A5103234534- Helicobacter pylori-related gastroenterology studies
- Cancer-related molecular mechanisms research
- Parkinson's Disease Mechanisms and Treatments
- Sleep and Wakefulness Research
- Tuberculosis Research and Epidemiology
- Eosinophilic Esophagitis
- Restless Legs Syndrome Research
- Epigenetics and DNA Methylation
- Esophageal Cancer Research and Treatment
- Lung Cancer Research Studies
- Mycobacterium research and diagnosis
- Chemistry and Stereochemistry Studies
- Autophagy in Disease and Therapy
- Lung Cancer Diagnosis and Treatment
- Bipolar Disorder and Treatment
- Ferroptosis and cancer prognosis
- Peptidase Inhibition and Analysis
- Gastrointestinal disorders and treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Liver Disease and Transplantation
- Circular RNAs in diseases
- Gastroesophageal reflux and treatments
- Hormonal Regulation and Hypertension
- Prostate Cancer Treatment and Research
- Fibroblast Growth Factor Research
Central South University
2011-2025
Soochow University
2014-2025
Third Xiangya Hospital
2008-2025
Nanjing Medical University
2025
Second People’s Hospital of Huai’an
2025
Second Affiliated Hospital of Soochow University
2014-2025
The First Affiliated Hospital, Sun Yat-sen University
2015-2025
Huaian First People’s Hospital
2025
Sun Yat-sen University
2015-2025
Xuzhou Medical College
2025
Background Accumulating epidemiological evidence shows that life event stressors are major vulnerability factors for psychiatric diseases such as depression. It is also well known social isolation in male mice results aggressive behavior. However, it not how isolation-induced aggression affects anxiety and depressive-like behavior isolated subjected to unpredictable chronic mild stress (CMS), an animal model of Methodology/Principal Findings C57/B6 were divided into 3 groups; non-stressed...
Our previous microarray data showed that microRNA-224 (miR-224) was downregulated in human prostate cancer (PCa) tissues compared with adjacent benign tissues. However, the underlying mechanisms by which miR-224 is involved PCa remain unclear. In this study, we identified TRIB1 as a target gene of miR-224. Forced expression suppressed cell proliferation, invasion and migration, promoted apoptosis downregulating TRIB1. Moreover, level negatively correlated downregulation frequently found...
Background/Aims: Golgi phosphoprotein 3 (GOLPH3) is a newly reported oncogene that plays significant role in regulating cell growth. Recent research has shown overexpression of GOLPH3 correlated with patient survival and M classification breast cancer other cancers. However, the mechanisms by which contributes to metastasis non-small lung (NSCLC) have not been previously clarified are therefore focus this work. Methods: Immunohistochemistry (IHC) western blotting analysis were performed...
Astrocyte elevated gene-1 (AEG-1), known as an oncogene, is overexpressed in various cancers and implicated tumor progression metastasis. However, its functional significance underlying molecular mechanisms thyroid cancer remain to be elucidated. In the present study, we detected potential function of AEG-1 papillary (PTC). We also investigated relation between matrix metalloproteases (MMP)2 9 through immunohistochemistry, western blotting, real-time PCR, immunofluorescence staining,...
Dysregulation of hedgehog pathway is observed in numerous cancers. Relevance genes cancer cohort and inhibition its downstream effector (GLI1) towards metastasis cell lines are explored the study.One hundred fifty fresh tumours breast patients were collected for study. Based on differential expression, panel 6 key regulators (SHH, DHH, IHH, PTCH1, SMO GLI1) microarray datasets identified. Expressional profiles aforementioned later correlated with clinico-pathological parameters Pakistani at...
Helicobacter pylori (H. pylori) recurrence remains a significant public health concern. The study aimed to assess H. reinfection rate and identify its risk factors in China. This prospective open cohort, observational was performed at 18 hospitals across 15 provinces Consecutive patients who received the successful initial eradication during 1 January 2012 31 December 2018 were eligible for enrolment. defined as that occurred more than 12-month interval after eradication. Surveyed might be...
