A5085456539- Immune Cell Function and Interaction
- Spectroscopy and Chemometric Analyses
- Spectroscopy Techniques in Biomedical and Chemical Research
- Advanced Chemical Sensor Technologies
- Retinopathy of Prematurity Studies
- Identification and Quantification in Food
- Retinal Imaging and Analysis
- Immune cells in cancer
- Biomedical Text Mining and Ontologies
- Semantic Web and Ontologies
- Electronic Health Records Systems
- Cancer Immunotherapy and Biomarkers
- T-cell and B-cell Immunology
- Natural Language Processing Techniques
- Catalysis for Biomass Conversion
- Neonatal Respiratory Health Research
- Optical Systems and Laser Technology
- Advanced Text Analysis Techniques
- Galectins and Cancer Biology
- Image Processing Techniques and Applications
- Photoacoustic and Ultrasonic Imaging
- Scientific Computing and Data Management
- Neonatal and fetal brain pathology
- Industrial Vision Systems and Defect Detection
- Sparse and Compressive Sensing Techniques
Zhejiang Gongshang University
2016-2025
Sichuan University
2023-2024
Nanjing University of Information Science and Technology
2008-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2009-2023
Jiangnan University
2023
Peking Union Medical College Hospital
2009-2023
Shanghai Institute of Technology
2023
University of Illinois Urbana-Champaign
2019-2023
ZheJiang Institute For Food and Drug Control
2023
Jinzhou Medical University
2023
A recent development for the efficient and environmentally friendly synthesis of aliphatic amines is transition-metal-catalyzed redox-neutral coupling an alcohol amine, generally referred to as a "borrowing hydrogen" reaction. In this work, we describe first kilogram-scale application technology in PF-03463275, GlyT1 inhibitor developed treatment schizophrenia. Using (Cp*IrCl2)2 reaction has been optimized achieve catalyst loadings lower than 0.05 mol % iridium (S/C ≥ 2000) while retaining...
Retinopathy of prematurity (ROP) is one the main causes childhood blindness. However, insufficient ophthalmologists are qualified for ROP screening. The objective this paper to evaluate performance a deep neural network (DNN) automated screening ROP. training and test sets came from 420 365 wide-angle retina images A transfer learning scheme was designed train DNN classifier. First, pre-processing classifier separated unqualified images. Then, pediatric labeled each image as either or...
Yogurt fermentation is a complex process influenced by raw materials and time, which significantly affect product quality. This study employs two-factor experimental design with two milk varieties Raman spectra collected at nine time points to explore dynamics. Our aim identify key chemical components selecting peak features closely associated these factors. We introduce multi-task least absolute shrinkage selection operator (LASSO) algorithm for simultaneous feature across multiple...
Consciousness is liable to not be defined in scientific research, because it an object of study philosophy too, which actually hinders the integration research on a large scale. The present attempts define consciousness with mathematical approaches by including common meaning across multiple disciplines. By extracting essential characteristics consciousness—transitivity—a categorical model established. This used obtain three layers categories: objects, materials as reflex units, and per se...
Purpose: Advances in mass spectrometry have provided new insights into the role of metabolomics etiology several diseases. Studies on retinopathy prematurity (ROP), for example, overlooked metabolic alterations disease development. We employed comprehensive profiling and gold-standard analysis to explore major metabolites pathways, which were significantly affected early stages pathogenesis toward ROP. Methods: This was a multicenter, retrospective, matched-pair, case-control study....
Abstract Adoptive transfer of donor NK cells has the potential mediating graft‐versus‐leukemia (GVL) effect while suppressing acute graft‐versus‐host‐disease (aGVHD) during allogeneic hematopoietic stem cell transplantation (allo‐HSCT). However, these beneficial effects are limited by transient function adoptively transferred cells. Previous studies demonstrate that cytokine‐induced memory‐like preactivated IL‐12, IL‐15, and IL‐18 have enhanced effector functions long life span in vivo....
