A5001731399- Cancer Immunotherapy and Biomarkers
- Pediatric Hepatobiliary Diseases and Treatments
- Gallbladder and Bile Duct Disorders
- Cancer Genomics and Diagnostics
- Pancreatic and Hepatic Oncology Research
- Cancer Cells and Metastasis
- HER2/EGFR in Cancer Research
- Genetic factors in colorectal cancer
- Cancer Mechanisms and Therapy
- Intestinal Malrotation and Obstruction Disorders
- Congenital Anomalies and Fetal Surgery
- Reproductive System and Pregnancy
- Biological Stains and Phytochemicals
- Cancer Research and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Clinical Nutrition and Gastroenterology
- Infant Nutrition and Health
- Enhanced Recovery After Surgery
- Skin Protection and Aging
- Single-cell and spatial transcriptomics
- Colorectal Cancer Treatments and Studies
- Immune Cell Function and Interaction
- Esophageal Cancer Research and Treatment
- Pituitary Gland Disorders and Treatments
- Breastfeeding Practices and Influences
Sun Yat-sen University
2024
The First Affiliated Hospital, Sun Yat-sen University
2024
Sun Yat-sen University Cancer Center
2024
Guangdong Academy of Medical Sciences
2022
Guangdong Provincial People's Hospital
2021-2022
Children's Hospital of Zhejiang University
2019-2022
Abstract Background Current treatment options for human epidermal growth factor receptor 2 (HER2)‐overexpressing gastric cancer at third‐line have shown limited clinical benefit. Further, there is no specific HER2 immunohistochemistry (IHC) 2+ and fluorescence in‐situ hybridization‐negative patients. Here, we report the efficacy safety of a novel anti‐HER2 antibody RC48 patients with HER2‐overexpressing, advanced or gastroesophageal junction cancer. Methods Patients HER2‐overexpressing (IHC...
Biliary atresia (BA) is a devastating fibroinflammatory biliary disease that the leading indication for pediatric liver transplants worldwide. Although cholangiocytes are primary target cells, pathogenic mechanisms involving remain elusive. Here, we aimed to characterize role of in BA.
Abstract Immune checkpoint inhibitor (ICI)‐based therapies have shown promising advances for the first‐line treatment of advanced or metastatic esophageal cancer (EC). However, few studies concerning identification patients who achieve durable response from ICIs been previously reported. In present study, pre‐ and on‐treatment plasma circulating tumor DNA (ctDNA) were analyzed in 10 with squamous cell (ESCC) receiving chemoimmunotherapy. Patients decreased molecular burden index (mTBI)...
Apatinib is a selective inhibitor of vascular endothelial growth factor receptor-2. Despite encouraging anticancer activity in different cancer types, some patients may not benefit from apatinib treatment. Herein, we characterized genomic profiles colorectal (CRC) to explore predictive biomarkers at molecular level. We retrospectively recruited 19 CRC receiving as third-line Tissue samples before treatment were collected and subjected profiling using targeted sequencing panel covering 520...
Objective To investigate the expression of Smad3 (mothers against decapentaplegic homolog 3) protein in postnecrotizing enterocolitis stricture and its possible mechanism action. Methods We used immunohistochemistry to detect characteristics nuclear factor kappa B (NF-κB) proteins human stricture. cultured IEC-6 (crypt epithelial cells rat small intestine) vitro inhibited using siRNA technique. Quantitative PCR, western blotting, ELISA were changes transforming growth factor-β1 (TGF-β1),...
To summarize the clinical characteristics and treatment of type Ⅲ-b congenital intestinal atresia (CIA).The data 12 CIA treated in Children's Hospital Zhejiang University School Medicine from January 2015 to December 2017 were analyzed retrospectively.Of patients diagnosed as operation, was refused during operation by their parents 2 cases. For one child, only proximal intestine partly resected first dilatation dysplasia duodenum total sutured second child had postoperative obstruction. due...