A5044828990- Plant Pathogens and Fungal Diseases
- Plant-Microbe Interactions and Immunity
- Fungal and yeast genetics research
- Plant Disease Resistance and Genetics
- Thyroid Cancer Diagnosis and Treatment
- Genetic Associations and Epidemiology
- Genomics and Phylogenetic Studies
- Curcumin's Biomedical Applications
- Fungal Biology and Applications
- Autophagy in Disease and Therapy
- Endoplasmic Reticulum Stress and Disease
- Garlic and Onion Studies
- Epigenetics and DNA Methylation
- Mycorrhizal Fungi and Plant Interactions
- Ferroptosis and cancer prognosis
- Thyroid Disorders and Treatments
- Cancer, Lipids, and Metabolism
- Genetic Mapping and Diversity in Plants and Animals
- Plant Pathogens and Resistance
- Wheat and Barley Genetics and Pathology
- Genetic Syndromes and Imprinting
- Microbial Natural Products and Biosynthesis
- Retinoids in leukemia and cellular processes
- Bioinformatics and Genomic Networks
- Biomarkers in Disease Mechanisms
ZheJiang Academy of Agricultural Sciences
2013-2025
Institute of Plant Protection
2021-2025
Key Laboratory of Nuclear Radiation and Nuclear Energy Technology
2020-2025
Fujian Agriculture and Forestry University
2015-2024
Hebei Science and Technology Department
2023-2024
Nanjing University of Science and Technology
2023
Ministry of Agriculture and Rural Affairs
2022
BOE Technology Group (China)
2021
Vanderbilt University
2018-2021
Zhejiang A & F University
2021
Ustilaginoidea virens (Cooke) Takah is an ascomycetous fungus that causes rice false smut, a devastating emerging disease worldwide. Here we report 39.4 Mb draft genome sequence of U. encodes 8,426 predicted genes. The has ~25% repetitive sequences have been affected by repeat-induced point mutations. Evolutionarily, close to the entomopathogenic Metarhizium spp., suggesting potential host jumping across kingdoms. possesses reduced gene inventories for polysaccharide degradation, nutrient...
Summary We identified the M agnaporthe oryzae avirulence effector A vr P i9 cognate to rice blast resistance gene by comparative genomics of requisite strains derived from a sequential planting method. AvrPi9 encodes small secreted protein that appears localize in biotrophic interfacial complex and is translocated host cell during infection. forms tandem array with its paralogue proximal centromeric region chromosome 7. expressed highly at early stages initiation disease. Virulent isolate...
We examined the genomes of 100 isolates Magnaporthe oryzae (Pyricularia oryzae), causal agent rice blast disease. grouped current field populations M. into three major globally distributed groups. A genetically diverse group, clade 1, which may represent a group closely related lineages, contains both mating types. Two well-separated clades, clades 2 and 3, appear to have arisen as clonal lineages distinct from clade. Examination genes involved in pathways identified clade-specific...
Patients with radioactive iodine-refractory differentiated thyroid cancer (RAIR-DTC) have a poor prognosis and limited treatment options.
Background: Thyroid cancer is the most common endocrine tumor. Our previous studies have demonstrated that curcumin can induce apoptosis in human papillary thyroid carcinoma BCPAP cells. However, underlined mechanism has not been clearly elucidated. Endoplasmic reticulum (ER) a major organelle for synthesis, maturation, and folding proteins as well large store Ca2+. Overcoming chronically activated ER stress by triggering pro-apoptotic pathways of unfolded protein response (UPR) novel...
Summary Despite the importance of host–microbe interactions in natural ecosystems, agriculture and medicine, impact long‐term (especially decades or longer) microbial colonization on dynamics host genomes is not well understood. The vegetable crop ‘Jiaobai’ with enlarged edible stems was domesticated from wild Zizania latifolia (Oryzeae) approximately 2000 years ago as a result persistent infection by fungal endophyte, Ustilago esculenta . Asexual propagation via infected rhizomes only means...
One major threat to global food security that requires immediate attention, is the increasing incidence of host shift and expansion in growing number pathogenic fungi emergence new pathogens. The more alarming because, yield quality quantity improvement efforts are encouraging cultivation uniform plants with low genetic diversity increasingly susceptible emerging However, influence genome differentiation on pathogen its contribution adaptability still obscure. Here, we compared sequence 6...
Abstract Background Although APOBEC-mutational signature is found in tumor tissues of multiple cancers, how a common germline APOBEC3A/B deletion affects the mutational remains unclear. Methods Using data from 10 cancer types generated as part TCGA, we performed integrative genomic and association analyses to assess inter-relationship expressions for isoforms APOBEC3A APOBEC3B , signature, deletions, neoantigen loads, infiltration lymphocytes (TILs). Results We that expression level isoform...
Capsaicin inhibits metastasis of human papillary thyroid carcinoma BCPAP cells through modulation the TRPV1 channel.
Oxidative stress has been implicated in both normal aging and various neurodegenerative disorders it may be a major cause of neuronal death. Chaperone-mediated autophagy (CMA) targets selective cytoplasmic proteins for degradation by lysosomes protects neurons against extracellular stimuli including oxidative stress. MEF2A (myocyte enhancer factor 2A), key transcription factor, primary from stress-induced cell damage. However, the precise mechanisms how protein stability transcriptional...
Curcumin induces DNA damage, resulting in G2/M cell cycle arrest and following apoptosis BCPAP cells <italic>via</italic> activation of an ATM-Chk2-Cdc25C-Cdc2 cascade.
Macroautophagy/autophagy is an evolutionarily conserved biological process among eukaryotes that degrades unwanted materials such as protein aggregates, damaged mitochondria and even viruses to maintain cell survival. Our previous studies have demonstrated MoVast1 acts autophagy regulator regulating autophagy, membrane tension, sterol homeostasis in rice blast fungus. However, the detailed regulatory relationships between VASt domain proteins remain unsolved. Here, we identified another...