A5101544823- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- Liver Disease Diagnosis and Treatment
- Anesthesia and Neurotoxicity Research
- Intensive Care Unit Cognitive Disorders
- Ferroptosis and cancer prognosis
- Cancer Research and Treatments
- Platelet Disorders and Treatments
- Hepatitis B Virus Studies
- Galectins and Cancer Biology
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Anesthesia and Sedative Agents
- Lipid metabolism and disorders
- Cancer, Stress, Anesthesia, and Immune Response
- Hepatocellular Carcinoma Treatment and Prognosis
- Cardiac, Anesthesia and Surgical Outcomes
- Cervical Cancer and HPV Research
- Fungal Plant Pathogen Control
- Plant-Microbe Interactions and Immunity
- Cytokine Signaling Pathways and Interactions
- Epigenetics and DNA Methylation
- Renal Diseases and Glomerulopathies
- Gastric Cancer Management and Outcomes
- Effects of Radiation Exposure
Soochow University
2010-2025
Eastern Hepatobiliary Surgery Hospital
2021-2024
Second Military Medical University
2021-2024
Shanxi Medical University
2017-2024
Second Hospital of Shanxi Medical University
2022-2024
Weatherford College
2023
First Affiliated Hospital of Soochow University
2022-2023
Tongren Hospital
2019-2022
Shanghai University
2018-2022
Seventh People's Hospital of Shanghai
2018-2022
This study aims to investigate the effect of pretreatment S-ketamine on postoperative depression (POD) for breast cancer patients with mild/moderate depression. The present randomized, double-blinded controlled trial included 303 from June 2017 2018. All were randomly divided into three groups: (1) control group, treated normal saline; (2) racemic ketamine ketamine; (3) S-ketamine. Operation time, blood loss and hospital stay complications recorded. Visual Analog Scale (VAS) score was...
Abstract Hepatitis B–associated hepatocellular carcinoma (HCC) is often accompanied by severe vascular invasion and portal vein tumor thrombus, leading to a poor prognosis. However, the underlying mechanism of this disease remains obscure. In study, we demonstrate that hepatitis B virus (HBV)–encoded gene HBx induces high IL8 production through MEK–ERK signal activation, enhanced endothelial permeability facilitate invasion. metastatic model using tail injection in transgenic mouse with...
Gallbladder carcinoma (GBC) is the most common biliary tract malignancy with lowest survival rate, primarily arising from chronic inflammation. To better characterize progression inflammation to cancer metastasis, we performed single-cell RNA sequencing across samples of 6 cholecystitis, 12 treatment-naive GBCs, and matched metastases. Benign epithelial cells inflamed gallbladders displayed resting, immune-regulating, gastrointestinal metaplastic phenotypes. A small amount PLA2G2A+ copy...
Significance Immune thrombocytopenia (ITP) patients with antiplatelet glycoprotein (GP) Ib-IX autoantibodies appear refractory to conventional treatments; however, the mechanism remains elusive. Here we show that platelets undergo apoptosis in ITP anti-GPIbα autoantibodies. We demonstrate antibody binding activates Akt, which elicits platelet through activation of phosphodiesterase (PDE3A) and PDE3A-mediated PKA inhibition. Phosphatidylserine (PS) exposure results phagocytosis antibody-bound...
This study aimed to investigate the protective effects and underlying mechanisms of cistanche on sevoflurane-induced aged cognitive dysfunction rat model. Aged (24 months) male SD rats were randomly assigned four groups: control group, sevoflurane + group. Subsequently, inflammatory cytokine levels measured by ELISA, was evaluated water maze test, open-field test fear conditioning test. Three days following anaesthesia, killed hippocampus harvested for analysis relative biomolecules. The...
Transketolase (TKT), a key rate-limiting enzyme in the non-oxidative branch of pentose phosphate pathway (PPP), provides more than 85% ribose required for de novo nucleotide biosynthesis and promotes development hepatocellular carcinoma (HCC). Pharmacologic inhibition TKT could impede HCC enhance treatment efficacy. However, no safe effective inhibitor has been approved.An online two-dimensional protein immobilised biochromatographic system was established high-throughput screening ligands....
Background The potency of T cell-mediated responses is a determinant immunotherapy effectiveness in treating malignancies; however, the clinical efficacy T-cell therapies has been limited hepatocellular carcinoma (HCC) owing to extensive immunosuppressive microenvironment. Objective Here, we aimed investigate key genes contributing immune escape HCC and raise new therapeutic strategy for remoulding Design genome-wide vivo clustered regularly interspaced short palindromic repeats (CRISPR)...
Interleukin-1α (IL-1α) plays an important role in inflammation and hematopoiesis. Many tumors have increased IL-1α expression. However, the immune regulatory of secreted tumor development whether it can be targeted for cancer therapy are still unclear. Here, we found that tumoral-secreted significantly promoted hepatocellular carcinoma (HCC) vivo. Tumoral-released were to inhibit T NK cell activation, killing capacity CD8+ cells. Moreover, MDSCs dramatically by tumoral-released both spleens...