Our recent retrospective analysis of the clinical records patients who had breast thermography demonstrated that an abnormal thermogram was associated with increased risk cancer and a poorer prognosis for patient. This study included 100 normal patients, living 126 deceased patients. Abnormal thermograms asymmetric focal hot spots, areolar periareolar heat, diffuse global vessel discrepancy, or thermographic edge sign. Incidence were directly related to results: only 28% noncancer...
Poor habits can worsen gastroesophageal reflux disease (GERD) and reduce treatment efficacy. Few large-scale studies have examined lifestyle influences, particularly eating habits, on GERD in China, research related to quickly, hyperphagia, hot foods is quite limited. The aim of this study was evaluate the relationship between pathogenesis factors produce useful information for development a clinical reference guide through national multicenter survey China.Symptom lifestyle/habit...
PANoptosis is one of several modes programmed cell death (PCD) and plays an important role in many inflammatory immune diseases. The bowel disease (IBD) currently unknown. Differentially expressed PANoptosis-related genes (DE-PRGs) were identified, pathway enrichment analyses performed. LASSO regression model construction, a nomogram model, calibration curves, ROC DCA curves used to evaluate the predictive value model. Predicts transcription factors (TFs) small-molecule drugs DE-PRGs...
Early-stage non-small cell lung cancer (NSCLC) requires accurate preoperative function assessment, but traditional tests have limitations in evaluating regional function. This study aimed to evaluate the efficacy of dual-phase computed tomography (CT) imaging for assessment patients with early-stage NSCLC. Sixty (28 men and 32 women; mean age 55.47±10.30 years) NSCLC were prospectively included this study. The data utilized retrospectively analyzed from collected clinical data. Each patient...
Bone metastasis is the major cause of morbidity and mortality prostate cancer (PCa).Fibroblast growth factor 9 (FGF9) has been reported to promote PCa bone metastasis.However, mechanism by which overexpression FGF9 promotes progression still unknown.Herein, we report that transgenic mice forced express in epithelial cells (F9TG) developed high grade prostatic intraepithelial neoplasia (PIN) an expression leveland time-dependent manner.Moreover, FGF9/TRAMP bigenic (F9TRAMP) grew advanced...
Context: To date, all the familial hyperaldosteronism type III (FH-III) patients reported presenting with typical primary aldosteronism (PA), without showing other adrenal hormone abnormalities. Objective: This study characterized a novel phenotype of FH-III and explored possible pathogenesis. Patients Methods: A male patient presented severe hypertension hypokalemia at age 2 years developed Cushing’s syndrome 20 years. He was diagnosed PA on basis biochemical findings. had massive bilateral...
Objectives Matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) has emerged as a potent tool for detecting drug resistance in tuberculosis (TB); however, concerns about its reliability have been raised. In this study, we assessed the MassARRAY (Sequenom, Inc.), which is MALDI-TOF MS-based method, by comparing it to well-established GeneXpert assay (Cepheid) reference method. Methods A retrospective study was conducted using laboratory data retrieved...
Biliary atresia (BA) is a devastating fibroinflammatory biliary disease that the leading indication for pediatric liver transplants worldwide. Although cholangiocytes are primary target cells, pathogenic mechanisms involving remain elusive. Here, we aimed to characterize role of in BA.
Background: Accumulating literature demonstrates that long noncoding RNAs (lncRNAs) are involved in ferroptosis and gastric cancer progression. However, the predictive value of ferroptosis-related lncRNAs for prognosis therapeutic response is yet to be elucidated (GC). Method: The transcriptomic data corresponding clinical information GC patients were obtained from Gene Expression Omnibus (GEO) Cancer Genome Atlas (TCGA) database. association between regulators was analyzed by Spearman...
The sequential use of signaling pathways is essential for the guidance pluripotent progenitors into diverse cell fates. Here, we show that Shp2 exclusively mediates FGF but not PDGF in neural crest to control lacrimal gland development. In addition preventing p53-independent apoptosis and promoting migration Sox10-expressing crests, also required expression homeodomain transcription factor Alx4, which directly controls Fgf10 periocular mesenchyme necessary induction. We Alx4 binds an...