A5100605418- Animal Virus Infections Studies
- Microbial infections and disease research
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Aquaculture disease management and microbiota
- Virus-based gene therapy research
- Viral gastroenteritis research and epidemiology
- Cancer Research and Treatments
- Bacteriophages and microbial interactions
- Animal Disease Management and Epidemiology
- Circular RNAs in diseases
- Liver Disease Diagnosis and Treatment
- Brucella: diagnosis, epidemiology, treatment
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Genomics and Phylogenetic Studies
- RNA regulation and disease
- Galectins and Cancer Biology
- Ferroptosis and cancer prognosis
- Hepatitis B Virus Studies
- Insect and Pesticide Research
- Influenza Virus Research Studies
- Plant responses to water stress
- ECG Monitoring and Analysis
- Microbial Community Ecology and Physiology
Hainan University
2018-2024
Northeast Normal University
2023-2024
Yunnan Animal Science and Veterinary Institute
2022-2024
Nanjing Medical University
2020-2024
First Affiliated Hospital of Wannan Medical College
2019-2024
Chinese Academy of Agricultural Sciences
2023-2024
Institute of Agricultural Economics and Development
2023-2024
Jiangsu Province Hospital
2024
First People's Hospital of Nanning
2024
Taizhou Central Hospital
2022-2023
Abstract Glucose transporter GLUT1 is a transmembrane protein responsible for the uptake of glucose into cells many tissues through facilitative diffusion. Plasma membrane (PM) localization essential by GLUT1. However, mechanism underlying PM remains enigmatic. We find that palmitoylated at Cys207, and S-palmitoylation required maintaining localization. Furthermore, we identify DHHC9 as palmitoyl transferase this critical posttranslational modification. Knockout or mutation Cys207 to serine...
Abstract Hepatitis B–associated hepatocellular carcinoma (HCC) is often accompanied by severe vascular invasion and portal vein tumor thrombus, leading to a poor prognosis. However, the underlying mechanism of this disease remains obscure. In study, we demonstrate that hepatitis B virus (HBV)–encoded gene HBx induces high IL8 production through MEK–ERK signal activation, enhanced endothelial permeability facilitate invasion. metastatic model using tail injection in transgenic mouse with...
Despite therapeutic advancements, there has been little improvement in the survival status of patients with oral squamous cell carcinoma (OSCC). HOX antisense intergenic RNA (HOTAIR) shown to be dysregulated several cancer types. However, roles HOTAIR OSCC remain largely unknown. In this study, we investigated association expression clinicopathological features and crucial modulation tumor progression. Our results showed that was highly expressed both tissue samples lines compared...
Abstract This study investigated the cancer‐promoting effect of ferroptosis regulator DNA damage‐inducible transcript 4 (DDIT4) and its relevant mechanisms. Vital ferroptosis‐related genes were identified using bioinformatic methods on basis data collected from TCGA seven other online databases. Cell Counting Kit‐8 (CCK8), colony formation, wound‐healing transwell assays, western blot analysis conducted for verifying biological role DDIT4 in vitro. The immune score tumor purity calculated R...
Aberrant N7 -methylguanosine (m7G) levels closely correlate with tumor genesis and progression. NCBP2 EIF4E3 are two important m7G-related cap-binding genes. This study aimed to identify the relationship between EIF4E3/NCBP2 function immunological characteristics of head neck squamous cell carcinoma (HNSCC). Hierarchical clustering was employed in classifying HNSCC patients into groups based on expressions EIF4E3. The differentially expressed genes were identified groups, GO functional...
The prevalence of diabetic kidney disease (DKD) is increasing annually. Damage to and loss podocytes occur early in DKD. tRNA-derived fragments (tRFs), originating from tRNA precursors or mature tRNAs, are associated with various illnesses. In this study, tRFs were identified, their roles podocyte injury induced by high-glucose (HG) treatment explored. High-throughput sequencing treated HG was performed identify differentially expressed tRFs. Gene Ontology (GO) Kyoto Encyclopedia Genes...
Background and Purpose The poor prognosis of acute megakaryoblastic leukaemia (AMKL) means there is a need to develop novel therapeutic methods treat this condition. It was recently shown that inducing megakaryoblasts undergo terminal differentiation effective as treatment for AMKL. This encouraged us identify compound induces megakaryocyte differentiation, which could then act potent anti‐leukaemia agent. Experimental Approach effects tetrandrine on the expression CD41 cell morphology were...
