Xiaoshan Chen

ORCID: 0009-0007-2972-6998
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About
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Research Areas
  • Radiomics and Machine Learning in Medical Imaging
  • MRI in cancer diagnosis
  • Hepatocellular Carcinoma Treatment and Prognosis
  • Gastrointestinal Tumor Research and Treatment
  • Gastric Cancer Management and Outcomes
  • Peptidase Inhibition and Analysis
  • Gastrointestinal disorders and treatments
  • Effects and risks of endocrine disrupting chemicals
  • Protease and Inhibitor Mechanisms
  • Retinal Imaging and Analysis
  • Fish biology, ecology, and behavior
  • Aquaculture Nutrition and Growth
  • Medical Imaging Techniques and Applications
  • Traditional Chinese Medicine Analysis
  • Medical Image Segmentation Techniques
  • Medical Imaging and Pathology Studies
  • Advanced X-ray and CT Imaging
  • Fibroblast Growth Factor Research
  • Digital Imaging for Blood Diseases
  • Influenza Virus Research Studies
  • Patient Satisfaction in Healthcare
  • Natural product bioactivities and synthesis
  • Liver Disease Diagnosis and Treatment
  • Primate Behavior and Ecology
  • AI in cancer detection

Hebei Medical University
2023-2025

Fourth Hospital of Hebei Medical University
2023-2025

Zhongshan Hospital
2022-2025

Fudan University
2019-2025

Southern Medical University
2022-2025

World Health Organization
2025

Sichuan University
2024

West China Hospital of Sichuan University
2024

The First Affiliated Hospital, Sun Yat-sen University
2022-2024

Sun Yat-sen University
2022-2024

The African turquoise killifish is an exciting new vertebrate model for aging studies. A significant challenge any organism the control over its diet in space and time. To address this challenge, we created automated networked fish feeding system. Our feeder designed to be open-source, easily transferable, built from widely available components. Compared manual feeding, our system highly precise flexible. As a proof of concept flexibility these feeders, define favorable regimen growth...

10.7554/elife.69008 article EN cc-by eLife 2022-11-10

<title>Abstract</title> Background Influenza vaccination rates remain suboptimal globally, particularly in China, highlighting the need for effective, low-cost interventions. This randomized controlled trial aimed to evaluate effectiveness of a 30-second Rapid Verbal Persuasion intervention promoting influenza uptake among individuals visiting centers China. Methods The study was conducted from November 13 December 7, 2023, across eight primary healthcare three Chinese cities (Ningbo,...

10.21203/rs.3.rs-5828050/v1 preprint EN cc-by Research Square (Research Square) 2025-02-04

The optimization of regularization strategies in computed tomography (CT) iterative reconstruction may allow for a reduced dose (RD) without compromising image quality, thus the diagnostic ability RD imaging must be considered, especially low-contrast lesions. In this study, we evaluated quality and performance 50% CT colorectal liver metastasis (CRLM) with artificial intelligence model-based (AIIR) standard-dose (SD) hybrid (HIR). prospective consecutive participants pathologically proven...

10.21037/qims-24-1570 article EN Quantitative Imaging in Medicine and Surgery 2025-02-24

Integrin αvβ6 is highly expressed in pancreatic cancer, making it an ideal target for molecular imaging diagnosis. Multimerization considered effective strategy to increase the accumulation of probes tumors. Here, we synthesized monomeric and dimeric αvβ6-targeting probes, labeled with 68Ga, designated them [68Ga]Ga-αvβ6-1 [68Ga]Ga-αvβ6-2, respectively. Both vitro vivo studies were conducted using human cancer BxPC-3 cells tumor-bearing mice. Additionally, positron emission...

10.1021/acs.molpharmaceut.5c00051 article EN Molecular Pharmaceutics 2025-04-07

Image segmentation is fundamental task for medical image analysis, whose accuracy improved by the development of neural networks. However, existing algorithms that achieve high-resolution performance require input, resulting in substantial computational expenses and limiting their applicability field. Several studies have proposed dual-stream learning frameworks incorporating a super-resolution as auxiliary. In this paper, we rethink these reveal feature similarity between tasks insufficient...

10.1109/tpami.2023.3322735 article EN cc-by-nc-nd IEEE Transactions on Pattern Analysis and Machine Intelligence 2023-10-09

Objective The objective of this study is to evaluate the effectiveness 68 Ga-FAPI-04 PET/computed tomography (CT) for diagnosis primary and metastatic gastric cancer colorectal lesions as compared with 18 F-FDG PET/CT. Materials methods Fifty-nine patients who underwent both initial staging or restaging were enrolled. Histopathological findings clinical imaging follow-up used reference standard. diagnostic performance TNM two tracers calculated compared. maximum standardized uptake value...

