A5101131884- Birth, Development, and Health
- Reconstructive Facial Surgery Techniques
- Facial Nerve Paralysis Treatment and Research
- Reconstructive Surgery and Microvascular Techniques
- Gestational Diabetes Research and Management
- Pregnancy and preeclampsia studies
- Adipose Tissue and Metabolism
- Facial Rejuvenation and Surgery Techniques
- Pancreatic function and diabetes
- Vascular Procedures and Complications
- Congenital heart defects research
- Prenatal Substance Exposure Effects
- Urologic and reproductive health conditions
- Genetics, Aging, and Longevity in Model Organisms
- Congenital Heart Disease Studies
- Tissue Engineering and Regenerative Medicine
- Metabolism, Diabetes, and Cancer
- Anorectal Disease Treatments and Outcomes
- Sexual Differentiation and Disorders
- Periodontal Regeneration and Treatments
- Retinopathy of Prematurity Studies
- Wound Healing and Treatments
- Microbial infections and disease research
- Epigenetics and DNA Methylation
- Neonatal Health and Biochemistry
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2024
Peking Union Medical College Hospital
2022-2024
Shanghai First Maternity and Infant Hospital
2023-2024
Obstetrics and Gynecology Hospital of Fudan University
2024
International Peace Maternity & Child Health Hospital
2021-2023
Shanghai Jiao Tong University
2021-2023
Southern Medical University
2022
Shenzhen Maternity and Child Healthcare Hospital
2022
Weatherford College
2022
Follicle-stimulating hormone (FSH) is involved in mammalian reproduction via binding to FSH receptor (FSHR). However, several studies have found that and FSHR play important roles extragonadal tissue. Here, we identified the expression of human mouse pancreatic islet β-cells. Blocking signaling by Fshr knock-out led impaired glucose tolerance owing decreased insulin secretion, while high levels caused insufficient secretion as well. In vitro, orchestrated glucose-stimulated (GSIS) a bell...
Gestational diabetes mellitus (GDM) with intrauterine hyperglycemia induces a series of changes in the placenta, which have adverse effects on both mother and fetus. The aim this study was to investigate placenta GDM its gender differences. In study, we established an model using ICR mice. We collected placental specimens from mice before birth for histological observation, along tandem mass tag (TMT)-labeled proteomic analysis, stratified by sex. When analysis not segregated sex, group...
Purpose: Advances in mass spectrometry have provided new insights into the role of metabolomics etiology several diseases. Studies on retinopathy prematurity (ROP), for example, overlooked metabolic alterations disease development. We employed comprehensive profiling and gold-standard analysis to explore major metabolites pathways, which were significantly affected early stages pathogenesis toward ROP. Methods: This was a multicenter, retrospective, matched-pair, case-control study....
Abstract Studies on humans and animals suggest associations between gestational diabetes mellitus (GDM) with increased susceptibility to develop neurological disorders in offspring. However, the molecular mechanisms underpinning intergenerational effects remain unclear. Using a mouse model of during pregnancy, we found that intrauterine hyperglycemia exposure resulted memory impairment both first filial (F1) males second (F2) from F1 male Transcriptome profiling F2 hippocampi revealed...
Extensive facial burn scars are a tragedy for patients and often pose great challenge to surgeons because of the high esthetic functional demands. For with healthy skin in neck region, cervical flap is highly recommended resurfacing; however, on midline needs more expansion than that either side, especially treatment large defects. The sufficient longitudinal soft tissue anterior ensures normal shape as well range extension, rotation, lateral flexion. To overcome this, we developed an...
Growing evidence suggests that adverse intrauterine environments could affect the long-term health of offspring. Recent indicates gestational diabetes mellitus (GDM) is associated with neurocognitive changes in However, mechanism remains unclear. Using a GDM mouse model, we collected hippocampi, structure critical to cognitive processes, for electron microscopy, methylome and transcriptome analyses. Reduced representation bisulfite sequencing (RRBS) RNA-seq fetal hippocampi showed altered...
Mounting evidence has shown that intrauterine hyperglycemia exposure during critical stages of development may be contributing to the increasing prevalence diabetes. However, little is known about mechanisms responsible for offspring metabolic disorder. In this present study, we explored on fetal pancreatic metabolome, and its potential link impaired glucose tolerance in adult offspring. Here, using a GDM mouse model, found metabolome profiling pancreas from male female fetus showing altered...
Abstract Over the past 20 years, we have designed various types of expanded cervical flaps for large facial defects and achieved excellent tissue matching. This study was performed to propose a treatment strategy flap selection reconstruction different units. The authors retrospectively reviewed application rehabilitation in our department between January 2003 2023. included 122 patients with unilateral (62.3%) bilateral (37.7%) deformities ranging from zygomatic arch chin. median area...
Aphallia is an extremely rare congenital malformation of unknown cause, with few reports in the literature. It usually associated other urogenital and gastrointestinal anomalies believed to be a result either absence genital tubercle or chromosome polymorphism. Herein, we describe case aphallia urethrorectal fistula our treatment for this patient.An 8-year-old boy was brought hospital by his parents because penis. The child male per karyotype had excess heterochromatin on 9 (46 XY qh+). No...
The aim of this study was to present the 15-year clinical results using a preexpanded pedicle medial arm flap for repairing massive facial and cervical defects.
Advanced hidradenitis suppurativa (HS) is often irresponsive to conservative treatment and requires extensive surgery improve the clinical symptoms prevent recurrence. This study aimed assess effectiveness of single‐stage split‐thickness skin grafting in patients with Hurley Stage III HS. A retrospective review all cases HS received was done. Data on patient demographics, lesion characters, surgical details, follow‐up information were collected. Fifty‐two located axillary, groin, perineum,...
Traumatic injury or tumor resection can lead to eyelid defects, nasal and cheek defects. The temporal flap pedicled with orbicularis oculi muscle (OOM) be used repair these This cadaver-based anatomic study aimed evaluate the blood supply of this investigate its clinical implications.Twenty hemifaces from 10 cadavers were in study. number arteries supplying OOM flap, diameter artery entering OOM, maximum width recorded. All data presented as mean±SD values analyzed using Student t -test. A P...
We aimed to present our 20-year experience of using the deep inferior epigastric vessels as recipient for free scapular flaps phalloplasty and evaluate outcomes. Penile reconstruction was performed a flap between 2000 2020 by same surgical team. Deep were used in all cases. The techniques outcomes described. Overall, 73 patients artery (DIEA) artery. Regarding veins, 2 veins anastomosed 72 (98.6%) patients, 1 vein (DIEV) patient, DIEV 14, + superficial (SIEV) 13, circumflex iliac (SCIV) 38,...
To present our experience with pre-expanded medial upper arm flap in facial and neck reconstruction.This was a retrospective study operated between January 1st, 2001 2021, at the Plastic Surgery Hospital, Chinese Academy of Medical Sciences, Peking Union College. Staged face and/or reconstruction performed.Forty-one patients were treated institution thirty-eight (forty-three flaps) included this cohort as. They ranged from 6 to 44 years old. There no total loss cohort. Partial necrosis...
Reconstruction of facial soft-tissue defects may pose a dilemma for plastic surgeons, as the flaps must be reliable to obtain natural appearance while minimizing donor site morbidities. This clinical study describes reconstructive method infraorbital and zygomatic using pre-expanded rotation flap based on orbicularis oculi muscle (OOM).The surgeries were subdivided into 2 stages. In first stage operation, 100 200 mL expander was placed underneath temporal area through hairline incision....