ABSTRACT Iloprost, a prostacyclin (PGI 2 ) analogue, stimulates the IP receptor (PTGIR) to interact with Gsα β/γ complex, leading activation of adenylate cyclase, which enzyme produces second messenger cAMP. Elevation in cAMP triggers intracellular signalling events and regulates wide variety cellular activities. Thus, we evaluated effects Iloprost on platelet function apoptosis vivo haemostasis thrombosis, as well underlying mechanisms. Firstly, showed that concentration‐dependently...
Abstract Hepatocellular carcinoma is a worldwide health problem with limited treatment options and poor prognosis. Inflammation associated liver injury hepatocyte regeneration can lead to fibrosis, cirrhosis, eventually, hepatocellular carcinoma. IL1α one of the most important inflammatory cytokines involved in inflammation tumor development. presents as multiple forms vivo, including precursor, propiece, membrane, secreted forms, their functions have been thought be different. The role...
Sevoflurane, a commonly used volatile anesthetic, recently has been found neurotoxicity in the central nervous system of neonatal rodents. This study aimed to reveal whether phosphodiesterase 4 (PDE-4) inhibitor roflumilast protective functions sevoflurane-induced nerve damage.Hippocampal neurons were isolated from juvenile rats, and exposed sevoflurane with or without treatment. Cell viability apoptosis respectively assessed by CCK-8 flow cytometry. Western blot analysis was performed...
<b><i>Introduction:</i></b> The blood urea nitrogen (BUN)-to-creatinine (Cr) ratio (BUN/Cr ratio) may be used to evaluate the need for intervention of acute upper gastrointestinal bleeding (AUGIB). This study aimed explore predictive value BUN/Cr in AUGIB. <b><i>Methods:</i></b> retrospective observational included patients with AUGIB hospital’s emergency department between August 2019 and May 2023. were grouped according whether they underwent...
The associations between human papillomavirus (HPV) infection or hormonal exposure and cervical cancer risk are well established. However, to the best of our knowledge, association high endogenous estradiol levels in conjunction with HPV/HPV16 squamous cell carcinoma remains unknown. To investigate this, current study conducted a matched case-control Shanxi Province, China, which clinical samples were obtained from 74 females newly diagnosed uterine cervix healthy who selected 582 according...
With resistance to current agricultural fungicides rising, a great need has emerged for new antifungals with unexploited targets. In response, we report novel series of diazaborines potent activity against representative fungal plant pathogens. To identify their mode action, selected resistant isolates using the model fungus Saccharomyces cerevisiae. Whole-genome sequencing independent diazaborine-resistant lineages identified recurring mutation in ERG25, which encodes C-4 methyl sterol...
Interleukin-1α is mainly expressed on the cell membrane, but can also be secreted during inflammation. The roles of and membrane IL-1α in acute liver inflammation are still not known. Here, we examined functions a mouse model carbon tetrachloride-induced injury. We show that aggravates damage slightly protects mice from Further studies showed promotes T-cell activation. It increased expansion CD11b(+) Gr1(+) myeloid cells, which may serve as negative regulator Moreover, induced IL-6...
Background Interleukin-15 (IL-15) plays important roles in the immune system and development of hematopoietic cells. Previous studies revealed that five SNPs IL-15, rs10519612, rs10519613, rs35964658, rs17007695 rs17015014, were significantly associated with childhood Acute Lymphoblastic Leukemia (ALL) treatment response. In adult ALL, expression IL-15 was also correlated immunophenotypes ALL. Therefore, we hypothesize might be Methods Findings We genotyped above gene by PCR-RFLP assays ALL...
Fungal pathogens pose an increasing threat to global food security through devastating effects on staple crops and contamination of supplies with carcinogenic toxins. Widespread deployment agricultural fungicides has increased crop yields but is driving increasingly frequent resistance available agents creating environmental reservoirs drug-resistant fungi that can also infect susceptible human populations. To uncover non-cross-resistant modes antifungal action, we leveraged the unique...
An "atypical" physiological function of angiotensin-converting enzyme 2 (ACE2) during COVID-19 is rarely mentioned. In the intestine, where ACE2 highly expressed,1Hamming I. et al.J Pathol. 2004; 203: 631-637Crossref PubMed Scopus (3992) Google Scholar it acts as a regulator homeostasis dietary amino acids, particularly tryptophan (Trp). Trp catabolism through kynurenine (Kyn) pathway plays an important role in regulating balance between effector and regulatory immune responses; increased...
Abstract Postoperative cognitive dysfunction (POCD) is a prevalent disorder after anaesthesia in the elderly patients. Roflumilast (RF), phosphodiesterase 4 (PDE‐4) inhibitor, could improve cognition with no side effects. Here, we sought to explore efficacy of RF improvement caused by sevoflurane (Sev). Sprague–Dawley rats were anaesthetized, and hippocampal neurons treated Sev develop vivo vitro POCD models, followed administration. The mechanism PKA‐CREB MEK/ERK pathways pathogenesis was...
ABSTRACT Branched-chain amino acids (BCAAs, including leucine, isoleucine, and valine) have emerged as major players in metabolic health diseases, but the underlying mechanisms remain obscure. Here, we report that BCAA catabolism drives adipogenesis via an intermediate metabolite of leucine promotes subcutaneous white adipose tissue (sWAT) expansion during obesity. Genetic analyses humans mice reveal catabolic pathway WAT is strongly correlated with physiology obesity traits. Altering mature...