Context: To date, all the familial hyperaldosteronism type III (FH-III) patients reported presenting with typical primary aldosteronism (PA), without showing other adrenal hormone abnormalities. Objective: This study characterized a novel phenotype of FH-III and explored possible pathogenesis. Patients Methods: A male patient presented severe hypertension hypokalemia at age 2 years developed Cushing’s syndrome 20 years. He was diagnosed PA on basis biochemical findings. had massive bilateral...
Retinopathy of prematurity (ROP) has been one the worldwide causes blindness among children. Grading and treatment guidelines ROP are mainly based on zone, stage, plus disease. For serious ROP, identifying zone is more important than staging. However, I from RetCam fundus images not accurate subjective by ophthalmologists. To address it, we develop a new deep learning framework to automatically identify images. Specifically, train convolutional neural network (DCNN) algorithm The disc...
Interleukin-1α (IL-1α) plays an important role in inflammation and hematopoiesis. Many tumors have increased IL-1α expression. However, the immune regulatory of secreted tumor development whether it can be targeted for cancer therapy are still unclear. Here, we found that tumoral-secreted significantly promoted hepatocellular carcinoma (HCC) vivo. Tumoral-released were to inhibit T NK cell activation, killing capacity CD8+ cells. Moreover, MDSCs dramatically by tumoral-released both spleens...
Hepatocellular carcinoma (HCC) is the fifth most malignant tumor worldwide and known to be resistant conventional chemotherapy. New therapeutic strategies are urgently needed for treating HCC. Lup-20(29)-en-3H-ol (Lupeol), a novel dietary triterpene, found in fruits, vegetables, medicinal plants possesses multiple bio-activities with very low toxicity. In current study, we investigated its growth-inhibitory effects HCC cell lines SMMC7721 HepG2. vitro studies, lupeol treatment alone caused...
Abstract Hepatocellular carcinoma is a worldwide health problem with limited treatment options and poor prognosis. Inflammation associated liver injury hepatocyte regeneration can lead to fibrosis, cirrhosis, eventually, hepatocellular carcinoma. IL1α one of the most important inflammatory cytokines involved in inflammation tumor development. presents as multiple forms vivo, including precursor, propiece, membrane, secreted forms, their functions have been thought be different. The role...
Although the Co–N–C catalyst exhibits good catalytic performance toward hydrogenation of 5-hydroxymethylfurfural (HMF) with formic acid (FA) as H source, its mechansim is still unclear at molecular level, including competitive aldehyde (−CHO) group and hydrogenolysis hydroxymethyl (−CH2OH) group. Here, a single-atom Co-N3/C surface was modeled an armchair model activated carbon support. Over Co-N3/C, mechanism for hydrogenation/hydrogenolysis HMF FA has been theoretically investigated in...
This study established a method for rapid classification of milk products by combining MALDI-TOF MS analysis with machine learning techniques. The 2 different types was used as an example. To select key variables potential markers, integrated strategies based on 6 feature selection techniques combined support vector (SVM) classifier were implemented to screen the informative features and classify samples. models evaluated compared accuracy, Akaike information criterion (AIC), Bayesian (BIC)....
// Yinsheng Zhang 1 , Xiao Yu Dandan Lin Lei Bo Hu Fengzhang Cao Mei 2 Depei Wu Haiyan Liu Institute of Blood and Marrow Transplantation, Jiangsu Hematology, Collaborative Innovation Center The First Affiliated Hospital Soochow University, Suzhou 215006, P. R. China Immunology Programme, Life Sciences Department Microbiology Immunology, National University Singapore, Singapore 117456, Correspondence to: Liu, email: micliuh@nus.edu.sg Keywords: propeice IL-1α, acute lymphocytic leukemia,...
High-dimensional data are pervasive in this bigdata era. To avoid the curse of dimensionality problem, various reduction (DR) algorithms have been proposed. facilitate systematic DR quality comparison and assessment, paper reviews related metrics develops an open-source Python package pyDRMetrics. Supported include reconstruction error, distance matrix, residual variance, ranking co-ranking trustworthiness, continuity, co-k-nearest neighbor size, LCMC (local continuity meta criterion),...