Goats have become one of the most adaptive and important livestock species distributed in developing countries recent years. The Hainan Black goat is a native breed region that generally well-liked by local population thus raised large numbers. However, genomic diversity selective signals not been clearly elucidated yet. Therefore, this study, we performed whole-genome resequencing 16 goats compared results with those 71 6 other breeds from different geographic regions. Principal component...
(1) Background: Mannheimia haemolytica (M. haemolytica) is an opportunistic pathogen and mainly associated with respiratory diseases in cattle, sheep, goats. (2) Methods: In this study, a mouse infection model was established using M. strain isolated from Histopathological observations were conducted on various organs of the mice, bacterial load determination RNA-seq analysis specifically performed spleens mice. (3) Results: The findings study suggest that chemokines, potentially present...
Recombinant oncolytic adenovirus offers a novel and promising cancer treatment approach, but its standalone efficacy remains limited. This study investigates combination strategy by co-administering recombinant Adv-loaded silk hydrogel with PD-L1 inhibitor for patients bladder to enhance outcomes. Bladder tissues from mice were collected subjected single-cell sequencing, identifying CRB3 as key gene in malignant cells. Differential expression functional enrichment analyses performed,...
Abstract This article adopts an interdisciplinary lens integrating psychology and existentialism to examine how digital resurrection technology, epitomized by deathbots, reshapes human perceptions of death elevates interaction between us deathbots into existential practice. By interrogating the interplay technologies death, techno-psychological foundations their therapeutic efficacy in psychological philosophical frameworks, attendant quandaries, we demonstrate that: (1) The perceived...
Orf, caused by Orf virus (ORFV), is a globally distributed zoonotic disease responsible for serious economic losses in the agricultural sector. However, mechanism underlying ORFV infection remains largely unknown. Circular RNAs (circRNAs), novel type of endogenous non-coding RNAs, play important roles various pathological processes but their involvement and host response unclear. In current study, whole transcriptome sequencing small RNA were performed ORFV-infected goat skin fibroblast...
Abstract Background The roles of lncRNA PLAC2 in bladder cancer (BC) were explored. Methods expression two types tissue BC patients was detected by RT-qPCR and the data compared paired t test. 56 staged according to AJCC criteria, 12, 15, 15 14 cases classified into stage I-IV, respectively. TGF-β1 miR-663 tissues also experiments. Results Our showed that levels significantly lower than non-cancer tissues. not affect clinical stages low predicted survival rate. positively correlated with...
Orf is a zoonotic disease that has caused huge economic losses globally. Systematical analysis of dysregulated cellular micro RNAs (miRNAs) in response to virus (ORFV) infection not been reported. In the current study, miRNA sequencing and RNA (RNA-seq) were performed goat skin fibroblast (GSF) cells at 0, 18, 30 h post (h.p.i). We identified 140 221 differentially expressed (DE) miRNAs 18 h.p.i, respectively. also 729 3961 DE genes (DEGs) GO enrichment indicates apoptotic regulation,...
Brucella-caused brucellosis is one of the most widespread worldwide zoonoses. Lipopolysaccharide (LPS) Brucella, which functions as pathogen-associated molecular patterns (PAMPs), an important virulence factor that elicits protective antibodies. Per B. melitensis involved in biosynthesis O-side chain LPS. Autophagy a crucial element innate immune response against intracellular pathogens including Brucella. In this study, we observed autophagy was inhibited RAW264.7 cells infected with...
Background Olfactory ensheathing cell (OEC) transplantation is a promising or potential therapy for spinal cord injury (SCI). However, the effects of injecting OECs directly into SCI site have been limited and unsatisfied due to complexity SCI. To improve outcome, proper biomaterials are thought be helpful since these materials would allow cells grow three-dimensionally guide migration. Methods In this study, we made new peptide hydrogel scaffold named GRGDSPmx by mixing pure RADA16 designer...
Pasteurella multocida can cause goat hemorrhagic sepsis and endemic pneumonia. Respiratory epithelial cells are the first line of defense in lungs during P. infection. These act as a mechanical barrier activate immune response to protect against invading pathogenic microorganisms. Upon infection, adheres causes changes cell morphology transcriptome. ATAC-seq was conducted determine chromatin open region multocida-infected bronchial based on transcriptional regulation. A total 13,079 28,722...