients and impairs their life quality. Grape-seed-orientated procyanidin has been shown to have anti-inflammatory neuroprotective effects, yet its effects preventing CICI not investigated. (2) Method: Adult male mice received 2.3 mg/kg cisplatin or saline injections for three cycles consisting of five daily followed by 5 days rest. Procyanidin was administered 1 h prior treatment. Cognitive...
Angina pectoris (AP) with coronary heart disease (CHD) is one of the common cardiovascular diseases in clinical practice, which can be classified as “chest paralysis” Chinese medicine according to its symptoms, and it described many ancient documents. Ancient believes that main pathogenesis poor blood flow leading paralysis veins, so often treated by activating removing stasis. In this study, 120 patients AP CHD Qi stagnation stasis type were randomly divided into observation (n = 60)...
<title>Abstract</title> Older adults in rural areas lack vaccination knowledge and health awareness, resulting a low willingness to vaccinate. To examine the integration of education with ecological momentary intervention (EMI) older develop strategies increase rates reduce burden respiratory infections this vulnerable group, we conducted community trial using cluster-randomized design villages Shandong Province, China, between October 2023 May 2024. The were randomly allocated EMI or...
// Fan 1, 2 , Zhengqiu Zhu 3 Chao Gao Yun Liu 1 Baoqing Wang Ziquan and Jifeng Feng Department of Chemotherapy, Nanjing Medical University Affiliated Cancer Hospital, Jiangsu Institute Research, 210009, China The No.2 Hospital Xuzhou University, 221000, Correspondence to: Feng, email: medfjif@sina.com Keywords: lncRNA, lung cancer, prognosis Received: July 06, 2017 Accepted: August 29, Published: September 20, ABSTRACT Many different long non-coding RNAs (lncRNAs) have been reported to be...