A5027960464- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging Techniques and Applications
- Radiopharmaceutical Chemistry and Applications
- Lung Cancer Diagnosis and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Peptidase Inhibition and Analysis
- Advanced X-ray and CT Imaging
- Lung Cancer Treatments and Mutations
- Medical Imaging and Pathology Studies
- Protease and Inhibitor Mechanisms
- Pancreatic and Hepatic Oncology Research
- Lung Cancer Research Studies
- HER2/EGFR in Cancer Research
- Lymphoma Diagnosis and Treatment
- AI in cancer detection
- Cardiac Structural Anomalies and Repair
- Sarcoma Diagnosis and Treatment
- Glycosylation and Glycoproteins Research
- Cancer Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Advanced Radiotherapy Techniques
- Ultrasound and Hyperthermia Applications
- Gastric Cancer Management and Outcomes
- Ultrasound Imaging and Elastography
- Renal cell carcinoma treatment
Fourth Hospital of Hebei Medical University
2016-2025
Hebei Medical University
2016-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2006-2022
Shijiazhuang University
2016-2022
Moffitt Cancer Center
2009-2013
Academy of Medical Sciences
2011
Peking Union Medical College Hospital
2006-2011
Academia Sinica
2011
University of South Florida
2009
Two major treatment strategies employed in non-small cell lung cancer, NSCLC, are tyrosine kinase inhibitors, TKIs, and immune checkpoint ICIs. The choice of strategy is based on heterogeneous biomarkers that can dynamically change during therapy. Thus, there a compelling need to identify comprehensive be used longitudinally help guide therapy choice. Herein, we report 18F-FDG-PET/CT-based deep learning model, which demonstrates high accuracy EGFR mutation status prediction across patient...
Patients with radioactive iodine-refractory differentiated thyroid cancer (RAIR-DTC) have a poor prognosis and limited treatment options.
In recent years, immune checkpoint inhibitor (ICI) therapy has greatly changed the treatment prospects of patients with non-small cell lung cancer (NSCLC). Among available ICI strategies, programmed death-1 (PD-1)/programmed death ligand-1 (PD-L1) inhibitors are most widely used worldwide. At present, immunohistochemistry (IHC) is main method to detect PD-L1 expression levels in clinical practice. However, given that IHC invasive and cannot reflect dynamically real time, it great...
[177Lu]Lu-PSMA-617 (Pluvicto), a new radioligand therapy that targets prostate-specific membrane antigen (PSMA), has been approved to treat metastatic castration-resistant prostate cancer (mCRPC). However, the real-world safety profile of not systemically evaluated. Adverse event reports for were retrieved from April 2022 June 2024 The Food and Drug Administration Event Reporting System (FAERS) database. Disproportionality analysis was conducted by four algorithms: reporting odds ratio...
A 56-year-old woman underwent surgery for clear cell renal carcinoma (ccRCC) 8 years ago. The patient incidentally discovered 2 foci in the body and tail of pancreas by abdominal ultrasound during follow-up. MRI disclosed lesions with central inhomogeneous enhancement restricted diffusion. showed no 18F-FDG uptake but had mild to moderate 68Ga-FAPI accumulation PET/CT images. Postoperative pathology immunohistochemical analysis confirmed metastatic ccRCC pancreas. might be a useful tool...
Integrin αvβ6 is highly expressed in pancreatic cancer, making it an ideal target for molecular imaging diagnosis. Multimerization considered effective strategy to increase the accumulation of probes tumors. Here, we synthesized monomeric and dimeric αvβ6-targeting probes, labeled with 68Ga, designated them [68Ga]Ga-αvβ6-1 [68Ga]Ga-αvβ6-2, respectively. Both vitro vivo studies were conducted using human cancer BxPC-3 cells tumor-bearing mice. Additionally, positron emission...