10.1097/mnm.0000000000001845 article EN Nuclear Medicine Communications 2024-04-29

Objective: Ischemic stroke leads to cellular death and tissue damage by depriving the areas of glucose oxygen supplies. The effective treatment remains a challenge for modern medicine. This study used an oxygen-glucose deprivation (OGD) model human umbilical vein endothelial cells (HUVECs) mimic ischemic injuries explored role mechanism intelectin-1. Methods: Intelectin-1 was transduced into HUVECs using lentiviral vector. To examine potential involvement PI3K/Akt signaling in...

10.3389/fneur.2019.00383 article EN cc-by Frontiers in Neurology 2019-04-16

Hard exudates (HE) is the most specific biomarker for retina edema. Precise HE segmentation vital disease diagnosis and treatment, but automatic challenged by its large variation of characteristics including size, shape position, which makes it difficult to detect tiny lesions lesion boundaries. Considering complementary features between super-resolution tasks, this paper proposes a novel hard method named SSMAF with an auxiliary task, brings in helpful detailed boundaries detection....

10.1109/bibm55620.2022.9995545 article EN 2021 IEEE International Conference on Bioinformatics and Biomedicine (BIBM) 2022-12-06

Introduction As direct-to-consumer teleconsultation (hereafter referred to as ‘teleconsultation’) has gained popularity, an increasing number of patients have been leaving online reviews their experiences. These can help guide in identifying doctors for teleconsultation. However, few studies examined the validity assessing quality against a gold standard. Therefore, we aim use unannounced standardised (USPs) validate both technical and patient-centred teleconsultations. We hypothesise that...

10.1136/bmjopen-2023-071783 article EN cc-by-nc BMJ Open 2023-05-01

Abstract Objective The development of non-invasive methods for evaluating lymph node metastasis (LNM) preoperatively in gastric cancer (GC) is necessary. In this study, we developed a new radiomics model combining features from the tumor and peri-tumor regions predicting LNM prognoses. Methods This was retrospective observational study. two cohorts patients with GC treated Zhongshan Hospital Fudan University (Shanghai, China) were included. total, 193 assigned to internal training/validation...

10.1093/gastro/goac080 article EN cc-by-nc Gastroenterology report 2022-12-30

Introduction Sepsis delays wound healing owing to uncontrolled inflammation. A single perioperative dose of dexamethasone is widely used because its anti-inflammatory effects. However, the effects on in sepsis remain unclear. Methods We discuss methods obtain curves and explore safe dosage range for mice with or without sepsis. saline LPS intraperitoneal injection was applied C57BL/6 mice. After 24 hours, received a DEX full-thickness, dorsal wounding operation. Wound observed by image...

10.3389/fsurg.2023.927168 article EN cc-by Frontiers in Surgery 2023-04-11

This study aimed to predict therapeutic efficacy among diffuse large B-cell lymphoma (DLBCL) after R-CHOP (-like) therapy using baseline

10.1089/cbr.2024.0115 article EN Cancer Biotherapy and Radiopharmaceuticals 2024-09-04

Abstract Jieyu Anshen Granule is a traditional Chinese medicine prescription used for depression and primarily comprises five herbal medicines: Zhizi, Chaihu, Zhigancao, Danggui, Yuanzhi. This study established medicine‐specific library using emerging ultra‐high‐performance liquid chromatography‐quadrupole‐orbitrap‐tandem mass spectrometry analysis. Through comparison, the has fulfilled isomers distinction. As result, 47 compounds were simultaneously putatively identified from Granule,...

10.1002/open.202400046 article EN cc-by ChemistryOpen 2024-11-21

Mesenchymal stem cells (MSCs) have great potential for the repair and regeneration of bone fracture, but their optimal origins remain controversial.Bone marrow-MSCs (BM-MSCs) bone-bone (B-BM-MSCs) were isolated from 12 SD rats, morphology, MSC-associated markers, proliferative capacity these compared using an inverted microscope, flow cytometry, CCK-8 assays, respectively. After 14 days osteoblastic induction, osteoblast phenotypes detected by ALP calcium nodule staining, expression BMP-2...

10.1186/s13018-019-1346-z article EN cc-by Journal of Orthopaedic Surgery and Research 2019-09-03
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