A5068220110- Anesthesia and Neurotoxicity Research
- Innovative Microfluidic and Catalytic Techniques Innovation
- Intensive Care Unit Cognitive Disorders
- Microfluidic and Capillary Electrophoresis Applications
- 3D Printing in Biomedical Research
- Phosphodiesterase function and regulation
Shanghai University of Traditional Chinese Medicine
2022-2023
Longhua Hospital Shanghai University of Traditional Chinese Medicine
2022-2023
Abstract Postoperative cognitive dysfunction (POCD) is a prevalent disorder after anaesthesia in the elderly patients. Roflumilast (RF), phosphodiesterase 4 (PDE‐4) inhibitor, could improve cognition with no side effects. Here, we sought to explore efficacy of RF improvement caused by sevoflurane (Sev). Sprague–Dawley rats were anaesthetized, and hippocampal neurons treated Sev develop vivo vitro POCD models, followed administration. The mechanism PKA‐CREB MEK/ERK pathways pathogenesis was...
Obesity is one of the foremost public health concerns. Human pancreatic lipase (hPL), a crucial digestive enzyme responsible for digestion dietary lipids in humans, has been validated as an important therapeutic target preventing and treating obesity. The serial dilution technique commonly used to generate solutions with different concentrations can be easily modified drug screening. Conventional gradient often performed tedious multiple manual pipetting steps, where it difficult precisely...