A5015668482- Cancer-related Molecular Pathways
- Axon Guidance and Neuronal Signaling
- Kruppel-like factors research
- Fibroblast Growth Factor Research
- Epigenetics and DNA Methylation
- Biosensors and Analytical Detection
- Hedgehog Signaling Pathway Studies
- Cancer, Hypoxia, and Metabolism
- Genomics and Chromatin Dynamics
- Advanced biosensing and bioanalysis techniques
- SARS-CoV-2 detection and testing
- Paraoxonase enzyme and polymorphisms
- Pomegranate: compositions and health benefits
- Cancer Genomics and Diagnostics
- MicroRNA in disease regulation
- Cancer-related gene regulation
- Circadian rhythm and melatonin
- Genomic variations and chromosomal abnormalities
- Circular RNAs in diseases
- Airway Management and Intubation Techniques
- Wnt/β-catenin signaling in development and cancer
- Cancer Mechanisms and Therapy
- HER2/EGFR in Cancer Research
- Berberine and alkaloids research
- Peptidase Inhibition and Analysis
Airedale General Hospital
2021-2024
Kunming University of Science and Technology
2024
COMSATS University Islamabad
2015-2024
Capital University of Science and Technology
2024
University of Gujrat
2024
Our Lady of Lourdes Medical Center
2020
Our Lady of Lourdes Hospital
2020
Cardiff University
2014-2017
Tenovus Cancer Care
2014
Dysregulation of hedgehog pathway is observed in numerous cancers. Relevance genes cancer cohort and inhibition its downstream effector (GLI1) towards metastasis cell lines are explored the study.One hundred fifty fresh tumours breast patients were collected for study. Based on differential expression, panel 6 key regulators (SHH, DHH, IHH, PTCH1, SMO GLI1) microarray datasets identified. Expressional profiles aforementioned later correlated with clinico-pathological parameters Pakistani at...
Abstract Sonic Hedgehog signaling is critical for breast morphogenesis and cancer. The present study was conducted to explore the influence of SHH/GLI1 axis on epithelial mesenchymal transition invasion in cancer cells. positive samples demonstrated high expression Snail Vimentin with relatively low E-cadherin. Overexpression patients also associated poor overall survival. Interestingly, GANT61 (GLI1 inhibitor) exposure significantly reduced cell viability induced apoptosis at 10 µM....
Abstract Global impact of COVID-19 pandemic has heightened the urgency for efficient virus detection and identification variants such as Q57H mutation. Early SARS-CoV-2 among densely populated developing countries is paramount objective. Although RT-PCR assays offer accuracy, however, dependence on expansive kits availability allied health resources pose an immense challenge countries. In current study, RT-LAMP based SARS-Cov-2 with subsequent confirmation variant through ARMS-PCR was...
Corporate gender quotas have been widely introduced across Western countries to address women’s underrepresentation in economic leadership roles. The adoption of quota policies rests upon the belief that these are desirable since goal is instill equality society. current research investigated UK participants’ evaluations three hiring policies: merit-based candidate selection, shortlist quota, and outcome on perceived fairness efficiency selecting most qualified candidate. In Experiment 1, we...
The MammaPrint™ gene signature, currently used in clinical practice, provides prognostic information regarding the recurrence and potential metastasis breast cancer patients. However, of 70 genes included can only be estimated at RNA expression level. In this study, we investigated whether copy number DNA level as a tool for cancer, variations (CNVs) are major contributors to progression. We performed CNV profiling 59 cell lines 650 patients, using publicly available data Cancer Genome Atlas...
The sudden outbreak of the novel Coronavirus infectious disease (COVID-19) resulted in significant challenges to global health systems. One primary is rapid, reliable, and accurate detection severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) virus among suspected COVID-19-infected individuals. At present, quantitative real-time PCR (qRT-PCR) a widely used diagnostic method. However, it requires expensive instruments expertise interpretation results. These constraints reflect need...
Abstract The pandemic SARS-CoV-2 (Severe acute respiratory syndrome coronavirus 2) has created a widespread panic across the globe especially in developing countries like Pakistan. lack of resources and technical staff are causing havoc challenges detection prevention this global outbreak. Therefore, less expensive massive screening suspected individuals for COVID-19 is required. In study, user-friendly technique reverse transcription-loop mediated isothermal amplification (RT-LAMP) was...
Both forms of diabetes mellitus have several detrimental effects on the male reproductive system, including damage to testicles and impaired spermatogenesis. This study aimed compare probable protective effect ellagic acid nanoformulation (NEL), regular (EL), metformin (MET), their combination testicular induced by in rats. Diabetes was 6 groups (n = 6) BALB/c rats high-fat diet (HF) plus streptozotocin (STZ). The were treated with EL, NEL, MET, EL NEL MET. A healthy set served as a control...
Background Fibroblast (FGFs) and insulin (IGF) growth factor pathways are among 10 most recurrently altered genomic in pancreatic ductal adenocarcinoma (PDAC). However, the prognostic therapeutic relevance of FGF IGF PDAC is largely unknown. Methods We investigated relationship between fibroblast pathway gene expression clinicopathological features three independent transcriptomic cohorts 532 patients. Furthermore, we have examined coexpressed genes specific to marker identified from these...
Colorectal cancer (CRC) is a heterogeneous disease and activation of WNT TGFβ mediated oncogenic pathways frequently observed in this pathology. However, to date, limited reports have been published addressing the association circadian clock with CRC pathogenesis stratification. The current study aims at assessing expression important markers, PER2, PER3 NR1D1, independent cohorts their associations CRC-related pathways.Gene analysis was performed using available GEO (GSE39582) TCGA...
The underlying mechanism of fibroblast growth factor receptor 1 (FGFR1) mediated carcinogenesis is still not fully understood. For instance, FGFR1 upregulation leads to endocrine therapy resistance in breast cancer patients. current study aimed identify FGFR1-linked genes devise improved therapeutic strategies. RNA-seq and microarray expression data 1,425 patients from two independent cohorts were downloaded for the analysis. Gene Set Enrichment Analysis (GSEA) was performed differentially...
In this study, the role of claudins in cancer progression was explored among breast cancer-affected women.Two cohorts (discovery and validated) women were used. discovery cohort, 90 freshly excised tumor tissues along with adjacent free specimens collected at time surgery. These processed for RNA isolation complementary DNA synthesis. After designing primers claudin 3, 4, 7, these sequences synthesized from Macrogen, Korea. Claudin expression respective tumors controls assessed using...
This study examines when and why female employees may opt for entrepreneurship at some stage of their professional careers. Using the theoretical framework social cognitive career theory, this investigates impact employee work volition on entrepreneurial choice intentions, mediating role psychological empowerment, moderating effect glass ceiling syndrome acting as a proximal environmental influencer (support or barrier). is quantitative that collects data using survey questionnaires from 450...