// Di Ma 1, * , Zheng Wang 2, Lin Yang 3 Xinlin Mu 4 Yan 1 Xinming Zhao 5 Junling Li Dongmei 6 Department of Medical Oncology, Cancer Institute & Hospital, Chinese Academy Sciences, Beijing, China 2 Pathology, Beijing Hospital the Ministry Health, Respiratory and Critical Care Medicine, Peking University People's Diagnostic Radiology, Key Laboratory Carcinogenesis Translational Research (Ministry Education), Institute, These authors have contributed equally to this work Correspondence to:...
Purpose: Immunohistochemistry (IHC) is the main method to detect human epidermal growth factor receptor 2 (HER2) expression levels. However, IHC invasive and cannot reflect HER2 status in real time. The aim of this study was construct verify three types radiomics models based on 18F-fuorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) imaging evaluate predictive ability for patients with gastric cancer (GC). Patients Methods: A total 118 GC were enrolled...
Objective The objective of this study is to evaluate the effectiveness 68 Ga-FAPI-04 PET/computed tomography (CT) for diagnosis primary and metastatic gastric cancer colorectal lesions as compared with 18 F-FDG PET/CT. Materials methods Fifty-nine patients who underwent both initial staging or restaging were enrolled. Histopathological findings clinical imaging follow-up used reference standard. diagnostic performance TNM two tracers calculated compared. maximum standardized uptake value...
Objective: The objective of the study was to analyze metabolic features and distribution normal pancreas pancreatic adenocarcinoma while determining biomarker cancerous process. Methods: Twenty-seven control 29 patients underwent breath-hold 3-T proton magnetic resonance spectroscopy. ratios lipid (lipid/InW), choline-containing compounds (CCCs/InW), fatty acids (FAs/InW) nonsaturated internal water (InW) head body-tail region, with noncancerous regions in adenocarcinoma, were calculated....
Pal T, Stowe C, Cole A, Lee J‐H, Zhao X, Vadaparampil S. Evaluation of phone‐based genetic counselling in African American women using culturally tailored visual aids. Genetic (GC) services for inherited breast and ovarian cancer (HBOC) are underutilized by (AA) women. We sought to evaluate factors associated with knowledge gain a sample AA diagnosed early‐onset cancer, whom GC HBOC was provided, targeted aid (GCA). Through registry‐based study, offered ≤50. A questionnaire assess about...
Objectives This study aimed to evaluate the diagnostic value of acoustic radiation force impulse (ARFI) imaging and strain elastography in differentiating malignant from benign thyroid nodules. Methods included 128 patients (104 female 24 male; mean age ± standard deviation, 48 11 years; range, 23–76 years) with 152 pathologically proven Conventional sonography, ratio (SR) elastography, virtual touch tissue (VTI) grade, quantification (shear wave velocity [SWV]) ARFI data were generated for...
Epidermal growth factor receptor (EGFR) is overexpressed in many carcinomas and remains a prime target for diagnostic therapeutic applications. There need to develop noninvasive methods identify the subset of patients that most likely benefit from EGFR-targeted treatment. Noninvasive imaging EGFR messenger RNA (mRNA) expression may be useful approach. The aim this study was method preparation single-photon-emitting probes, (99m)Tc-labeled mRNA antisense peptide nucleic acid (PNA)...
The aim of this study was to assess the diagnostic value acoustic radiation force impulse (ARFI) imaging for differentiating superficial lymph nodes. Virtual touch tissue (VTI) grade and shear wave velocity (SWV) were analyzed compared in 97 patients (65 women, 32 men; mean age, 49 y; range, 23–72 y) with nodes [23 chronic nonspecific reactive (CLNs), 38 metastatic (MLNs), 36 blood lymphatic system diseases (BLLNs)]. elastography characteristics CLNs, MLNs, BLLNs using nonparametric...
Abstract Background Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin in adults. Standard treatment includes chemoimmunotherapy with R-CHOP or similar regimens. Despite advancements, many patients DLBCL experience refractory disease relapse. While baseline 18 F-fluorodeoxyglucose positron emission tomography ( F-FDG PET) parameters have shown promise predicting survival, they may not fully capture lesion heterogeneity. This study aimed to assess prognostic value...